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39 articles for “Rat Model”
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Research ArticleOpen accessIn the abstractEffects of Hyperoxia on Brain Tissue Oxygen Tension in Non-Sedated, Non- Anesthetized Arctic Ground Squirrels: An Animal Model of Hyperoxic StressYilong Ma, Shufen Wu, Lawrence DuffyArctic Ground Squirrels (AGS) are classic hibernators known for their tolerance to hypoxia. AGS have been studied as a model of hypoxia with potential as a medical research model. Problem statement: Their unique resistance to the stressors of low oxygen led us to hypothesize that AGS might also be adaptable to hyperoxia. Approach: This study examined the physiological pattern associated … …American Journal of Animal and Veterinary Sciences, Vol. 6, Issue 1 · 26 Apr 2011 · 8,476 accessesView PDFCite
Research ArticleOpen accessIn the abstractMeasure for No Three-Factor Interaction Model in Three-Way Contingency TablesKouji Yamamoto, Kyoji Hori, Sadao TomizawaProblem statement: For 2×2×K contingency tables, the measure is considered to represent the degree of departure from a log-linear model of No Three-Factor Interaction (NOTFI). We are interested in considering a similar measure for general I×J×K contingency tables. Approach: The present study proposed a measure to represent the degree of departure from the NOTFI model for I×J×K contingency tables. Also … …Current Research in Biostatistics, Vol. 1, Issue 1 · 30 Jun 2010 · 7,786 accessesView PDFCite
Research ArticleOpen accessIn the abstractHypolipidemic Effects of Coenzyme Q10 in Experimentally Induced Hypercholesterolemic Model in Female RatsAtef M. Al-AttarProblem statement: Hyperlipidemia is well known to play a main role in the development of atherosclerosis. It is characterized by abnormally elevated cholesterol, triglyceride, low density lipoprotein cholesterol and very low density lipoprotein cholesterol levels in the blood. It has been recognized for many years that hypercholesterolemia is a major risk factor for cardiovascular diseases such as atherosclerosis, myocardial infraction, … …American Journal of Pharmacology and Toxicology, Vol. 5, Issue 1 · 31 Mar 2010 · 45,651 accessesView PDFCite
Research ArticleOpen accessIn the abstractEffects of Bacillus subtilis 'PB6' (ATCC - PTA 6737) on Clostridium difficile Associated Diarrhea (CDAD) and Inflammatory Bowel Disease (IBD) in Animal ModelsEric Peys, Jerry Varghese, Ponusami Suresh et al.The administration of probiotic bacteria is emerging as a potential means of preventing the onset or recurrence of Clostridium difficile associated diarrhea (CDAD) and of attenuating inflammatory activity and preventing relapses in inflammatory bowel disease (IBD). We evaluated the efficacy of Bacillus subtilis 'PB6' (ATCC - PTA 6737) in a hamster model of antibiotic-induced CDAD and in a rat model … …American Journal of Infectious Diseases, Vol. 3, Issue 4 · 31 Dec 2007 · 7,102 accessesView PDFCite
Research ArticleOpen accessIn the abstractCPI-1189 Protects against TNBS-induced Colitis in a Rodent ModelBeverley Greenwood-Van Meerveld, Karl TylerNitrone-related therapeutics (NRTs) represents a new class of molecules that may be effective in treating inflammatory conditions. The goal of this study was to examine the effect of CPI-1189 in a rat model of inflammatory bowel disease (IBD). Colonic inflammation was induced by an enema of trinitrobenzene sulfonic acid (TNBS). Saline-enema treated rats served as controls. After 3 days colonic … …American Journal of Pharmacology and Toxicology, Vol. 2, Issue 2 · 30 Jun 2007 · 7,176 accessesView PDFCite
Research ArticleOpen accessIn the abstractSitagliptin Impairs Healing of Experimentally Induced Gastric Ulcers Via inhibition of iNOS and COX-2 ExpressionAmina Unis, Eman AbdelzaherGastric ulcer healing is a complex process that is regulated by several promoting factors including COX-2 and iNOS. Diabetes mellitus is usually associated with delayed gastric ulcer healing. Hence, the current study was designed to investigate the effect of sitagliptin (dipeptidyl peptidase-4 inhibitor) on gastric ulcer healing and expression of iNOS and COX-2 in rat stomach.The study was conducted on … …American Journal of Pharmacology and Toxicology, Vol. 8, Issue 3 · 4 Sep 2013 · 7,440 accessesView PDFCite
Research ArticleOpen accessIn the abstractInfluence of Helium-Neon Laser Photostimulation on Excision Wound Healing in Wistar RatsB. S. Nayak, A. Maiya, P. KumarThe importance of laser photostimulation is now accepted generally but the laser light facilitates wound healing and tissue repair remains poorly understood. So we have examined the hypothesis that the laser photo stimulation can enhances the collagen production in excision wounds using excision wound model in Wister rat model. The circular wounds were created on the dorsum of the back … …OnLine Journal of Biological Sciences, Vol. 7, Issue 2 · 31 Dec 2007 · 7,379 accessesView PDFCite
Research ArticleOpen accessIn the abstractEffect of Chromium(VI) on Serum Iron and Removal of its Toxicity by Combining Deferasirox and Deferiprone Chelators in RatsS. Jamil A. Fatemi, Marzieh Iranmanesh, Faezeh Dahooee BaloochThe present research is aimed to characterize the potential efficiency of two chelators after chromium(VI) administration for 60 days following two doses of 15 and 30 mg kg-1 chromium(VI) per body weight daily to male rats. However, the hypothesis that the two chelators might be more efficient as combined therapy than as single therapy in removing chromium(VI) from bood serum … …American Journal of Pharmacology and Toxicology, Vol. 8, Issue 4 · 30 Oct 2013 · 7,156 accessesView PDFCite
Research ArticleOpen accessIn the abstractγAminobutyrate B Receptors in Central Amygdaloid and Medial Amygdaloid Nuclei of Amygdala Modulate Aggression in Male RatsMahnaz Taherianfard, Zahed Abdolahi, Hamid Rajaian et al.One neurochemical system most consistently linked with aggression is the GABAergic system. The aim of the present investigation was to examine the effect of injection of baclofen (GABAB agonist) and CGP35348 (GABAB antagonist) in the Central Amygdaloid (CA) and Medial Amygdaloid (MA) nuclei of the amygdala on offensive aggression behavior in the animal model. Sixty six adult male rats weighing … …Neuroscience International, Vol. 3, Issue 1 · 3 Sep 2012 · 7,261 accessesView PDFCite
Research ArticleOpen accessIn the abstractAnti-Microbial, Anti-Oxidant and Anti-Ulcerogenic Effects of Shilajit on Gastric Ulcer in RatsMohamed-I. Kotb El-Sayed, Hatem-K. Amin, Ali-G. Al-KafProblem statement: To evaluate the effects and mechanisms of action involved in anti-ulcer, antioxidant and antimicrobial activities of different native shilajit samples. Approach: Shilajit samples were collected in the mountain region of Yemen (Al-Jouf and Rayma), Russia (Tien-Shan) and India (Kumoan). Stomach ulcers were induced in rats by oro-gastric ingestion of ethanol/HCl. Pre-treatment with ranitidine (100 mg kg-1, p.o.) and … …American Journal of Biochemistry and Biotechnology, Vol. 8, Issue 1 · 10 Mar 2012 · 9,002 accessesView PDFCite