EditorialOpen accessIn the abstractCommentary-How do we Improve Training for Receptor Research?Marilee Ann BenoreThis issue of the American Journal of Biochemistry and Biotechnology features articles about receptor-ligand interactions that are critical to the wellbeing of all living organisms. The importance of the field of receptor research is supported by the large number of articles published in journals, the numerous specialty journals, the international conferences and the percentage of legal drugs on the market … …American Journal of Biochemistry and Biotechnology, Vol. 11, Issue 4 · 8 Dec 2015 · 8,058 accessesView PDFCite
EditorialOpen accessIn the abstractNeutrophil Extracellular Traps as Therapeutic Targets for Inflammatory DiseaseRory R. KoenenNeutrophilic granulocytes, or neutrophils are the most abundant circulating white blood cell and constitute a first line of defense against pathogens. They are characterized by a large polymorphic lobular nucleus and the presence of many secretory granules in their cytoplasm. Neutrophils are essential for a functional host defense, as is evidenced by the occurrence of severe infections in individuals with … …American Journal of Pharmacology and Toxicology, Vol. 9, Issue 4 · 25 Feb 2015 · 8,740 accessesView PDFCite
EditorialOpen accessIn the abstractCRISPR-CAS SYSTEM: A FEASIBLE SOLUTION FOR GETTING RID OF PERSISTENT VIRAL INFECTION?Zhaohua ZhongMany viruses, including DNA and RNA viruses, can persistently replicate in the infected cells and cause a prolonged damage. Herpes viruses can be latent in its host cells. Human Immunodeficiency Virus (HIV) reversely transcripts its RNA genome to DNA and integrates to the host’s chromosome. Hepatitis B Virus (HBV) and Human Papilloma Virus (HPV) persistently stay in the host cells … …Current Research in Virology, Vol. 3, Issue 1 · 10 Nov 2014 · 12,620 accessesView PDFCite
Research ArticleOpen accessIn the abstractNeuronal Functions of Protein Phosphatase 2AHung-Tat Leung, Ning WangReversible protein phosphorylation is a common and important form of protein posttranslational modification which determines the proteins’ activities, substrate specificity and inhibitions or degradations, depending on the specific amino acid residue, or combination of residues, being targeted. While protein phosphorylations by kinases have been well studied, the importance of protein dephosphorylation by phosphatases has emerged over the past two decades … …Neuroscience International, Vol. 4, Issue 2 · 1 Apr 2014 · 7,783 accessesView PDFCite
Research ArticleOpen accessIn the abstractTRANSCRIPTION ACTIVATOR-LIKE EFFECTOR NUCLEASES-AMAZING TOOL FOR GENOME EDITINGAvantika Singh, Vivek Pratap SinghTranscription Activator-Like Effector Nucleases (TALENs) are used to cut specific target DNA sequence in order to knock out a gene or to change its sequence. They are formed by the fusion of TALE protein serving as DNA binding domain along with non-specific DNA cleaving nucleases. Its specificity towards DNA bases in the target sequence is derived from the structure of … …OnLine Journal of Biological Sciences, Vol. 13, Issue 3 · 4 Sep 2013 · 8,000 accessesView PDFCite
Research ArticleOpen accessIn the abstractMicrornas as Double Edged Sword in CancerBaby Joseph, Vrundha M. NairCancer is the leading causes of death world wide. Basically it can be defined as the disease of the cell. One among the mechanism of transfer of a normal cell to cancerous is the alteration in the genetic material DNA. Treatment for cancer remains as a biggest challenge. Here comes the importance of miRNAs. They are endogenous RNA which regulates … …Current Research in Bioinformatics, Vol. 2, Issue 1 · 24 May 2013 · 6,959 accessesView PDFCite
Research ArticleOpen accessIn the abstractA NAPIN PROMOTER ACTIVATES GENE EXPRESSION IN DEVELOPING SEEDS OF LESQUERELLA FENDLERIGrace Q. Chen, Jiann-Tsyh LinLesquerella fendleri produces industrial useful Hydroxy Fatty Acids (HFA) in seed oil. To improve oil and HFA of L. fendleri, it is desirable to use of seed-specific promoters to control the expression of target genes by genetic engineering. A seed-specific promoter fragment, -397 to -1 of a napin gene (PnapA) from Brassic napus was isolated by PCR and constructed to … …OnLine Journal of Biological Sciences, Vol. 12, Issue 3 · 18 Sep 2012 · 7,897 accessesView PDFCite
Research ArticleOpen accessIn the abstractZeta Chain-Associated Protein-70 Expression is a Prognostic Tool in Mature and Precursor B-Cell NeoplasmNadia E. ElMenshawy, Sherin A. Abd ElAziz, Heba A. El Deghadi et al.Problem statement: The Zeta Chain-Associated Protein (ZAP) is a 70-kDa molecule associated with the zeta chain of the CD3 receptor complex of the lymphocyte population. It plays an important role in signaling initiation, activation T-cell receptor, phosphorylation of multiple downstream targets. So that believed as T. lymphocyte specific .Several studies is gathering that the pattern of expression is not lineage … …Current Research in Medicine, Vol. 2, Issue 1 · 9 Jul 2011 · 7,300 accessesView PDFCite
Research ArticleOpen accessIn the abstractThe Influence of Foam Density on Specific Energy Absorption of Rectangular Steel TubesNirut Onsalung, Chawalit Thinvongpituk, Kulachate PainthongProblem statement: In general, the automotive structure is targeted to absorb high impact energy with least mass as much as possible. This is in order to limit the fuel consumption. Therefore, various techniques to increase the energy absorption with less mass increment have been studied for years. One of those techniques is by filling foam in the tube. This study … …Energy Research Journal, Vol. 1, Issue 2 · 31 Oct 2010 · 7,444 accessesView PDFCite
Research ArticleOpen accessIn the abstractAn Adaptive Updating Topic Specific Web Search System Using T-GraphAhmed PatelProblem statement: The main goal of a Web crawler is to collect documents that are relevant to a given topic in which the search engine specializes. These topic specific search systems typically take the whole document's content in predicting the importance of an unvisited link. But current research had proven that the document's content pointed to by an unvisited link … …Journal of Computer Science, Vol. 6, Issue 4 · 30 Apr 2010 · 6,597 accessesView PDFCite