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273 articles for “Bo Chen”
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Research ArticleOpen accessIn the author namesImpact of Integrated Nursing and Digital Droplet PCR on Bullous Dermatoid Conditions: A Randomized Controlled TrialConghui ChenBullous skin disease is an autoimmune disease characterized by the formation of blisters on the skin or mucous membrane, which seriously impairs the quality of life and overall health. Similar to the research on biomolecules (mechanics of protein interaction), cells (including cell membrane elasticity, cell adhesion, cytoskeletal dynamics, response to mechanical stimulation, cell deformation and cell endoforce transfer) and tissue … …American Journal of Biochemistry and Biotechnology, Vol. 22, Issue 2 · 2 Jul 2026 · 985 accessesView PDFCite
Research ArticleOpen accessIn the author namesImmunomodulatory and Antioxidant Effects of Stachys Japonica Miq. Ethanol Extract on Cyclophosphamide-Induced Immunosuppressed Mice and its Phytochemical CompositionXueping Jiang, Jianglong He, Yanjun Chen, Fang WangStachys japonica Miq. is an edible wild botanical drug and a traditional medicine in China. This study focused on examining the phytochemical profile and antioxidant properties of the ethanol extract of S. japonica Miq (SJEE) in vitro, as well as its immunomodulatory and antioxidant activities in cyclophosphamide (Cy)-induced immunosuppressed mice. The SJEE was analysed by UPLC-HRMS/MS. 36 Polyphenols, including flavonoids, … …American Journal of Biochemistry and Biotechnology, Vol. 22, Issue 1 · 13 Apr 2026 · 1,449 accessesView PDFCite
Research ArticleOpen accessIn the author namesUltrasonic Microwave Assisted Extraction, Chemical Characterization and Antioxidant Activity of Polysaccharides from Fig LeavesBaikangzhe Zheng, Yang Miao, Yi Zhou et al.This study employed ultrasonic-microwave-assisted extraction (UMAE) to isolate water-soluble polysaccharides from fig (Ficus carica L.) leaves (FLPs). Polysaccharide yield was used as the primary index to evaluate extraction efficiency. The effects of material-liquid ratio, microwave power, extraction temperature, and extraction time on polysaccharide yield were systematically investigated through single-factor experiments, followed by response surface methodology optimization. Structural characterization and antioxidant … …American Journal of Biochemistry and Biotechnology, Vol. 21, Issue 4 · 3 Mar 2026 · 1,671 accessesView PDFCite
Research ArticleOpen accessIn the author namesPurification, Structural Characterization and Anti-Aging and Stress Activities of Cordyceps Mycelium Polysaccharides from Paecilomyces HepialiXiaokang Hu, Huixiu Ma, Guicai Chen et al.This study identified and characterized the bioactive polysaccharide components from Cordyceps mycelium powder (CMP) derived from Paecilomyces hepiali, evaluating their anti-aging and stress-protective activities. Initial screening using Drosophila melanogaster revealed that crude Cordyceps polysaccharides (CCP) exhibited comparable effects to CMP and Cordyceps aqueous extracts (CAE) on natural lifespan and UV stress resistance, suggesting CCP as the primary bioactive component. CCP … …American Journal of Biochemistry and Biotechnology, Vol. 21, Issue 4 · 16 Feb 2026 · 1,698 accessesView PDFCite
Research ArticleOpen accessIn the author namesAn AI-Powered Integrated Care Model Combining Traditional Chinese Medicine and Western Medicine for Personalized Alzheimer’s Disease ManagementShurong Li, Yiming Chen, Jin Xu et al.Alzheimer's Disease (AD) gradually reduces memory and cognition. While Western medicine focuses on pharmacological treatments, it frequently ignores holistic factors such as mood and digestion. Traditional Chinese Medicine (TCM) addresses these issues through a wellness-oriented approach. However, the combination of both systems in patient care is uncommon. Current Alzheimer's disease treatments are often siloed, relying solely on Western or alternative … …American Journal of Biochemistry and Biotechnology, Vol. 21, Issue 4 · 16 Feb 2026 · 2,063 accessesView PDFCite
Review ArticleOpen accessIn the author namesAssessing Protein PurityShiva Siddappa, Liang-Yin Ke, Chu-Huang Chen, Gopal Kedihithlu MaratheDetermination of protein purity is crucial, as proteins are frequently used as therapeutic agents and reagents in many biochemical reactions. Additionally, purified protein is necessary for biophysical and structural studies. Assessing protein purity involves examining for impurities or demonstrating their absence. In our experience, a satisfactory answer is seldom obtained when biochemistry students are asked a common question on how … …American Journal of Biochemistry and Biotechnology, Vol. 21, Issue 4 · 9 Feb 2026 · 1,901 accessesView PDFCite
Research ArticleOpen accessIn the author namesDihydroartemisinin Attenuates HBV-Induced Proliferation and Migration in LO2 cells via EMT Pathway ModulationYingde Nong, Caifang Ma, Wei Huang et al.Dihydroartemisinin (DHA), a derivative of artemisinin, possesses well-documented anti-inflammatory properties. This study investigated the inhibitory effects of DHA on hepatitis B virus (HBV)-induced cellular alterations in LO2 cells and elucidated underlying molecular mechanisms. Serum interleukin-6 (IL-6) levels were measured in HBV patients and analyzed for correlations with HBsAg, anti-HBs, and HBeAg. In vitro, LO2 cells were infected with clinical HBV … …American Journal of Biochemistry and Biotechnology, Vol. 21, Issue 3 · 8 Jan 2026 · 2,071 accessesView PDFCite
Research ArticleOpen accessIn the author namesEnhanced Fatty Acid Production in Escherichia coli by Over-Expression of NADPH Generating EnzymesYuanda Song, Yong Q. Chen, Haiqin Chen et al.NADPH is an essential factor for Fatty Acid (FA) biosynthesis. The effect of NADPH generating enzymes [NADP+-dependent malic enzyme (NADP-ME), NADP+-dependent isocitrate dehydrogenase (NADP-IDH), Glucose 6-Phosphate Dehydrogenase (GPD) and 6-Phosphogluconate Dehydrogenase (PGD)] on FA biosynthesis was investigated in an engineered Escherichia coli BL21 △fadE/pTE. Among NADPH-generating enzymes, GPD and ICD increased total FA production by 60 and 16% respectively. Especially … …American Journal of Biochemistry and Biotechnology, Vol. 13, Issue 4 · 23 Oct 2017 · 8,578 accessesView PDFCite
Research ArticleOpen accessIn the author namesUPLC-Q-Exactive Orbitrap-MS Analysis of Anchusa italica Retz. Flowers: Molecular Docking, Dynamics Modeling, and Pharmacokinetics for Cardiovascular DiseaseLinyang Wang, Yan Chen, Ainiwaer Aikemu, Shuge TianThis study builds on prior UPLC-Q-Exactive Orbit rap-MS analyses of Anchusa italica Retz. Flowers (Airfs) to explore their anti-cardiovascular mechanis·ms and key bioactive markers. UPLC-Q-Exactive Orbitrap-MS identified 30 major compounds, including polyphenols and flavonoids with strong antioxidant activity. The potential active ingredients were then screened using Lipinski's rule of five, and a network pharmacology method was employed to construct an … …American Journal of Biochemistry and Biotechnology, Vol. 21, Issue 2 · 25 Oct 2025 · 2,599 accessesView PDFCite
Research ArticleOpen accessIn the author namesStudy of Heat-Treated Steel and Related ApplicationsShu-Ping Chang, Ming-Chen Chen, Jyh-Dong LinNumerous studies conducted after the 921 earthquake in Taiwan in 1999 have reported that because heat-treated steel features relatively unstable mechanics properties, using such steel in welding, bar splicing, or as thread-cutting components in structures may result in lack of resistance to seismic activity. However, nondestructive testing methods that can be used to identify the type of steel delivered to … …American Journal of Engineering and Applied Sciences, Vol. 8, Issue 4 · 30 Oct 2015 · 7,543 accessesView PDFCite