23 articles for “Melanoma”

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Research ArticleOpen accessIn the abstractAnticancer Activities of Some New Synthesized Thiazolo[3,2-a]Pyrido[4,3-d]Pyrimidine DerivativesAshraf M. Mohamed, Abdel-Galil E. Amr, Musaed A. Alsharari et al.Problem statement: This study describes the synthesis and anticancer activities of a new series of thiazolo[3,2-a]pyrimidines derivatives (2-7) using 3,5-bisarylmethylene-1-methyl-4- piperidone and 4-aryl-8-arylmethelene-6-methylpyrido[4,3-d]pyrimidine-2(1H)thiones as a starting materials. Approach: The antitumor activities of the newly synthesized compounds 4-7 were evaluated utilizing 60 different human tumor cell lines, representing leukemia, melanoma, lung, colon, brain, ovary, breast and prostate as well as kidney. … …American Journal of Biochemistry and Biotechnology, Vol. 7, Issue 2 · 23 Aug 2011 · 10,093 accessesView PDF Cite

Research ArticleOpen accessIn the abstractAn Efficient Production of Oligosaccharides by a Reaction using Whole Mammalian Cells as BiocatalystsTomohisa Kato, Rie Mitsumori, Kenichi HatanakaProblem statement: Mammalian cells were used for the production of oligosaccharides by saccharide primer method. However, because cells in culture are used, productivity of oligosaccharides is low. Approach: In saccharide primer method employing cells under culture, glycosylation was performed only by mixing the collected cells in reaction mixtures. Saccharide primer, 12-azidododecyl β-lactoside that mimics lactosylceramide (LacCer), was incubated with various … …American Journal of Biochemistry and Biotechnology, Vol. 4, Issue 4 · 31 Dec 2008 · 6,441 accessesView PDF Cite

Research ArticleOpen accessIn the abstractInhibition of Sphingolipid Biosynthesis in Cultured Cells Enhances the Oligosaccharide Production from Exogenous Artifical SubstrateTomohisa Kato, Maria Carmelita Z. Kasuya, Kenichi HatanakaThe effect of fumonisin B1 which is an inhibitor of ceramide synthesis on saccharide elongation of dodecyl β-lactoside (Lac-C12), which is the analogue of lactosyl ceramide (LacCer), in mouse melanoma B16 cells and African green-monkey kidney (Vero) cells was examined. By adding fumonisin B1 in the culture medium used for glycosylation of Lac-C12, mouse melanoma B16 cells synthesized GM3-type analogue … …American Journal of Biochemistry and Biotechnology, Vol. 4, Issue 3 · 30 Sep 2008 · 6,671 accessesView PDF Cite