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92 results for “Drug-Resistance”
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Literature ReviewOpen accessIn the abstractMitochondrial Dysfunction Model in the Pathogenesis of Inflammatory Response Development in ObesityAlexander Blagov, Varvara Orekhova et al.Obesity is one of the growing problems of modern society. Although currently used methods of treating obesity, including diet, exercise, and drug therapy, have shown their applicability to more effectively combat obesity, an understanding of the pathogenesis of this disease is required. One of the insufficiently studied factors in the pathogenesis of obesity is the development of mitochondrial dysfunction understanding … …OnLine Journal of Biological Sciences, Vol. 24, Issue 1 · 19 Nov 2023 · 4,933 accessesView PDFCite
Research ArticleOpen accessIn the abstractUse of Novel Triphenyltin (IV) Dithiocarbamate Compounds in Assessing the Cytotoxicity and Mode of Cell Death of Acute Lymphoblastic Leukemia Cell Lines, CCRF CEM (CCL-119)Normah Awang, Nur Hidayah Hasrin, Nurul Farahana Kamaludin et al.Chemotherapy and radiotherapy are often used to treat Acute Lymphoblastic Leukemia (ALL). However, the resistance problem of treatment using the current drug in ALL patients has decreased the effectiveness of such therapy. Therefore, a study needs to be conducted to identify the potential of new anticancer agents. Organotin (IV) dithiocarbamate, an organometallic compound, causes toxic effects on cancer cells in … …OnLine Journal of Biological Sciences, Vol. 23, Issue 2 · 10 Mar 2023 · 5,159 accessesView PDFCite
Research ArticleOpen accessIn the abstractEvaluation of Anthelmintics Resistance Against Gastrointestinal Parasites Infection in Awassi Sheep in Jordan and The use of Alternative Herbal AnthelmenticsFiras Mahmoud Hayajneh, Hosam Hani Titi, Mufeed Awni Alnimer, Rabie IrshaidThis study aimed to uncover the prevalence of anthelmintic resistance in ovine gastrointestinal nematodes in middle and north Jordan and to check the in vivo anthelmintic efficacy of apple cider vinegar drench and ginger powder. For this purpose a parasitological study was designed, which used fecal egg count reduction test Two hundred seventy ewes were enrolled in this study, twenty … …American Journal of Animal and Veterinary Sciences, Vol. 14, Issue 2 · 14 May 2019 · 8,058 accessesView PDFCite
Research ArticleOpen accessIn the abstractOutcomes and Risk Factors Associated with Drug Resistant Tuberculosis in Rural Eastern Cape, South AfricaCarine Bokop Fotso, Sandeep D. Vasaikar, Teke ApalataWith the emergence of Multidrug-Resistant (MDR) and Extensively Drug-Resistant (XDR) strains of Mycobacterium tuberculosis, Tuberculosis (TB) has become an even greater threat in South Africa (SA). The study sought to investigate the resistance pattern of anti-TB drugs in M. tuberculosis as well as to determine the associated risk factors and outcomes for MDR-TB and XDR-TB. A descriptive study was conducted … …American Journal of Infectious Diseases, Vol. 14, Issue 2 · 15 Aug 2018 · 9,536 accessesView PDFCite
EditorialOpen accessIn the abstractFocalize the Structure of Myd88 in TLR Signaling Pathway to Modulate Innate Immune Response: New Target for Old DiseasesShuai Xing, Ping ZhouAll diseases have their Achilles’ Heel to target and this is especially true for immunorelated diseases which must be treated by targeting the immune system somewhere and somehow correctly. In the most recent decade, immunologists recognized that the Toll-Like Receptor (TLR) signaling pathway in innate immune system plays a double-edged role in the pathogenesis of many notorious diseases. Although the … …American Journal of Immunology, Vol. 13, Issue 3 · 6 Sep 2017 · 7,862 accessesView PDFCite
Research ArticleOpen accessIn the abstractSildenafil in the Treatment of Postoperative Hypoxemia with High Resistance in Cyanotic Congenital Heart DiseaseZhou Jiawang, Lv Yong, Hu Zhendong et al.This study was designed to determine the effect of sildenafil treatment on postoperative hypoxemia with high resistance in cyanotic congenital heart disease. A total of 247 cases of cyanotic congenital heart disease were operated on from May 2006 to August 2014. Only 45 cases exhibited postoperative hypoxemia after symptomatic treatment. Sildenafil at doses of 0.30-5 mg/kg every 6 h was … …American Journal of Biochemistry and Biotechnology, Vol. 13, Issue 3 · 1 Sep 2017 · 7,682 accessesView PDFCite
Research ArticleOpen accessIn the abstractEffects of Artemisinin-Based Combination Therapies on Lipids and Hepatorenal Circulating Indices in Guinea PigsAbaram Chesa Mankwe, Jonah Sydney Aprioku, Atuboyedia Wolfe ObianimeArtemisinin-based Combination Therapies (ACTs) are employed as first-line agents in malaria chemotherapy. In many malaria endemic areas, ACTs are frequently abused partly due to resistance, poor drug control and inadequate health facilities. This study investigated the effects of prolong administration of Artesunate-Sulfadoxine-Pyrimethamine (ATS-SP), Artesunate-Amodiaquine (ATS-Amod) and Artemether-Lumefantrine (ATM-Lum) on plasma levels of biochemical parameters (AST, ALT, ALP, urea and creatinine) … …American Journal of Pharmacology and Toxicology, Vol. 11, Issue 2 · 3 Apr 2017 · 7,282 accessesView PDFCite
Research ArticleOpen accessIn the abstractDesigning of Disulfide Cyclic Peptide for Inhibiting Polymerase A and B1 (PAC-PB1N) in H1N1 Virus using Molecular Simulation ApproachUsman Sumo Friend Tambunan, Mochammad Arfin Fardiansyah Nasution, Arli Aditya Parikesit et al.The drug resistance A/H1N1 flu virus is emerging rapidly. Therefore, looking for potential therapy is very important. PB2, PB and PA are subunits of viral RNA-dependent RNA polymerase (RdRp). They play an important role in viral replication. The PA and PB1 binding sites can be considered as potential targets for the development of new influenza drugs. The peptide inhibitors can … …OnLine Journal of Biological Sciences, Vol. 16, Issue 3 · 24 Aug 2016 · 7,310 accessesView PDFCite
Research ArticleOpen accessIn the abstractBacteria Contaminants and their Antibiotic Sensitivity from Selected Herbal Medicinal Products from Eldoret and Mombasa, KenyaLucia Keter, Richard Too, Nicholas Mwikwabe et al.Herbal products are used worldwide for the treatment and prevention of various diseases and currently represent a substantial proportion of the global drug market. However, these products have the potential of being contaminated by different microorganisms due to poor hygienic practices during handling, processing and packaging. The main aim of this study was to evaluate microbial quality of herbal products … …Current Research in Microbiology, Vol. 7, Issue 1 · 28 Jan 2016 · 17,160 accessesView PDFCite
Research ArticleOpen accessIn the abstractAntimicrobial Activities of Unconventional Compounds against Some Bacteria Associated with Skin Infections in Humans, Sheep and GoatsIman Shabana, Amira El-AdlyBacterial skin infections are a common problem encountered in clinical practice and causing great economic losses for sheep and goats producers. Increasing multidrug resistance of pathogens paves the way for reconsidering alternative medicine. The present study was carried out to explore the antibacterial activities of different volumes; 5, 25, 50 and 100 µL of gold nanoparticles (NPS) and the aqueous … …American Journal of Applied Sciences, Vol. 13, Issue 1 · 11 Jan 2016 · 8,021 accessesView PDFCite