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185 results for “Receptor”
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Research ArticleOpen accessEvery word in the titleRetinoids Chemosensitize Ovarian Cancer Cell Lines to Cisplatin Independent of Nuclear Receptors and p53Suresh Guruswamy, Doris M. BenbrookTreatment of ovarian cancer with cisplatin-based chemotherapy is highly toxic and is often followed by cancer recurrence. Repeated treatments with cisplatin frequently result in the development of resistance to this drug. Drugs with low toxicity that could enhance the tumor cell killing effects of cisplatin could potentially reduce the toxicity and enhance the efficacy of cisplatin. The mechanism of cell … …American Journal of Pharmacology and Toxicology, Vol. 1, Issue 4 · 31 Dec 2006 · 6,958 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleExpression, Purification and Activity Assay of Two New Recombinant Antagonists of Fibrinogen ReceptorJianbo Yang, Jia Yao, Kun Yang et al.The gene sequence of Decorsin which is extracted from a kind of North American leeches was synthesized. Two recombinant proteins, Annexin V plus Decorsin (AnnV-D39) and Annexin V plus the carboxyl terminal 27 amino acid residues of Decorsin(AnnV-D27), were constructed. And a 10 amino acids linker peptide of GGGGSGGGGS was inserted between Annexin V and Decorsin in AnnV-D39. Using pET-28(a+) … …American Journal of Biochemistry and Biotechnology, Vol. 1, Issue 2 · 30 Jun 2005 · 6,913 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleAndrogen Receptor in Macrophages of Male Rat is Greater Than in FemaleKazem Ahmadi, Alan B. McCrudenThe presence and possible sex differences of androgen receptor in peritoneal macrophages was investigated using immunomagnetic beads. Macrophages were incubated with different concentrations of [3H]-5αDHT in the presence or absence of a 100 fold excess of unlabelled 5α-DHT. Labelled cells were separated from unbound steroid by immunomagnetic beads coated with anti-rat macrophage antibody. The binding identified in the rat macrophages … …American Journal of Immunology, Vol. 1, Issue 1 · 31 Mar 2005 · 6,830 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleExpression of Adiponectin Receptors in Human Placenta and Its Possible Implication in Gestational DiabetesNaglaa Fathy Al Husseini, Mosaad M. Odaa, M.A. Mohamed et al.Problem statement: Similar to obese patients and type 2 diabetic patients, adiponectin levels are reduced in former Gestational Diabetes Mellitus (GDM) patients and are lower in GDM women during late pregnancy compared with pregnant control subjects matched for BMI. Diabetic insult at later stages in gestation, such as may occur in gestational diabetes, will foremost lead to short-term changes in … …American Journal of Biochemistry and Biotechnology, Vol. 6, Issue 2 · 30 Jun 2010 · 8,193 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleToll-Like Receptor (TLR) 2 and TLR4 Gene Expression in Canine HeartA. Linde, F. Blecha, T. MelgarejoToll-like receptors (TLRs) are archetypal pattern recognition receptors of immediate importance for an efficacious innate immune response. TLRs exhibit marked differential tissue activity and their levels within a discrete cell type can be highly dynamic. Of 13 known mammalian paralogues, three TLRs have been identified in the dog. Although cardiac TLR expression has been reported in other species, this study … …American Journal of Animal and Veterinary Sciences, Vol. 2, Issue 1 · 31 Mar 2007 · 6,921 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleIgG Subclass Variation of a Monoclonal Antibody Binding to Human Fc-Gamma ReceptorsRekha Patel, Krista K. Johnson, Bruce A. Andrien, Paul P. TamburiniThe importance of human Fc receptors in immune regulation is well known. Their role is critical not only in the recruitment of cellular effector functions but also in regulating the balance in the periphery between autoimmunity and tolerance. Despite their central importance, there is a dearth of literature on controlled numeric comparisons in affinities of antibody subclasses for gamma receptors. … …American Journal of Biochemistry and Biotechnology, Vol. 9, Issue 3 · 21 Sep 2013 · 8,065 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleTargeting Cellular Receptors as a Strategy for the Development of New Generation Mucosal VaccinesConstantine Bitsaktsis, Kari Wiedinger, Edmund Joseph GosselinMucosal pathogens are a primary source of infection that require the development of vaccines to induce a specific, protective and long lasting immune response. Despite an urgent need, development of effective mucosal immunization strategies has proven difficult. The literature was reviewed to elucidate cell specific targets that may be utilized to increase the immunogenicity of protective antigens through mucosal vaccination. … …American Journal of Immunology, Vol. 9, Issue 1 · 2 Feb 2013 · 7,026 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleThe Innate Immunity in Bovine Mastitis: The Role of Pattern-Recognition ReceptorsFernando Nogueira de Souza, Eduardo Milton Ramos Sanchez, Marcos Bryan Heinemann et al.Mastitis is the most costly disease for dairy farmers and industry, which are mainly caused by the entry of bacteria to the teat canal. Shortly after the entry of the invading bacteria, the innate immunity recognizes the invading pathogen through pattern recognition receptors and initiates the inflammatory response necessary to eliminate the invading bacteria. This initial inflammatory response releases cytokines … …American Journal of Immunology, Vol. 8, Issue 4 · 18 Oct 2012 · 10,352 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleInvolvement of Microsomal Na+/K+ ATPase Activity in the Mechanism of Action of Dopaminergic D2 ReceptorsAbdulrahim Abu-JayyabProblem statement: Our previous research has shown that mitochondrial ATPase may have a role in the action of dopaminergic D2 receptors. It is therefore, thought of interest to investigate the effect of bromocriptine, sulpiride or their combination on the mitochondrial and microsomal ouabain sensitive and ouabain insensitive Na+/K+-ATPase in the liver of rats. Approach: In vivo treatment was carried out … …American Journal of Pharmacology and Toxicology, Vol. 4, Issue 4 · 31 Dec 2009 · 6,971 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleCD2 Shown to Facilitate CD4+ Cell Differentiation during Visceral Leishmaniasis, a Receptor Based StudySukrat Sinha, Shanthy Sundaram, Sanjiva Bimal et al.This study addressed the role of CD2 on CD4+ T helper cells in relation to the TCRVα1 and CD70 in two groups of BALB/c mice viz control and infected (1×107 L. donovani promastigotes). The results showed with the downregulation of CD2 expression there is a pronounced decrease of TCRVα1 and CD70 on CD4+ cells in mice. An insight into the … …American Journal of Biochemistry and Biotechnology, Vol. 11, Issue 4 · 28 Nov 2015 · 7,828 accessesView PDFCite