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82 results for “atherosclerosis”
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Review ArticleOpen accessIn the keywordsCoenzyme Q10 Supplementation Effect on Systemic DiseasesAya Jabbar HusseinThis review paper aims to examine recent RandomizedClinical Trials (RCTs) and review articles evaluating the role of CoQ10 in themanagement of atherosclerosis, and coronary heart disease, with particularfocus on Statin-Associated Muscle Symptoms (SAMS), chronic heart failure, andthe effect on cardiovascular risk factors. With an evaluation of its impacts onpatients' well‐being, it seeks to outline the existing opportunities for usingCoQ10 in … …American Journal of Pharmacology and Toxicology, Vol. 17, Issue 1 · 20 Oct 2022 · 6,530 accessesView PDFCite
Research ArticleOpen accessIn the keywordsReduced Levels of Testosterone Induce LDL Oxidation and Atherosclerotic Lesions Involving Inflammatory Imbalance and Reduced Macrophage ApoptosisPlacielle Fiorezi Filete, Flávia de Souza Andrade Moraes, Girlandia Alexandre Brasil et al.Atherosclerosis is among the major cardiovascular diseases that cause death in the world. Men who are deficient in androgen hormones are more susceptible to this disease. The aim of this study was to evaluate the influence of reduced levels of testosterone on the lipid profile, pro and anti-inflammatory cytokines, apoptosis of peritoneal macrophages and the development of atherosclerosis in LDLr-/-mice, … …OnLine Journal of Biological Sciences, Vol. 19, Issue 4 · 6 Dec 2019 · 7,342 accessesView PDFCite
Research ArticleOpen accessIn the keywordsEffect of Garcinia Atroviridis on Oxidative Stress and Atherosclerotic Changes in Experimental Guinea PigsAdel. A. Amran, Zaiton Zakaria, Faizah Othman, Paden MoratProblem statement: Oxidative stress plays a major role in hypercholesterolemia induced atherosclerosis. Garcinia atroviridis has been shown to exhibit antioxidant properties. Approach: The present study aimed to investigate the effect of Garcinia atroviridis on the oxidative stress in guinea pigs fed with high cholesterol diet. Twenty-four male Guinea pigs were divided into four groups. Group I served as control while … …American Journal of Pharmacology and Toxicology, Vol. 5, Issue 2 · 30 Jun 2010 · 9,038 accessesView PDFCite
Research ArticleOpen accessIn the keywordsInhibition of Cholesterol Esterification Influences Cytokine Exspression in Lypopolisaccharide-activated P388D1 MacrophagesRosa Rita Bonatesta, Francesca Sanna, Sabrina Uda et al.Several in vivo and in vitro studies have demonstrated the involvement of infectious agents in the development of atherosclerosis. However, the mechanisms by which micro-organisms induce and/or aggravate atherosclerosis, are so far unclear. Accumulation of cholesterol esters and lipid laden cell formation are hallmark of the atherogenesis, however, the possible relationship between cholesterol esterification and the signal-transducing component of LPS … …American Journal of Infectious Diseases, Vol. 3, Issue 3 · 30 Sep 2007 · 7,484 accessesView PDFCite
Research ArticleOpen accessIn the keywordsAlterations of HDL Subclasses in Different Lipid Levels of Men and WomenYuye Yang, Luchuan Yang, Mingde Fu et al.With the increase of plasma TG level, both in men and women, apoA-I concentrations of preβ1-HDL and HDL3a were significantly higher while HDL2a and HDL2b were significantly lower. Similarly, with the increase of plasma LDL-C level, apoA-Iconcentrations of preβ1-HDL, HDL3c(in men) and HDL3b were significantly higher while apoA-Iconcentrations of HDL2b were significantly lower. And with the decrease of plasma HDL-C, … …American Journal of Immunology, Vol. 1, Issue 2 · 30 Jun 2005 · 9,077 accessesView PDFCite
Research ArticleOpen accessIn the keywordsDietary supplementation with Cyperus esculentus L (tiger nut) tubers attenuated atherosclerotic lesion in apolipoprotein E knockout mouse associated with inhibition of inflammatory cell responsesMohamed L. Salem, Mohsen Zommara, K. ImaizumiAtherosclerosis is a pathological process, where recruitment of mononuclear cells results in the growth of fibro-fatty plaques. Apolipoprotein E (ApoE) is a legend for the uptake of lipoproteins, and deficiency of ApoE leads to the accumulation of low-density lipoprotein. Utilizing ApoE-/- mouse, which spontaneously develop atherosclerosis on low-fat chow diets, the present study showed that feeding these mice on a … …American Journal of Immunology, Vol. 1, Issue 1 · 31 Mar 2005 · 10,479 accessesView PDFCite
Research ArticleOpen accessIn the keywordsMMP-9 is a Potential Prognostic Marker of Left Ventricular Remodeling in Patients with Coronary Artery DiseaseMikhail Aleksandrovich Popov, Anastasia Vladimirovna Poznyak, Dmitry Valerievich Shumakov et al.Matrix Metalloproteinase-9 (MMP-9) emerges as a promising prognostic marker for assessing left ventricular remodeling in patients with coronary artery disease, particularly in the context of Ischemic Heart Disease (IHD) complicated by left ventricular aneurysm. In this study, we conducted two parallel investigations to explore the prognostic significance of MMP-9 in patients with multivessel coronary artery disease undergoing left ventricular reconstruction … …OnLine Journal of Biological Sciences, Vol. 24, Issue 4 · 11 Jul 2024 · 4,314 accessesView PDFCite
Research ArticleOpen accessIn the keywordsVitamin D Supplements Tone Down the Progression of Atheromatous Plaque Formation in a Dose-Dependent MannerAhmed Farouk, Khalid M. Mohany, Magdy Algowhary et al.Hypovitaminosis D has a negative impact on the cardiovascular system. We performed the current study to investigate the expression of Vitamin D Receptor (VDR) in atherosclerotic human male aortas and to examine the effect of different doses of Vit. D supplementation on VDR expression in the aortas of male rats fed a High-Fat Diet (HFD). Human participants included 50 atherosclerotic … …American Journal of Biochemistry and Biotechnology, Vol. 17, Issue 3 · 5 Oct 2021 · 6,728 accessesView PDFCite
Research ArticleOpen accessIn the keywordsPlatelet Derived Growth Factor-A mRNA Levels in Diabetic and Nondiabetic Subjects at Risk of Coronary Heart DiseaseSalman A.H. AlrokayanCoronary heart disease (CHD) is the number one cause of death in developed countries. We investigated the quantity of platelet derived growth factor-A mRNA (PDGF-A mRNA) among four different groups of diabetic and nondiabetic Saudi subjects (n = 40) at risk of CHD. Total RNA was derived from peripheral blood mononuclear cells (PBMN) and PDGF-A mRNA reverse transcribed into cDNA … …American Journal of Biochemistry and Biotechnology, Vol. 3, Issue 3 · 30 Sep 2007 · 6,683 accessesView PDFCite