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Research ArticleOpen accessIn the keywordsRegulation of Gene Expression by β-GlucansMary O. Huff, Carolyn M. Klingeβ-D-glucans are diverse polysaccharides derived from plant cell walls, fungi and bacteria. β-D-glucans are composed of D-glucose monomers linked by (1-3) β-glycosidic bonds with varying amounts of (1-6) or (1-4) linked side chains that bind cell surface receptors ultimately triggering changes in intracellular pathways and gene transcription. β-D-glucans have anti-viral, immunomodulatory and anti-cancer activities. This article reviews the current identity … …American Journal of Immunology, Vol. 13, Issue 1 · 12 Apr 2017 · 7,557 accessesView PDFCite
Research ArticleOpen accessIn the keywordsDetecting Patterns in 5’ Untranslated Regions of Genes Involved in the Regulation of Blood Pressure and Oxidative StressMaria Sanchez-Aguilar, Luz Ibarra-Lara, Beatriz Zamora-Lopez et al.Hypertension is a chronic physical condition with multifactorial causes. Although genetic factors have been associated to this pathological condition, characterization of the sequence patterns in the regulatory sites, for example, in 3’ or 5’ Untranslated Regions (UTR), remains to be explored. In particular, the 5’ UTR of genes associated with the regulation of blood pressure and oxidative stress are analyzed … …Current Research in Medicine, Vol. 4, Issue 2 · 27 Nov 2013 · 7,285 accessesView PDFCite
Research ArticleOpen accessIn the keywordsInfluence of Heirloom Tomato Polyphenol Extracts on Expression of Inflammation Genes in BovineKwaku Gyenai, Nona Mikiashvili, Hamid Ismail, Mulumebet WorkuThe effect of tomato on diseases of economic importance continues to be of broad interest. To evaluate these relationships, the effect of crude extracts of Cherokee purple tomato on pro-inflammatory genes and cytokines were evaluated. Neutrophils from three Holstein Fresian cows were treated with Phosphate Buffered Saline (PBS) or E. coli O111-B4 Lipopolysaccharide (LPS). Treated cells were exposed to different … …American Journal of Animal and Veterinary Sciences, Vol. 7, Issue 3 · 25 Aug 2012 · 8,380 accessesView PDFCite
Research ArticleOpen accessIn the keywordsA Sequence Based Validation of Gene Expression Microarray DataGerhard G. Thallinger, Eva Obermayr, Pornpimol Charoentong et al.Problem statement: Quantitative Reverse Transcription PCR (RT-qPCR) is often used to validate microarray data. Previous studies show different levels of correlation, without further investigation of influencing factors. Approach: We compared expression levels of 381 genes obtained from microarray hybridizations and from TaqMan based RT-qPCR assays. Correlation of expression levels was determined by comparing: (i) single genes across samples, (ii) all … …Current Research in Bioinformatics, Vol. 1, Issue 1 · 19 Jan 2012 · 13,722 accessesView PDFCite
Research ArticleOpen accessIn the keywordsRole of Cardioprotective Diet in Acute Coronary SyndromeR. B. Singh, Suniti Dharwadkar, Fabien DeMeester et al.Problem statement: Nutritional factors appear to be quite important in the pathogenesis and prognosis among patients of Acute Myocardial Infarction (AMI) or Acute Coronary Syndrome (ACS). Increased consumption of proinflammatory foods; such as refined starches and sugar, trans fat, saturated fat and w-6 fatty acids may increase proinflammatory cytokines, oxidative stress and free fatty acids causing endothelial dysfunction. Approach: Columbus … …Current Research in Medicine, Vol. 2, Issue 2 · 15 Oct 2011 · 7,463 accessesView PDFCite
Research ArticleOpen accessIn the keywordsDetection and Localization of Anti and Pro-apoptotic mRNA Genes in Human Colorectal Cancer Using in situ RT-PCRMohd. Nazil Salleh, Boo Siaw Shi, Wan Khairuzzaman Wan Ramli et al.Problem statement: Recent studies using conventional Polymerase Chain Reaction have shown that anti-apoptotic (Cyclooxygenase-2, COX-2 and Nuclear Factor-κB, NF-κB) and proapoptotic mRNA (Bax and Bad) are involved in the tumorigenesis of colorectal cancer. The aim of this study was to localize the expression of anti and pro-apoptotic mRNA genes using Reverse Transcription in situ Polymerase Chain Reaction (RT in situ … …American Journal of Biochemistry and Biotechnology, Vol. 6, Issue 3 · 30 Sep 2010 · 7,446 accessesView PDFCite
Research ArticleOpen accessIn the keywordsNutritional control of HIV-AIDS-A case for SeleniumParisa Kalantari, Hema Vunta, Umamaheswari D. Palempalli et al.Selenium (Se) is a micronutrient that is incorporated into proteins. Some of the selenoenzymes such as GPXs and thioredoxin reductases exhibit glutathione peroxidase-dependent activities towards organic and inorganic peroxides. Thus, selenoenzymes play a pivotal role in mitigating oxidative stress caused by accumulation of peroxides. In this respect, selenoproteins may interfere with the transcription-driven by oxidative stress-dependent signaling mechanisms to influence … …American Journal of Infectious Diseases, Vol. 3, Issue 4 · 31 Dec 2007 · 7,346 accessesView PDFCite
Research ArticleOpen accessIn the keywordsGenetic and Biochemical Aspects of Ectoine Biosynthesis in Moderately Halophilic and Halotolerant Methylotrophic BacteriaValentina N. Khmelenina, Ildar I. Mustakhimov, Alexander S. Reshetnikov et al.Problem statement: The cyclic imino acid ectoine is a widely distributed compatible solute synthesizing by halophilic and halotolerant bacteria to prevent osmotic stress at high external salinity. This water-keeping compound is used in a variety of commercial cosmetics and therapeutic products. Approach: Development of integrated, predictive functional model of the metabolic and regulatory netwoks of ectoine-producing microbes is an active … …American Journal of Agricultural and Biological Sciences, Vol. 5, Issue 4 · 13 Dec 2010 · 9,565 accessesView PDFCite
Review ArticleOpen accessIn the keywordsMitochondria are Naturally Micro Robots - A reviewRaffaella Aversa, Relly Victoria V. Petrescu, Antonio Apicella, Florian Ion T. PetrescuThe mitochondrion is a natural robot (cell) with a length of about one micron. Between organisms (plant, animal or human) with its organs and the atomic and molecular components are positioned based cells, which are building all the necessary organs body. Years ago, medical specialists who are studying organ disease have considered that is caused by impaired organ or related … …American Journal of Engineering and Applied Sciences, Vol. 9, Issue 4 · 18 Nov 2016 · 8,838 accessesView PDFCite
Research ArticleOpen accessIn the keywordsCocaine: A Catalyst for Human Immunodeficiency Virus-Associated DementiaNavneet K. Dhillon, Milind Gadgil, Andy Rahardja et al.Injection drug use has been recognized as a major risk factor for AIDS from the outset of the epidemic. Cocaine, one of the most widely abused drugs in the United States can both impair the functions of macrophages and CD4+ lymphocytes and also activate HIV-1 expression in these cells. Cocaine is a multifactorial agent that acts globally to impair the … …American Journal of Infectious Diseases, Vol. 4, Issue 2 · 30 Jun 2008 · 7,590 accessesView PDFCite