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Research ArticleOpen accessIn the keywordsInfluence of Intracellular Reactive Oxygen Species in Several Spermatozoa Activity in Indonesian Ongole Bull Cryopreserved SpermKurniawan Dwi Prihantoko, Asmarani Kusumawati, Mulyoto Pangestu et al.Certain factors may affect sperm motility and integrity in a freezing process. Reactive Oxygen Species (ROS) is essential in damaging the sperm, as the previous study revealed that ROS is a major cause damaging the membrane of spermatozoa. This study aimed to understand ROS production and its interaction within the motility, mitochondrial activity and DNA damage to the cryopreservation process … …American Journal of Animal and Veterinary Sciences, Vol. 17, Issue 1 · 26 Jan 2022 · 6,842 accessesView PDFCite
Research ArticleOpen accessIn the keywordsThe Investigation of Organelle Genomes of Extra Nuclear Sunflower Mutants with Variegated PhenotypeIrina Dremuk, Nikolay Kozel, Mariya Logacheva et al.The comparative analysis of complete chloroplast and mitochondrial DNA sequences of the original inbred line 3629 and three extra nuclear mutant lines variegated-1, variegated-15, variegated-17, obtained by the N-nitroso-N-methylurea induced mutagenesis, was done. The studied mutant lines were presented two different phenotypes with diverse chlorophyll content: Pale/green mutant line variegated-17 with 1.8% relative (to 3629 line) chlorophyll content in mutant … …American Journal of Biochemistry and Biotechnology, Vol. 13, Issue 4 · 24 Oct 2017 · 7,633 accessesView PDFCite
Research ArticleOpen accessIn the keywordsProtective Effect of Enicostemma littorale Blume Methanolic Extract on Gentamicin-Induced Nephrotoxicity in RatsNiraj Mukundray Bhatt, Kinjal Chauhan, Sharad Gupta et al.Problem statement: The Amino glycoside antibiotics cause drug induced nephrotoxicity at therapeutic doses and thus limits the use clinically. Oxidative stress is one of the main reasons for the development of nephrotoxicity. Approach: In light of this the aim of the present study was to investigate the role of mitochondrial as well as post-mitochondrial oxidative stress in the development of … …American Journal of Infectious Diseases, Vol. 7, Issue 4 · 30 Nov 2011 · 9,547 accessesView PDFCite
Research ArticleOpen accessIn the keywordsOxidation of Exogenous Lactate by Lactate Dehydrogenase C in the Midpiece of Rat Epididymal Sperm is Essential for Motility and Oxidative ActivityHideaki Yamashiro, Masaaki Toyomizu, Akane Kadowaki et al.Problem statement: To identify the metabolic reaction-glycolysis or oxidative phosphorylation that is mainly involved in the production of energy required for rat sperm mobilization. Approach: Epididymal sperm were collected from Wistar rats and extended in lactate-containing or lactate-free raffinose-modified Krebs-Ringer Bicarbonate solution (mKRB)-egg yolk medium supplemented with 0, 1, 2, or 3 mM 2-Deoxy-D-Glucose (2 DG) and 1, 2, or … …American Journal of Applied Sciences, Vol. 6, Issue 10 · 31 Oct 2009 · 6,901 accessesView PDFCite
Research ArticleOpen accessIn the keywordsUncommon Toxicologic Profile at Toxic Doses of CPI-613 (an Agent Selectively Alters Tumor Energy Metabolism) in Rats and Minipigs Reflects Novel MechanismClaudia Maturo, King C. Lee, Robert Rodriguez, Robert ShorrProblem statement: CPI-613 is a novel anticancer agent and the toxicological profile has not been assessed. Accordingly, the objective of these studies was to thoroughly evaluate the Toxicokinetic (TK) effects of CPI-613 in rats and to compare the toxicological profile of rats to minipigs to determine if there were differences between the two animal species. Approach: These studies involved assessments … …American Journal of Pharmacology and Toxicology, Vol. 5, Issue 4 · 13 Jun 2011 · 9,582 accessesView PDFCite
Review ArticleOpen accessIn the keywordsCoenzyme Q10 and its Effective SourcesHamideh Vaghari, Roholah Vaghari, Hoda Jafarizadeh-Malmiri, Aydin BerenjianCoenzyme Q10 (2,3-dimethoxy, 5-methyl, 6-decaprenyl benzoquinone, CoQ10) is naturally present in many organisms. It has key roles in several biochemical pathways. CoQ10, as an electron and proton carrier for energy coupling leads to Adenosine Triphosphate (ATP) formation. Furthermore, in medicine, the pharmacological use of CoQ10 has attracted more attention due to its benefits in treating cardiovascular and degenerative neurologic diseases. … …American Journal of Biochemistry and Biotechnology, Vol. 12, Issue 4 · 10 Oct 2016 · 9,278 accessesView PDFCite
Research ArticleOpen accessIn the keywordsComparative Physiological and Molecular Study of Some Sheep Breeds in Saudi ArabiaMohammad S. AL-Harbi, Hamed S. Alwagdany, Sayed A.M. AmerNaemi, Heri, Najdi and Sawakni sheep breeds inhabiting Kingdom of Saudi Arabia were studied on both physiological and molecular bases. Native polyacrylamide gel-electrophoreses for two enzymes Malate Dehydrogenase (Mdh) and Malic Enzyme (Me) recorded 5 isoenzyme loci from which 4 were polymorphic and 1 was monomorphic. Mdh showed three fractions, the first was recorded in Sawakni and Najdi breeds, the … …American Journal of Biochemistry and Biotechnology, Vol. 9, Issue 2 · 20 Jun 2013 · 8,388 accessesView PDFCite
Research ArticleOpen accessIn the abstractUltrastructural and Circadian Morphometric Characteristics of Rat Pinealocytes Under Physiological and Toxic ConditionsAnna I. Anurkina, David A. Areshidze, Maria A. Kozlova, Valery P. ChernikovCarbon tetrachloride (CCl₄) exhibits pronounced neurotoxic effects following acute or chronic exposure. Recent studies indicate that the pineal gland responds to CCl₄ intoxication by altering its secretory function, although detailed ultrastructural changes in pinealocytes remain inadequately investigated. This research addresses the urgent need to elucidate the mechanisms of CCl₄ toxicity on the pineal gland, which could contribute to developing strategies … …OnLine Journal of Biological Sciences, Vol. 26, Issue 2 · 1 Jun 2026 · 1,170 accessesView PDFCite
Research ArticleOpen accessIn the abstractCytotoxicity Evaluation of Curcumin-FITC Conjugates in Granulosa Cells Isolated from Ovarian Follicles of Kampung Chicken (Gallus gallus domesticus)Sukarman Hadi Jaya Putra, Mansur S, UmarudinLinking curcumin to fluorescein isothiocyanate (FITC) results in a hybrid fluorescent marker (curcumin-FITC) that exhibits improved stability and sensitivity in detection. This study sought to evaluate the biological safety and cytotoxic effects of curcumin-FITC on granulosa cells obtained from ovarian follicles (2-5 mm, F1-F4 stage) of Kampung chickens. Following fluorescent labeling with different concentrations of curcumin-FITC (0-100 μg/mL), cell viability … …OnLine Journal of Biological Sciences, Vol. 26, Issue 2 · 14 May 2026 · 1,497 accessesView PDFCite
EditorialOpen accessIn the abstractGLUTATHIONE: A POSSIBLE LINK TO AUTOPHAGY IN SYSTEMIC LUPUS ERYTHEMATOSUSDilip Shah, Swapan K. NathIncreased free radical formation and altered redox state are of fundamental importance in the pathogenesis of autoimmune diseases including Systemic Lupus Erythematos (SLE). Free radicals are mainly derived from oxygen (Reactive Oxygen Species/ROS) and nitrogen (Reactive Nitrogen Species/RNS) at mitochondria, cellular membranes and the endoplasmic reticulum membrane as physiological responses to a variety of internal and external stress (Shah et … …American Journal of Immunology, Vol. 10, Issue 3 · 3 Sep 2014 · 12,773 accessesView PDFCite