48 results for “Protein residue”

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Research ArticleOpen accessIn the abstractIntrinsically Unstructured Proteins: Potential Targets for Drug DiscoveryPathan Salma, Chintan Chhatbar, Sriram SeshadriProblem statement: The function of a protein is dependent on its three-dimensional structure. However, numerous proteins lacking intrinsic globular 3D structure under physiological conditions had been recognized. These proteins are frequently involved in some of the most critical cellular control mechanisms and it appears that their rapid turnover, aided by their unstructured nature in the unbound state, provides a level … …American Journal of Infectious Diseases, Vol. 5, Issue 2 · 30 Jun 2009 · 7,578 accessesView PDF Cite

Research ArticleOpen accessIn the abstractImproving Protein 3D Structure Prediction Accuracy using Dense Regions Areas of Secondary Structures in the Contact MapAmer F. Al-Badarneh, Mohammad A. Khalil, Mo'taz A. Al-HamiProblem Statement: The protein folding problem is a fundamental problem in structural molecular biology. This problem describes how a protein is transformed from its primary sequence (i.e., amino acid sequence) into the three dimensional structure (3D structure) for this sequence that determines the function of the protein. The 3D structure of a protein can be represented using a square symmetrical … …American Journal of Biochemistry and Biotechnology, Vol. 4, Issue 4 · 31 Dec 2008 · 7,533 accessesView PDF Cite

Research ArticleOpen accessIn the abstractNimble Protein Sequence Alignment in Grid (NPSAG)K. Somasundaram, S. RadhakrishnanIn Bio-Informatics application, the analysis of protein sequence is a kind of computation driven science which has rapidly and quickly growing biological data. Also databases used in these applications are heterogeneous in nature and alignment of protein sequence using physical techniques is expensive, slow and results are not always guaranteed/accurate. So this application requires cross-platform, cost-effective and more computing power … …Journal of Computer Science, Vol. 4, Issue 1 · 31 Jan 2008 · 6,921 accessesView PDF Cite

Research ArticleOpen accessIn the abstractIn silico Modeling of α1A-Adrenoceptor: Interaction of its Normal and Mutated Active Sites with Noradrenaline as well as its Agonist and AntagonistRamchandran Vijayan, Naidu Subbarao, Birendra Nath MallickNoradrenaline, like most other neurotransmitters, acts through various adrenoceptor subtypes. The structure and active site of adrenoceptors for the binding of noradrenaline were unknown, however, such information are crucial for understanding the molecular mechanism of action of neurotransmitters, including noradrenaline, in health and disease as well as for drug designing. In this in silico study, we modeled the α1A-adrenoceptor; a … …American Journal of Biochemistry and Biotechnology, Vol. 3, Issue 4 · 31 Dec 2007 · 7,140 accessesView PDF Cite

Research ArticleOpen accessIn the abstractPrediction of a Putative Functional Region in the Human Bax Protein by Computational AnalysisMaría Sánchez-Aguilar, Laurence A. Marchat, Absalom ZamoranoStructural domains are relevant elements for interactions between Bcl-2 family members to regulate apoptosis and cell survival. Although BH1-BH4 domains can be identified by their sequence and selective occurrence in Bcl-2-family members, structural regions have not been entirely determined yet. The functional residues of Bax, the most representative pro-apoptotic protein of the human Bcl-2 family, remain almost unknown. Here, we … …American Journal of Infectious Diseases, Vol. 3, Issue 2 · 30 Jun 2007 · 7,230 accessesView PDF Cite

Research ArticleOpen accessIn the abstractThe Meaning of a Redundant Codon: There is Protein Folding Information in Nucleic Acids in Addition to the Genetic CodeJan C. Biro, Josephine M.K. BiroAll the information necessary for protein folding is supposed to be present in the amino acid sequence. It is still not possible to provide specific ab initio structure predictions by bioinformatical methods. It is suspected that additional folding information is present in protein coding nucleic acid sequences, which is not represented by the known genetic code. Nucleic acid subsequences comprising … …American Journal of Biochemistry and Biotechnology, Vol. 2, Issue 1 · 31 Mar 2006 · 8,292 accessesView PDF Cite

Research ArticleOpen accessIn the abstractTowards Identifying Immunogenic Targets in Visceral Leishmaniasis: Role of 17kDa and 63kDa PhosphoproteinsShubhankar K Singh, Sanjiva Bimal, Diwakar S. Dinesh et al.We observed predominant phosphorylation at Protein Kinase C (PKC-α) residue in seven immunoreactive proteins of virulent Leishmania donovani parasites. These phosphoproteins were tested for their ability to stimulate T-cells for secretion of Macrophage Migration Inhibition Factor (MIF) in comparision to crude soluble antigen in Visceral Leishmaniasis (VL) patients. Two of these phosphorylated L. donovani antigens led Leishmania to present these … …American Journal of Immunology, Vol. 1, Issue 3 · 30 Sep 2005 · 6,756 accessesView PDF Cite

Research ArticleOpen accessIn the abstractEffects of Wheat Bran, EM Bacteria, Ammonium Nitrate and Fungal Additives on Fermentation and Forage Quality of Rice Straw SilageBin Yang, Jiahuan Liu, Dongmei Ma et al.The global ruminant industry is constrained by a persistent shortage of high-quality roughage, thus rendering the bioconversion of agricultural residues, such as rice straw, a critical priority. Nevertheless, the high lignification, silicification, and nitrogen deficiency of rice straw pose significant biological barriers to traditional ensiling. This study investigated the impact of various additives on rice straw silage quality. Six treatments … …American Journal of Biochemistry and Biotechnology, Vol. 22, Issue 3 · 30 Sep 2026 · 642 accessesView PDF Cite

Research ArticleOpen accessIn the abstractSynergistic Effects of Wheat Bran and Inoculants on Fermentation and Nutritional Quality of Soybean Straw SilageLie Yang, Rundong Qin, Jiahuan Liu et al.The efficient valorisation of lignocellulosic biomass from soybean straw into high-quality silage remains a pressing challenge for sustainable livestock production. This study employed a 3×3 factorial design to systematically investigate the interactive effects between wheat bran additions (0%, 10%, 20% of fresh weight) and microbial inoculant regimes (control, Effective Microorganisms, EM+Trichoderma longibrachiatum) on soybean straw silage quality. Two-way ANOVA revealed … …American Journal of Biochemistry and Biotechnology, Vol. 22, Issue 2 · 1 Jul 2026 · 1,109 accessesView PDF Cite

Research ArticleOpen accessIn the abstractTHE USAGE OF ANIMAL AND VEGETABLE ORIGIN RAW MATERIALS COMBINATORICS IN MEAT PRODUCTS OF &#34HALAL&#34 CATEGORY DEVELOPMENTIvan F. Gorlov, Oksana B. Gelunova, Tatiana M. Giro, Ekaterina P. MirzayanovaIntegrated researches aimed to develop technologies and recipes for meat products of &#34Halal&#34 category using seed fat and Milk Protein-Carbohydrate Concentrate (MPCC) represent a new generation of scientific and practical interest. In this connection, the authors propose technologies and recipes for meat products of &#34Halal&#34 category, designed on the basis of rational combinatorics of animal and vegetable origin raw materials, … …American Journal of Agricultural and Biological Sciences, Vol. 9, Issue 4 · 15 Oct 2014 · 7,651 accessesView PDF Cite