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48 results for “anticancer”
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Research ArticleOpen accessIn the abstractCLINICAL EXPERIENCE OF CANCER IMMUNOTHERAPY INTEGRATED WITH OLEIC ACID COMPLEXED WITH DE-GLYCOSYLATED VITAMIN D BINDING PROTEINEmma Ward, Rodney Smith, Jacopo J.V. Branca et al.Proteins highly represented in milk such as α-lactalbumin and lactoferrin bind Oleic Acid (OA) to form complexes with selective anti-tumor activity. A protein present in milk, colostrum and blood, vitamin D binding protein is the precursor of a potent Macrophage Activating Factor (GcMAF) and in analogy with other OA-protein complexes, we proposed that OA-GcMAF could demonstrate a greater immunotherapeutic activity … …American Journal of Immunology, Vol. 10, Issue 1 · 8 Mar 2014 · 13,186 accessesView PDFCite
Research ArticleOpen accessIn the abstractPotential Cancer Chemopreventive Activity of Styryllactones from Goniothalamus marcaniiChalong Mahiwan, Mongkol Buayairaksa, Narong Nuntasaen et al.Goniothalamus plants belonging to the family Annonaceae are found in Thailand and have been used as Thai traditional medicines. Members of this family are rich in a wide variety of biological active compounds including alkaloids, acetogenins and styryllactones. The present research described phytochemical study of the leaves and twigs of G. marcanii together with their cytotoxicity. The G. marcanii was … …American Journal of Applied Sciences, Vol. 10, Issue 1 · 26 Jan 2013 · 7,679 accessesView PDFCite
Research ArticleOpen accessIn the abstractQuercetin in Dimethyl Benzanthracene Induced Breast Cancer in RatsNatla Sashidhar Reddy, Parthasarathy Nirmala, Natesan Chidambaram, Pammi Ashok kumarProblem statement: Vincristine a commonly used anticancer agent in the treatment of breast cancer results in serious adverse effects like teratogenicity, neurotoxicity and carcinogenicity on long term use. Drug resistance is also a common problem encountered with vincristine. Hence the effect of flavonol quercetin, a known antioxidant with no known documented adverse effect was tried in treatment of DMBA induced … …American Journal of Pharmacology and Toxicology, Vol. 7, Issue 2 · 30 Jul 2012 · 8,138 accessesView PDFCite
Research ArticleOpen accessIn the abstractFocal Adhesion Kinase: An Old Protein with New RolesAtul Kumar Pandey, Sonal Somvanshi, Vivek Pratap SinghFocal adhesion kinase, FAK is a tyrosine kinase which is prominently localized to focal adhesions and therefore its name, is an indispensable protein in integrin signaling. Since the discovery of FAK, this tyrosine kinase had been shown to regulate a variety of cell behavior like cell migration, proliferation, apoptosis and metastasis which makes this molecule at a centre stage of … …OnLine Journal of Biological Sciences, Vol. 12, Issue 1 · 13 Mar 2012 · 8,439 accessesView PDFCite
Research ArticleOpen accessIn the abstractUnderstand the Role of Natural KillerHan Yuen Lam, Swee Keong Yeap, Noorjahan Banu Alitheen et al.Problem statement: Immunosuppression is a common approach for pathogens or cancer to escape from immune system of the infected host. Some of the antimicrobe or anticancer drugs may also weaken the body immune system. Among various types of immune cell, natural killer cells are the key component of the innate immunity which plays an important role in first line defense … …American Journal of Immunology, Vol. 6, Issue 4 · 5 Aug 2011 · 7,935 accessesView PDFCite
Research ArticleOpen accessIn the abstractUncommon Toxicologic Profile at Toxic Doses of CPI-613 (an Agent Selectively Alters Tumor Energy Metabolism) in Rats and Minipigs Reflects Novel MechanismClaudia Maturo, King C. Lee, Robert Rodriguez, Robert ShorrProblem statement: CPI-613 is a novel anticancer agent and the toxicological profile has not been assessed. Accordingly, the objective of these studies was to thoroughly evaluate the Toxicokinetic (TK) effects of CPI-613 in rats and to compare the toxicological profile of rats to minipigs to determine if there were differences between the two animal species. Approach: These studies involved assessments … …American Journal of Pharmacology and Toxicology, Vol. 5, Issue 4 · 13 Jun 2011 · 9,582 accessesView PDFCite
Research ArticleOpen accessIn the abstractSynthesis, Characterization and Biological Activities of Organotin (IV) Methylcyclohexyldithiocarbamate CompoundsNormah Awang, Ibrahim Baba, Bohari M. Yamin et al.Problem statement: The growing interest in the chemistry of sulphur donor ligands are due to their encouraging anticancer, antibacterial and antifungal activities as well as their widespread industrial application. Dithiocarbamates belong to this class and much attention has been paid to them. Approach: Novel organotin compounds with the molecular formula RmSn[S2CN(CH3)(C6H11)]4-m (where m = 2, R = CH3, C2H5; m … …American Journal of Applied Sciences, Vol. 8, Issue 4 · 18 Apr 2011 · 9,210 accessesView PDFCite
Research ArticleOpen accessIn the abstractRelationship Between Blood Fibrinogen Concentration and Pathological Features of Cancer Patients: A 139-case Clinical StudyDa-Yong Lu, Xue-Liang Chen, Min Huang et al.Angiogenesis and coagulation are among the most consistent host responses to the presence of a malignant tissue. Pathological angiogenesis and coagulation are often occurred in patients with solid tumors, especially in the occurrence of neoplasm metastasis and as targets for anti-metastatic drugs such as antiangiogenesis agents, coagulation-mediated agents and anticancer drugs. Since fibrinogen (Fib) is the most abundant and key … …OnLine Journal of Biological Sciences, Vol. 7, Issue 1 · 4 Sep 2010 · 7,859 accessesView PDFCite
Research ArticleOpen accessIn the abstractAntiproliferative Effects of Alkaloids Isolated from the Tuber of Stephania venosa via the Induction of Cell Cycle Arrest in Mammalian Cancer Cell LinesSirinapa Nantapap, Chatchanok Loetchutinat, Puttinan Meepowpan et al.Problem statement: S. venosa (Menispermaceae) is used in traditional medicine. The constituents of S. venosa belonging to showed remarkable cytotoxic activity. According to previous research, S. venosa contains several alkaloids, such as protoberberine stephanine cyclanoline and N-methylstepholidine, kamaline, (+)-N-carboxamidostepharine, (-)-O-methylstepharinosine, (-)-stepharinosine, aporphine (-)-O-acethylsukhodiamine and oxostephanosine. The chemical and biological investigations of this plant are interesting to bioassay-guided fractionation, particularly Antiproliferative … …American Journal of Applied Sciences, Vol. 7, Issue 8 · 31 Aug 2010 · 8,789 accessesView PDFCite
Research ArticleOpen accessIn the abstractSynthesis and Characterization of Organotin(IV) N-Benzyl-N-Isopropyldithiocarbamate Compounds: Cytotoxic Assay on Human Hepatocarcinoma Cells (HepG2)Normah Awang, Ibrahim Baba, Nor Syaidatul Akmal Mohd Yousof, Nurul Farahana KamaludinProblem statement: Several studies on organotin(IV) dithiocarbamate compounds have been carried out but not on the synthesis and characterization together with cytotoxic assay of organotin(IV) N-benzyl-N-isopropyldithiocarbamate compounds. Approach: Three new organotin(IV) compounds of type N-benzyl-N-isopropyldithiocarbamate have been successfully synthesized by direct reaction between secondary amine with organotin(IV) chloride using in situ method. All the compounds were characterized using elemental analysis, … …American Journal of Applied Sciences, Vol. 7, Issue 8 · 31 Aug 2010 · 8,092 accessesView PDFCite