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Research ArticleOpen accessEvery word in the titleImmunomodulatory and Antioxidant Properties of Kaurenoic Acid on Macrophages of BALB/c in VitroJuliana Aparecida Macri, Suelen Santos da Silva, Milena Menegazzo Miranda et al.Kaurenoic acid has been displaying anti-inflammatory effect described in different models. However, the per se immunomodulatory effects of kaurenoic acid remain to be investigated. Thus, the immunomodulatory and antioxidant effects of kaurenoic acid were investigated in vitro on peritoneal macrophages from BALB/c mice. Kaurenoic acid induced per se the production of pro-inflammatory cytokines such as TNFα, IL-1β and IFN-γ while … …American Journal of Immunology, Vol. 10, Issue 4 · 16 Feb 2015 · 7,883 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleThe Effect of Humic Acid on the Content of Trace Element in MitochondriaDaniel Žatko, Janka Vašková, Ladislav Vaško, Peter PatlevičBased on our previous in vitro studies which pointed to the antioxidant properties of humic acids especially concerning radical scavenging activities and ability to maintain the redox system in the cell, an addition of 0.6% humic acid into the diet of farm chicken for 42 days was evaluated. The administration of humic acids have a positive effect on the antioxidant … …American Journal of Animal and Veterinary Sciences, Vol. 9, Issue 4 · 29 Jan 2015 · 7,984 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleSodium L-Glutamate-Induced Physiological Changes in Lactobacillus Brevis NCL912 During GABA Production Under Acidic ConditionsGui-Dong Huang, Jian Mao, Zhongwei Ji, Askaer AlatiPrevious studies showed that γ-Aminobutyric Acid (GABA) can protect some GABA-producing bacteria against acid stress through glutamate decarboxylation. However, the acid stress mechanism is a comprehensive network related to numerous genes and proteins. Other than the Glutamate Decarboxylase (GAD)/GABA antiporter system, limited information is available about the physiological modifications that occur in Lactobacillus brevis during GABA production under acidic conditions. … …American Journal of Biochemistry and Biotechnology, Vol. 10, Issue 4 · 22 Dec 2014 · 7,321 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleDrug-Protein Interactions for Clinical Research by Nucleic Acid Programmable Protein Arrays-Quartz Crystal Microbalance with Dissipation Factor Monitoring Nanoconductometric AssayClaudio Nicolini, Rosanna Spera, Nicola Luigi Bragazzi, Eugenia PechkovaConductometric monitoring of drug-gene and drug-protein interactions is of fundamental importance in the field of molecular pharmacology. Here, we present our main findings and characterizations of an important antiblastic used in neuro-oncology (Temozolomide), interacting with selected proteins that represent predictive biomarkers of the rate survival of the patients, of the outcome of chemotherapy and resistance to drug itself (namely, BRIP1 … …American Journal of Biochemistry and Biotechnology, Vol. 10, Issue 3 · 17 Nov 2014 · 8,506 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleAMINO ACID TRANSPORTERS IN DRUG DISCOVERYMariafrancesca Scalise, Lorena Pochini, Michele Galluccio, Cesare IndiveriAdministered drugs interact with membrane transporters of epithelia, Blood Brain Barrier and other districts influencing their delivery and efficacy. Drugs can also be used as inhibitors of transporters involved in human pathology. Drug-transporter interactions are responsible of off-target effects contributing to toxicity. High Throughput Screening technologies increased the potential applications in therapy or in predicting side effects. These strategies will … …Current Research in Drug Discovery, Vol. 1, Issue 1 · 2 Oct 2014 · 7,099 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleMOLECULAR SWITCH THAT CONTROLS THE FLUX OF LINOLEIC ACID INTO N-6 OR N-3 POLYUNSATURATED FATTY ACIDS IN MICROORGANISMSMingxuan Wang, Jianxin Chen, Huaiyuan Zhang, Yuanda SongPolyunsaturated Fatty Acids (PUFA) of the n-6 and n-3 series play important roles in nutrition. Microorganisms are important sources of n-6 and n-3 fatty acids; however, most produce either n-6 or n-3 fatty acids as the major PUFAs and very few produce both. This differential production suggests that PUFAs metabolic pathway is strictly controlled in microorganisms. The major pathway of … …American Journal of Biochemistry and Biotechnology, Vol. 10, Issue 2 · 2 Jul 2014 · 7,131 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleASCORBIC ACID FOLIIAR SPRAY COUNTERACTING EFFECT OF SALINITY ON GROWTH, NUTRIENTS CONCENTRATIONS, PHOTOSYNTHESIS, ANTIOXIDANT ACTIVITIES AND LIPID PEROXIDATION OF BEAN (PHASEULUS VULGARIS L.) CULTIVARSZeinab A. Salama, El-Zanaty A.A. Abou El-Nour, Mohamed M. El Fouly, Alaa A. GaafarA water culture experiment was carried out in the Department of Fertilization Technology at National Research Centre, Cairo, Egypt, to investigate the effect of Ascorbic Acid (AsA) foliar application and salinity stress (100 ppm and 100 mmoL NaCl) on growth, nutrients concentration and some biochemical parameters of two kidney bean (Phaseulus Vulgaris L.) cultivars. Salinity caused significant reduction in growth … …American Journal of Agricultural and Biological Sciences, Vol. 9, Issue 3 · 16 May 2014 · 7,900 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleFATTY ACIDS PATTERN OF OLIVE OIL UNDER ORGANIC FARMINGNasab Al-Rawashdeh, Fawzi Al-SheyabOrganic farming is considered as a mitigation strategy to face adverse effect of climate change and Consumers’ increasing their need for safe and quality food has motivated this research study. The olive oil of the Roman olive trees (Landrace) Olea Europea belong to the Oleaceae family growing under organic farming (in the transition period) conditions in Jordan Ajlun area was … …American Journal of Environmental Sciences, Vol. 10, Issue 2 · 16 Apr 2014 · 7,343 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleCLINICAL EXPERIENCE OF CANCER IMMUNOTHERAPY INTEGRATED WITH OLEIC ACID COMPLEXED WITH DE-GLYCOSYLATED VITAMIN D BINDING PROTEINEmma Ward, Rodney Smith, Jacopo J.V. Branca et al.Proteins highly represented in milk such as α-lactalbumin and lactoferrin bind Oleic Acid (OA) to form complexes with selective anti-tumor activity. A protein present in milk, colostrum and blood, vitamin D binding protein is the precursor of a potent Macrophage Activating Factor (GcMAF) and in analogy with other OA-protein complexes, we proposed that OA-GcMAF could demonstrate a greater immunotherapeutic activity … …American Journal of Immunology, Vol. 10, Issue 1 · 8 Mar 2014 · 13,186 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleBONE MEAL AS ALTERNATIVE TREATMENT FOR ACIDIC AND METAL CONTAMINATED ACID MINE DRAINAGE WATER EFFLUENT: LAB SCALECarolyn Payus, Olga David, Moh Pak YanThe typical methods of treatment for acidic and metal contaminated water effluent such as the Acid Mine Drainage (AMD) will always focus on either civil engineering methods, such as disposal, excavation, drainage and encapsulation or process based technologies such as effluent washing and treatment. These techniques are not environmental friendly, costly and unsustainable, thus environmental damaging. Nowadays, there is a … …American Journal of Environmental Sciences, Vol. 10, Issue 1 · 3 Mar 2014 · 7,979 accessesView PDFCite