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36 results for “Liver Toxicity”
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Research ArticleOpen accessIn the abstractEffect of Green Tea on Hepatic Cells Under the Influence of Inflammatory Conditions: In Vitro StudyIbrahim G. Saleh, Zulfiqar Ali, Farid M. Hamada et al.The concern about safety of consumption of Green Tea (GT) supplements has become a scope of many studies. We and others have described earlier the effect of the administration of GT and its polyphenols on liver in a mouse model. In this study we aimed to investigate the effect of GT on HepG2 cells. HepG2 cells were treated with different … …American Journal of Pharmacology and Toxicology, Vol. 8, Issue 4 · 3 Dec 2013 · 7,314 accessesView PDFCite
Research ArticleOpen accessIn the abstractCombined Chelation Therapy with Deferasirox and Desferrioxamine In Removing Lead from RatsFaezeh Dahooee Balooch, Seyed Jamilaldin Fatemi, Marzieh Iranmanesh, Batool HosseinkhaniThe present study aimed to evaluate the potential efficiency of Deferasirox (DFX) and Desfferioxamine (DFO) as chelating agents in removing lead from rats as a biological model. Two different doses of lead (II) chloride (40 and 80 mg kg-1 body weight) were used for 45 days. After this period, all rats showed toxicity symptoms through loss of hair, greenish mottling … …American Journal of Pharmacology and Toxicology, Vol. 8, Issue 4 · 24 Sep 2013 · 7,151 accessesView PDFCite
Research ArticleOpen accessIn the abstractEvaluation of Antimalaria Activity and Acute Toxicity of Xetospongia spSyamsudin Abdillah, Rahmatul Wahida Ahmad, Yatnita Parama Cita, Noriah Mohd NoorWe investigated the in vivo activity of extract of Xetospongia sp against Plasmodium berghei Strain ANKA and acute toxicity in mice. The ethanolic extracts of the Xetospongia sp (50-400 mg kg-1 day) were screened for blood schizonticidal against P. berghei strain ANKA in mice during early and established infections. Acute toxicity of extracts of Xetospongia sp at the dose 5000 … …American Journal of Pharmacology and Toxicology, Vol. 8, Issue 2 · 2 Sep 2013 · 7,796 accessesView PDFCite
Research ArticleOpen accessIn the abstractNevirapine Hepatotoxicity: Implications of Risk FactorsElias Adikwu, Oputiri Deo, Oru-Bo Precious Geoffrey, D. Akuegbe EnimeyaHighly active antiretroviral therapy is used in the management of HIV/AIDS; it has contributed tremendously in the reduction of mortality and morbidity rate in HIV patients. Despite the outstanding achievement with the use of HAART its major limitation is toxicity. Among these toxicities is hepatotoxicity which is said to be associated with nevirapine containing highly active antiretroviral therapy. Recent reports … …American Journal of Pharmacology and Toxicology, Vol. 8, Issue 2 · 3 Jun 2013 · 7,653 accessesView PDFCite
Research ArticleOpen accessIn the abstractPossible Mechanism of Plumbago zeylanica in Prevention of Hepatic Dammage in Wistar RatRohit Goyal, Pyare Lal SharmaPlumbago zeylanica root has been used traditionally to treat various body ailments including liver diseases. The present study was designed to investigate the hepatoprotective effects of standardized methanolic extract of Plumbago zeylanica root on paracetamol, CCl4 and alcohol induced hepatic injuries in rats and its possible mechanism(s) of hepatoprotection. Administration of hepatotoxicants like paracetamol (3 g kg-1, p.o.) or CCl4 … …American Journal of Pharmacology and Toxicology, Vol. 7, Issue 3 · 20 Nov 2012 · 7,638 accessesView PDFCite
Research ArticleOpen accessIn the abstractToxicological Evaluation of Murraya Paniculata (L.) Leaves Extract on RodentsR. K. Goel, C. V. Rao, A. Singh, M. K. GautamProblem statement: Present study was aimed to explore the acute and sub-acute toxicities studies with orally administered 50% ethanolic leaves extract of Murraya paniculata. Approach: Acute toxicity (oral single dose, 50-2000 mg kg-1) includes any mortality and CNS and ANS toxicities in mice while, sub-acute toxicity (100, 200 and 400 mg kg-1, orally and once daily for 28 days) includes … …American Journal of Pharmacology and Toxicology, Vol. 7, Issue 2 · 9 Jul 2012 · 8,076 accessesView PDFCite
Research ArticleOpen accessIn the abstractEffect of Storing Temperature on Hepatotoxicity and Nephrotoxicity of Ifosfamide in Female RatFalah Mohammed AzizProblem statement: Ifosfamide (IFO) is a cytotoxic alkylating drug used for the treatment of a variety of cancers, although it has been found to induce certain hematological, hepatotoxic and nephrotoxic side effects. This drug is widely used in developing country, especially Iraq, but without caring too much to the storing temperature due to low drug maintaining facilities. The present work … …OnLine Journal of Biological Sciences, Vol. 12, Issue 1 · 19 Mar 2012 · 7,883 accessesView PDFCite
Research ArticleOpen accessIn the abstractAcute and Sub-acute Toxicity of Crataegus Aronia Syn. Azarolus (L.) Whole Plant Aqueous Extract in Wistar RatsAbdullah S. ShatoorProblem statement: Hawthorn comprises more than 200 species worldwide but very few species have been used medicinally. In Mediterranean region, the predominant species of the genus Crataegus is C. aronia syn. Azarolus (L). The extracts or tinctures prepared from the leaves, flowers and/or a fruit has been used traditionally for the treatment of different diseases including different cardiovascular problems. This … …American Journal of Pharmacology and Toxicology, Vol. 6, Issue 2 · 17 Aug 2011 · 14,660 accessesView PDFCite
Research ArticleOpen accessIn the abstractS-Allyl-Cysteines Reduce Amelioration of Aluminum Induced Toxicity in RatsSadhana ShrivastavaProblem statement: Aluminum (Al) is a trivalent cation found in its ionic form in most kinds of animal tissues and in natural waters everywhere. Approach: It is a potent neurotoxin and has been associated in the pathogenesis of several clinical disorders including Alzheimer’s disease. Results: The aim of the study was to demonstrate the protective effect of S-Allyl-Cysteines (SAC) against … …American Journal of Biochemistry and Biotechnology, Vol. 7, Issue 2 · 12 Aug 2011 · 7,748 accessesView PDFCite
Research ArticleOpen accessIn the abstractToxicity evaluation of yoyo 'cleanser' bitters and fields Swedish bitters herbal preparations following sub-chronic administration in ratsMartins Ekor, Odusoga Adewale Osonuga, Adesina Olalekan Odewabi et al.Problem statement: Owing to numerous adverse effects of most orthodox pharmaceuticals, the use of herbal remedies in treatment and prevention of diseases is gaining much attention, especially in developing countries. The increase patronage of these remedies is often predicated on the assumption that they are harmless since they are prepared from natural sources. However, toxicity related to herbal medicines is … …American Journal of Pharmacology and Toxicology, Vol. 5, Issue 4 · 13 Jun 2011 · 10,198 accessesView PDFCite