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48 articles for “Mice Model”
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Research ArticleOpen accessIn the abstractEffect of Exercise Training on Adiponectin Receptor Expression and Insulin Resistance in Mice Fed a High Fat DietNaglaa Fathy Alhusseini, Nasr Arafat Belacy, Enas Mohammed Kasem, Mona Maher AllamProblem statement: Adiponectin is an adipocyte secreted hormones, exerts its effects via the specific receptors. AdipoR1 and adipoR2 and plays a pivotal role in lipid and glucose metabolism. Approach: We investigated the effect of increased physical activities on insulin resistance and if this effect is modulated through adiponectin receptor expression. Results: We also assessed the effect of High Fat Diet … …American Journal of Biochemistry and Biotechnology, Vol. 6, Issue 2 · 30 Jun 2010 · 9,951 accessesView PDFCite
Research ArticleOpen accessIn the abstractFoxp3-Mediated Immunity of Human Pancreatic Cancer Cell Line PANC-1Renxi Wang, Gencheng Han, Jianan Wang et al.Problem statement: More and more evidences have shown that human cancer cells can express Foxp3, the regulatory T cell-associated transcription factor. The role of Foxp3 in human cancer cells is still unclear. We detected Foxp3 expression in human pancreatic cancer cell line PANC-1. SiRNA assays showed that Foxp3 expression suppressed the expression of TGF-β and IL-10 which could induce immune … …American Journal of Immunology, Vol. 5, Issue 4 · 11 Jan 2010 · 7,363 accessesView PDFCite
Research ArticleOpen accessIn the abstractEvidence of Oxidative Stress in Autism Derived from Animal ModelsXue Ming, Michelle A. Cheh, Carrie L. Yochum et al.Autism is a pervasive neurodevelopmental disorder that leads to deficits in social interaction, communication and restricted, repetitive motor movements. Autism is a highly heritable disorder, however, there is mounting evidence to suggest that toxicant-induced oxidative stress may play a role. The focus of this article will be to review our animal model of autism and discuss our evidence that oxidative … …American Journal of Biochemistry and Biotechnology, Vol. 4, Issue 2 · 30 Jun 2008 · 7,115 accessesView PDFCite
Research ArticleOpen accessIn the abstractUltrastructural and Immunological Characterization of Hepatitis C Core Protein-DNA Plasmid ComplexesNelson Acosta-Rivero, Yaraima Aguilera, Viviana Falcon et al.Recently, it has been shown that a truncated HCV core (HCcAg) variant, covering the first 120 aa (HCcAg.120), interacts with plasmid DNA vaccine (pIDKE2), encoding the HCV structural proteins (HCcAg, E1 and E2). In the present work, HCcAg.120-pIDKE2 complexes, forming heterogeneous packaged structures, were visualized using a negative stain/rotary shadow technique. Interestingly, 72 hours after intramuscular injection of HCcAg.120-pIDKE2 complexes … …American Journal of Immunology, Vol. 2, Issue 3 · 30 Sep 2006 · 6,743 accessesView PDFCite
Research ArticleOpen accessIn the abstractLoss of Morphine-induced Suppression of NK Cell activity and T-cell Functions in µ-Opioid Receptor Knockout MiceRichard J. Weber, Ricardo Gomez-Flores, Ichiro Sora, George R. UhlIn vivo administration of µ-opioid receptor selective agonists to various species is known to suppress lymphocyte, NK cell, and macrophage functions, in addition to mediate pain relief and euphoria. Using a mouse model in which the µ-opioid receptor gene was disrupted by targeted homologous recombination, we explored the involvement of this receptor in natural killer (NK) cell activity and T … …American Journal of Immunology, Vol. 2, Issue 2 · 30 Jun 2006 · 6,937 accessesView PDFCite
Research ArticleOpen accessIn the abstractMaterno-Foetal Transmission of Murine Toxoplasmosis after Oral InfectionJamal Hafid, Bahrie Bellete, Pierre Flori et al.The effect of maternofoetal transmission of T. gondii as measured by the mortality rate in the mother, the foetus and the neonate were studied in the mouse model OF1. Ninety six female mice divided into two groups of 48 were infected with the Prugniaud strain before or after mating. When the time of mating was near the day of infection … …American Journal of Immunology, Vol. 1, Issue 1 · 21 Mar 2005 · 7,210 accessesView PDFCite
Research ArticleOpen accessIn the abstractThe Antinociceptive Effects of Central and Peripheral Administration of Peganum harmala L. Extracts in Animal ModelsRachida Aboufatima, Loubna Farouk, Mehdi Ait Laaradia et al.The medicinal plant Peganum harmala has been used in traditional Moroccan medicine to accelerate the healing process of various diseases and to relieve the pain. The antinociceptive effect of the Aqueous (AE), Dichloromethane (DE) and Butanolic (BE) extracts of the Peganum harmala L. was tested in mice and rats by chemical and thermal models. Plant seed extracts were given intraperitoneally … …OnLine Journal of Biological Sciences, Vol. 21, Issue 2 · 29 May 2021 · 6,423 accessesView PDFCite
Research ArticleOpen accessIn the abstractProtection against Lipopolysaccharide-induced Death by An Anti-Interleukin-6 Monoclonal AntibodyBailin Liang, Debra Gardner, Don Griswold, Xiao-yu R. SongSepticemia is frequently associated with serious complications and high mortality despite recent advances in treatment with antibacterial agents. Infectious organisms or their soluble products initiate septic shock through a complex cytokine cascade. Lipopolysaccharide (LPS) induced excessive production of inflammatory cytokines is regarded as a model of septic shock. Experiments of LPS-induced excessive cytokine production were conducted in Balb/c mice for … …American Journal of Immunology, Vol. 3, Issue 1 · 30 Jun 2007 · 6,856 accessesView PDFCite
Research ArticleOpen accessIn the abstractCpG Oligodeoxynucleotides Debate the Damaging Action of Cisplatin on Immune Cell DNA: A PCR Array Application on Repair Genes ExpressionNaglaa Fathy Alhusseini, Amal Abo El-Fadl, Shabaan Hemada et al.Synthetic Oligodeoxynucleotides (ODN) expressing CpG motifs (CpG-ODN) mimic the immunostimulatory activity of bacterial DNA and are commonly used to activate Toll Like Receptor 9 (TLR9) for therapeutic applications. CpG-ODN can counteract the activity of DNA-damaging chemotherapy and radiation therapy on immune cell and enhance immunity in preclinical mouse models. We hypothesized that these actions of CpG-ODN on immune cells are … …American Journal of Biochemistry and Biotechnology, Vol. 12, Issue 3 · 27 Jul 2016 · 7,625 accessesView PDFCite
Research ArticleOpen accessIn the abstractImmunomodulatory and Antioxidant Properties of Kaurenoic Acid on Macrophages of BALB/c in VitroJuliana Aparecida Macri, Suelen Santos da Silva, Milena Menegazzo Miranda et al.Kaurenoic acid has been displaying anti-inflammatory effect described in different models. However, the per se immunomodulatory effects of kaurenoic acid remain to be investigated. Thus, the immunomodulatory and antioxidant effects of kaurenoic acid were investigated in vitro on peritoneal macrophages from BALB/c mice. Kaurenoic acid induced per se the production of pro-inflammatory cytokines such as TNFα, IL-1β and IFN-γ while … …American Journal of Immunology, Vol. 10, Issue 4 · 16 Feb 2015 · 7,883 accessesView PDFCite