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50 articles for “Trial Design”
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Research ArticleOpen accessIn the abstractClinical Signs of Hairballs in Cats Fed a Diet Enriched with CelluloseA. C. Beynen, J. Middelkoop, D. H.J. SarisProblem statement: The intake of cellulose may delay gastric emptying and raise the intestinal transit rate. These effects could antagonize hairball formation. Thus, it was hypothesized that a diet enriched with a cellulose preparation (Arbocel BWW40®), forming a completely insoluble fiber network, would diminish the severity of clinical symptoms of hairballs in cats. Approach: In a double-blind, placebo-controlled trial with … …American Journal of Animal and Veterinary Sciences, Vol. 6, Issue 2 · 8 Aug 2011 · 11,925 accessesView PDFCite
Research ArticleOpen accessIn the abstractDesign and Manufacturing of a Custom Skull ImplantJuan Felipe Isaza Saldarriaga, Santiago Correa Vélez, M.D. Adolfo Cumplido Posada et al.Problem statement: Cranioplasty is defined as a neurosurgical procedure to cover an injured bone in the skull. This procedure is carried out in order to protect and restore intracranial structures and to restore the appearance and psychological stability of the patient. Advances in medical imaging, such as MRI and CT, have allowed the 3D reconstruction of anatomical structures for several … …American Journal of Engineering and Applied Sciences, Vol. 4, Issue 1 · 17 Mar 2011 · 9,571 accessesView PDFCite
Research ArticleOpen accessIn the abstractModeling Heterogeneity in Phase II Clinical TrialsChristopher N. Barnes, Shesh N. RaiProblem statement: The common assumption in non-randomized Phase II clinical trials is a homogeneous population with homogeneous response. This assumption is at odds with many trials today; a heterogeneous response due to the existence of subgroups. Approach: In order to examine the effects of heterogeneity on the trial outcome, a systematic platform is developed to quantify the range and classes … …Current Research in Biostatistics, Vol. 1, Issue 1 · 30 Jun 2010 · 10,131 accessesView PDFCite
Research ArticleOpen accessIn the abstractDesign Based on Intra-Class Correlation CoefficientsRobert Lew, Gheorghe DorosProblem statement: Reliability studies are concerned with the study of "consistency" or "repeatability" of measurements. Often times (but not always) the reliability coefficients are Intra-class Correlation Coefficients (ICC). Depending on the design or the conceptual intent of the study there are three types of intra-class correlation coefficients, termed intra-class correlation coefficients Case 1, 2 and 3, for measuring the reliability … …Current Research in Biostatistics, Vol. 1, Issue 1 · 30 Jun 2010 · 18,550 accessesView PDFCite
Research ArticleOpen accessIn the abstractDesign and Evaluation of Three Pair Primers for Exon 1 Amplification of Hyaluroglucosaminidase-1 GeneUsman Sumo Friend Tambunan, Sylvia Sugito, Arli Aditya ParikesitProblem statement: Hyaluronidase is an enzyme which catalyze hydrolysis of Hyaluronan (HA). Hyaluronan is important in cell migration during embryonic development, cellular proliferation and differentiation and has a structural role in connective tissues. Hyaluronidase deficiency is correlated with mucopolysaccharidosis IX. In human, hyaluronidase is encoded by HYAL1 gene. The mutation study of HYAL1 gene was carried out by many researchers, … …OnLine Journal of Biological Sciences, Vol. 10, Issue 2 · 16 Jun 2010 · 8,711 accessesView PDFCite
Research ArticleOpen accessIn the abstractSimulation of Airflow and Aerodynamic Forces Acting on a Rotating Turbine VentilatorA.S. Farahani, N.M. Adam, M.K.A. AriffinProblem statement: Rotating turbine ventilators were generally found in most countries. They were simple in structure, light in weight and cheap to install. It was quite surprising that, the aerodynamics of this common device had not been numerically examined and the design process of most of these ventilators had developed progressively through trial and error methods. Approach: This study was … …American Journal of Engineering and Applied Sciences, Vol. 3, Issue 1 · 31 Mar 2010 · 8,719 accessesView PDFCite
Research ArticleOpen accessIn the abstractDesign Analysis of High-Speed Axial-Flux GeneratorM. Sadeghierad, A. Darabi, H. Lesani, H. MonsefProblem Statement: Axial flux permanent magnet machines are regarded as compact high efficiency generators for micro-turbines employed in the distributed power generation systems. High-speed rotor of the generator causes some designing and modeling problems. Sensitivity analysis tasks of the machine parameters are difficult and completely different in comparison with the problems associated with conventional machines. Approach: This article presents a … …American Journal of Engineering and Applied Sciences, Vol. 1, Issue 4 · 31 Dec 2008 · 7,569 accessesView PDFCite
Research ArticleOpen accessIn the abstractEnhancing P300 Component by Spectral Power Ratio Principal Components for a Single Trial Brain-Computer InterfaceS. Andrews, Ramaswamy Palaniappan, Andrew Teoh, Loo chu KiongHere we present a novel approach to detect P300 wave in single trial Visual Event Related Potential (VERP) signals using improved principal component analysis to enable a faster brain-computer interface (BCI) design. In the process, the principal components (PCs) are selected using novel methods, namely spectral power ratio (SPR) and sandwich spectral power ratio (SSPR). We set out to assess … …American Journal of Applied Sciences, Vol. 5, Issue 6 · 30 Jun 2008 · 7,884 accessesView PDFCite
Research ArticleOpen accessIn the abstractDecentralized Controller Design for Static Synchronous Compensator Using Robust Quantitative Feedback Theory MethodSeyed Abbas Taher, Reza Hematti, Ali Abdolalipour, Majid NematiThe Static Synchronous Compensator (STATCOM) provides shunt compensation in similar way to the Static VAR Compensator (SVC) but utilizes a voltage source converter rather than capacitors and reactor. In practice systems use simple Proportional-Integral (PI) controllers for control of STATCOM. However, since the PI control parameters were usually tuned based on classical or trial-and-error approaches, they were incapable of obtaining … …American Journal of Engineering and Applied Sciences, Vol. 1, Issue 1 · 31 Mar 2008 · 7,461 accessesView PDFCite
Research ArticleOpen accessIn the abstractClosed Die Forging Geometrical Parameters Optimization for Al-MMCM. Jolgaf, S.B. Sulaiman, M.K.A Ariffin, A.A. FaiezaDemand for lighter and stiffer products has been increasing in the last few years especially in automobile manufacturing. The closed die forging process of Metal Matrix Material (MMC) is presented as possible solution, since it produces parts with good mechanical properties and lighter weight. A computational modeling of closed die forging process using finite element method and optimization techniques makes … …American Journal of Engineering and Applied Sciences, Vol. 1, Issue 1 · 31 Mar 2008 · 8,482 accessesView PDFCite