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Literature ReviewOpen accessIn the abstractMitochondrial Dysfunction Model in the Pathogenesis of Inflammatory Response Development in ObesityAlexander Blagov, Varvara Orekhova et al.Obesity is one of the growing problems of modern society. Although currently used methods of treating obesity, including diet, exercise, and drug therapy, have shown their applicability to more effectively combat obesity, an understanding of the pathogenesis of this disease is required. One of the insufficiently studied factors in the pathogenesis of obesity is the development of mitochondrial dysfunction understanding … …OnLine Journal of Biological Sciences, Vol. 24, Issue 1 · 19 Nov 2023 · 4,933 accessesView PDFCite
Research ArticleOpen accessIn the abstractDifferential Gene Expression of Peroxide Resistant Protein (AhpC) in Planktonic and Biofilm State of Uropathogenic Escherichia coli CellsOmar Sadik Shalal, Ani-Simona SevastreThe gastrointestinal tract seems to be the primary reservoir of Uropathogenic Escherichia coli (UPEC) in humans. UPEC strains harbor the Urinary Tract (UT) and cause Urinary Tract Infections (UTI) which might represent a serious threat to human life. To counteract with the damage caused by the Reactive Oxygen Species (ROS), bacterial strains produce various enzymes and proteins like Alkyl hydroperoxide … …American Journal of Biochemistry and Biotechnology, Vol. 19, Issue 3 · 13 Oct 2023 · 5,324 accessesView PDFCite
Research ArticleOpen accessIn the abstractNuclear Factor Erythroid-2-Related Factor 2 (Nrf2) Signalling Pathway and Apoptosis Impact on the Effect of Tetramethylpyrazine against H2O2-Damage in Human Hepatic Cell Line (LO2 Cells)Songbo Guo, Xinglin Han, Baoguo Sun et al.As an active component in traditional Chineseherbal medicine, Tetramethylpyrazine (TMP)played a critical role in the treatment of cardiovascular, cerebrovascular, andeye diseases. In this study, the TMP has obtained from the Chinese herbalmedicine Ligusticum chuanxiong and investigated the protective effects of TMPon oxidative damage in human LO2 cells with the treatment ofdifferent concentrations of TMP. The results showed that TMP reserved … …American Journal of Biochemistry and Biotechnology, Vol. 18, Issue 3 · 6 Sep 2022 · 5,654 accessesView PDFCite
Research ArticleOpen accessIn the abstractPreparation, Identification and Antioxidant Evaluation of Citrullus Colocynthis Root and Fruit Extracts Against Doxorubicin in Male RatsSarah Samir Othman, Gamal M. Hamad, Sabria Abo Zaid Hassan et al.Millions of people are affected by diseases in developing or developed countries. Citrullus colocynthis is a high-antioxidant wildflower, it is healthy to eat and may be used as a source of energy or medication. The goal of this research was to conduct a phytochemical analysis of Citrullus colocynthis fruit extract, which is abundant in Egypt. Different extracts from that plant … …OnLine Journal of Biological Sciences, Vol. 22, Issue 1 · 8 Feb 2022 · 6,243 accessesView PDFCite
Research ArticleOpen accessIn the abstractSelenium Enriched Peanut Protein Alleviates Alcohol-Induced Liver Damage in Mice by Modulating the Composition of the Gut MicrobiotaLin Gao, Jiawei Yuan, Yuhuan Cheng et al.Alcohol Use Disorder (AUD) is one of leading external causes of mortality. Selenium-enriched Peanut Protein (SePP) is a type of Se compound present in Se-enriched plants. Our previous studies showed that SePP possesses potential therapeutic properties and could alleviate alcohol-induced AML-12 cytotoxicity. It spurred us to determine the underlying mechanisms and roles of SePP on gut microbiota. Here, ICR mice … …American Journal of Biochemistry and Biotechnology, Vol. 17, Issue 4 · 23 Dec 2021 · 6,230 accessesView PDFCite
Research ArticleOpen accessIn the abstractCell Longevity of Yeast Saccharomyces cerevisiae by Clove Bud Extract Treatment May Occur in Sirtuin-Independent PathwayZahrah Qolbaina Ariybah, Rika Indri Astuti, Sri ListiyowatiAccumulation of free radicals causes cell damage that leads to a phenomenon called aging. Antioxidant application is one potential strategy to avoid the damage of free radical accumulation. Many reports resume that clove, one of Indonesia’s spices, contain high amount of antioxidant. Our previous research had proven that clove extract could extend longevity in yeast Saccharomyces cerevisiae. However, cellular mechanism … …OnLine Journal of Biological Sciences, Vol. 21, Issue 3 · 3 Aug 2021 · 6,659 accessesView PDFCite
Research ArticleOpen accessIn the abstractGlutathione S-transferase (T1 & M1) Null Genotypes as Risk Determinants in Sudanese for Developing Type Two Diabetes MellitusGaafar Mahmoud, Hisham Mohamed Abdelrahim, Abed Al Salam Aljahmany, Eltayeb Mohamed Ahmed TayrabGlutathione S-transferases (GSTT1 and GSTM1) are globular proteins responsible for the detoxification of xenobiotics and the prevention of oxidative damage. Functional polymorphisms of the antioxidant glutathione and enzymes have a role in the pathogenicity of T2DM and its complications. The present study is aimed to assess association between GSTM1 and GSTT1 genetic polymorphisms with T2DM in Sudanese people. This case-control … …American Journal of Biochemistry and Biotechnology, Vol. 16, Issue 3 · 16 Oct 2020 · 6,423 accessesView PDFCite
Research ArticleOpen accessIn the abstractEffect of Cadmium on Worker Ovary Morphology of Bombus morio (Hymenoptera: Bombini)Fábio Camargo Abdalla, Marina Pedrosa, Caio Eduardo da Costa Domingues, Paulo José BalsamoBees are valuable bioindicators, providing information regarding environmental conditions through different kinds of analyses. Therefore, the effect of cadmium on the morphology of ovaries of Bombus morio workers was used to study a concentration considered environmentally safe (1 ppb) in Brazil. Workers of the same estimated age exposed for 48 h to 1 ppb cadmium showed extensive morphological changes in … …American Journal of Agricultural and Biological Sciences, Vol. 13, Issue 1 · 10 Apr 2018 · 9,140 accessesView PDFCite
Research ArticleOpen accessIn the abstractOxidative Status of Boar Semen during StorageEraldo Zanella, Ricardo Zanella, Márcia Rósula Poetini et al.The intensification of the use of artificial insemination in the swine industry has increased the interest to develop proper conditions to store semen better for longer periods of time without affecting its fertility. Trolox is a vitamin E analog with antioxidant property to prevent oxidative stress. Therefore, the objective of this study was to evaluate the Trolox antioxidant capacity on … …American Journal of Biochemistry and Biotechnology, Vol. 12, Issue 2 · 31 May 2016 · 7,550 accessesView PDFCite
Research ArticleOpen accessIn the abstractEffect of Combined Fenofibrate and Nicotinamide on Oxidative Stress and Inflammatory Cytokines Involved in Cisplatin-Induced Nephrotoxicity in RatsOmaima M. Abd Allah, Abeer A.I. Sharaf El-Din, Fouad El DebakeyCisplatin (Cis) is an anticancer drug, which is accompanied with major side effects including nephrotoxicity. The current study was performed to assess the possible prophylactic effects of fenofibrate (FEN), Nicotinamide (NAM) and their combination on oxidative stress and inflammatory cytokines associated with cisplatin-induced renal damage. Rats were randomly divided into seven groups (8 each) as follows; control group; FEN group … …American Journal of Pharmacology and Toxicology, Vol. 9, Issue 4 · 9 Jan 2015 · 7,128 accessesView PDFCite