105 results for “Injury”

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Research ArticleOpen accessEvery word in the titleNeuroprotection Afforded by GABA Against Oxygen-Glucose Deprivation-Induced Injury in Rat Cortical Brain Slices: An Hormetic Dose-Response EffectLorenzo Ricci, Massimo Valoti, Giampietro Sgaragli, Maria FrosiniThe aim of the present investigation was to assess neuroprotection exerted by GABA (100 nM-100 mM) in rat cortical brain slices subjected to oxygen-glucose deprivation and reoxygenation. Neuronal injury and neuroprotection were assessed by measuring the release of glutamate and lactate dehydrogenase and tissue water content. Results demonstrate that GABA exerted neuroprotective effects according to a U-shaped, hormetic-like, concentration-response curve, … …American Journal of Pharmacology and Toxicology, Vol. 3, Issue 1 · 31 Mar 2008 · 7,166 accessesView PDF Cite

Research ArticleOpen accessEvery word in the titleEvidences of Apoptosis in Hepatitis C Virus-Infected Hepatocytes and Peripheral Blood Monocuclear Cells in the Absence of Liver InjuryViviana Falcón, Nelson Acosta-Rivero, Mineko Shibayama et al.Understanding the mechanism of Hepatitis C Virus (HCV) pathogenesis is an important part of HCV research. In this study, the presence of apoptosis in HCV-infected liver and Peripheral Blood Mononuclear Cells (PBMC) from patients positive for anti-HCV antibodies and negative for serum HCV-RNA was investigated. The samples obtained from 21 patients were studied by in situ Hybridization (ISH), Immunofluorescence, TUNEL … …American Journal of Infectious Diseases, Vol. 1, Issue 1 · 31 Mar 2005 · 6,975 accessesView PDF Cite

Research ArticleOpen accessEvery word in the titleTraction Enhancing Products Affect Maximum Torque at the Shoe-Floor Interface: A Potential Increased Risk of ACL InjuryMorse, A., M.M. Mansfield et al.The knee is one of the most frequently injured joints in the body, between 100 000 and 400 000 Anterior Cruciate Ligament (ACL) injuries occur in the United States each year. This investigation explores the impact of wipe- or spray-on sneaker products used to increase traction between shoes and hardwood courts on the loading of the ACL. Specifically, the maximum … …American Journal of Engineering and Applied Sciences, Vol. 9, Issue 4 · 28 Sep 2016 · 8,327 accessesView PDF Cite

Research ArticleOpen accessEvery word in the titleMoringa oleifera Leaves Extract Attenuates Neuropathic Pain Induced by Chronic Constriction InjuryJurairat Khongrum, Jintanaporn Wattanathorn, Supaporn Muchimapura et al.Problem statement: Neuropathic pain, a challenge of this decade, has been reported to be associated with the diversity conditions including diabetes. At present, there are no conventional analgesics that can effectively treat neuropathic pain with a satisfactory outcome. Due to the limitation of therapeutic efficacy, the searching for novel effective remedies in the management of neuropathic pain is required. Approach: … …American Journal of Applied Sciences, Vol. 9, Issue 8 · 18 Jun 2012 · 17,239 accessesView PDF Cite

Research ArticleOpen accessEvery word in the titleEffect of Dietary Kaempferia parviflora on Ischemic Brain Injury in the ratWathita Phachonpai, Sinthuporn Maharun, Supaporn Muchimapura et al.Problem statement: Stroke often causes irreversible neuronal damage and related behavioral deficits. The lack of effective and widely applicable pharmacological treatments for ischemic stroke patients may explain a growing interest in traditional plant medicines. We investigated the ability of consuming Kaempferia parviflora extract, a Thai medicinal plant reputed for neuroprotective effects against brain damage, reduced infarct volume and improve neurological … …OnLine Journal of Biological Sciences, Vol. 12, Issue 1 · 20 Mar 2012 · 9,088 accessesView PDF Cite

Review ArticleOpen accessIn the keywordsSARS-CoV-2-Induced Damage on the Cardiovascular System: Molecular MechanismsMel·lina Pinsach-Abuin, Ramon Brugada TerradellasSince its emergence in late December 2019, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) - the causative agent of coronavirus disease 2019 (COVID-19) - has spread rapidly world-wide, becoming a global pandemic in March 2020 that is still active. In addition to the severe pulmonary damage, clinical studies have reported that COVID-19 is associated with the development of cardiovascular … …American Journal of Infectious Diseases, Vol. 17, Issue 4 · 25 Nov 2021 · 6,791 accessesView PDF Cite

Research ArticleOpen accessIn the keywordsGynaecologic NephrologyNaheed Ansari, Jolina Santos, Fuad Spath, Srujana PolsaniRenal issues are commonly encountered in females. They can occur both in pregnant and nonpregnant females. Many physiologic changes occur during pregnancy to accommodate the growing fetus. Pregnancy is characterized by changes in blood pressure and expansion of total body volume which results in high glomerular filtration rate. The common renal problems seen in pregnant females are hypertension, proteinuria with … …Current Research in Medicine, Vol. 3, Issue 2 · 4 Aug 2012 · 7,314 accessesView PDF Cite

Research ArticleOpen accessIn the keywordsSepticemia: The Principal Killer of Burns PatientsB. R. Sharma, Virendar Pal Singh, Sumedha Bangar, Neha GuptaBurn injury is a major problem in many areas of the world and it has been estimated that 75% of all deaths following burns are related to infection. Burns impair the skin’s normal barrier function thus allowing microbial colonization of the burn wounds and even with the use of topical antimicrobial agents, contamination is almost unavoidable. It is therefore essential … …American Journal of Infectious Diseases, Vol. 1, Issue 3 · 30 Sep 2010 · 7,022 accessesView PDF Cite

Case ReportOpen accessIn the keywordsAn Unusual Case of Leptospirosis Presenting as Glomerulonephritis With CrescentsFelipe Guedes Bezerra, Ana Flávia de Holanda Veloso, Yago Sucupira Amaral et al.Leptospirosis is a zoonosis caused by the spirochete Leptospira, which commonly affects the kidneys. Varied renal findings, most commonly tubulointerstitial nephritis, are found in human kidney biopsies and in vivo models. Remarkably, glomeruli are usually spared in this disease. However, some cases report evidence of glomerular damage. We describe a case of leptospirosis with fibroepithelial crescents, a rare histopathological finding. …American Journal of Infectious Diseases, Vol. 22, Issue 1 · 6 Aug 2026 · 1,011 accessesView PDF Cite

Case ReportOpen accessIn the keywordsSurvival Following Severe Paraquat Poisoning a Case Study from the Andaman and Nicobar IslandsShiv Shankar Singh, Colin Sanchez, Prasan Kumar PandaParaquat poisoning continues to pose a significant public health challenge in the Andaman and Nicobar Islands, largely due to its alarmingly high mortality rate. In this report, we present the case of a 39-year-old male farmer who ingested 30 mL of paraquat with the intent of suicide. Initially, the patient underwent prompt gastric lavage and exhibited relative stability. Upon admission, … …American Journal of Pharmacology and Toxicology, Vol. 19, Issue 1 · 22 Jan 2025 · 10,605 accessesView PDF Cite