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Research Article · Open access · Published 16 February 2015

Immunomodulatory and Antioxidant Properties of Kaurenoic Acid on Macrophages of BALB/c in Vitro

Juliana Aparecida Macri1, Suelen Santos da Silva1, Milena Menegazzo Miranda1, Natalia Yoshie Kawakami1, Thiago Hideki Hayashida1, Tiago Bervelieri Madeira1, Suzana Lucy Nixdorf1, Vinicius Ricardo Acquaro Junior1, Sérgio Ricardo Ambrósio2, Waldiceu Aparecido Verri Jr1, Rubens Cecchini1, Ivete Conchon-Costa1, Nilton Syogo Arakawa1 & Wander Rogério Pavanelli1

American Journal of Immunology, Volume 10, Issue 4, pp. 183–188 · doi.org/10.3844/ajisp.2014.183.188

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Abstract

Kaurenoic acid has been displaying anti-inflammatory effect described in different models. However, the per se immunomodulatory effects of kaurenoic acid remain to be investigated. Thus, the immunomodulatory and antioxidant effects of kaurenoic acid were investigated in vitro on peritoneal macrophages from BALB/c mice. Kaurenoic acid induced per se the production of pro-inflammatory cytokines such as TNFα, IL-1β and IFN-γ while also increased the levels of IL-10. There was also reduction of NO production and induction of anti-oxidant profile. Therefore, in addition to inhibiting inflammation, kaurenoic acid presents immunomodulatory effects per se.

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Macri, J. A., Silva, S. S. D., Miranda, M. M., Kawakami, N. Y., Hayashida, T. H., Madeira, T. B., Nixdorf, S. L., Junior, V. R. A., Ambrósio, S. R., Jr, W. A. V., Cecchini, R., Conchon-Costa, I., Arakawa, N. S. & Pavanelli, W. R. (2014). Immunomodulatory and Antioxidant Properties of Kaurenoic Acid on Macrophages of BALB/c in Vitro. American Journal of Immunology, 10(4), 183–188. https://doi.org/10.3844/ajisp.2014.183.188

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Immunomodulatory and Antioxidant Properties of Kaurenoic Acid on Macrophages of BALB/c in VitroAmerican Journal of Immunology · Volume 10, Issue 4 · pp. 183–188 · CC BY 3.0Download