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53 articles for “Gene Regulation”
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Research ArticleOpen accessIn the abstractThe Silencing of Septin 1 via Synthetic siRNAs in Schizosaccharomyces pombeSemih Ekimler, Merve Yilmazer, Ercan AricanSeptins are evolutionary conserved GTP-binding proteins and form heterooligomers in cells to interact with cytoskeleton. The main roles of septins in cell are cytokines, membrane interactions, vesicle trafficking and microtubule and actin organization. Non-coding RNAs are key players of gene expression regulation. Small-interfering RNAs (siRNAs) belong to non-coding RNAs, are characterized by sequence complementarity to their target mRNAs. siRNAs silence … …OnLine Journal of Biological Sciences, Vol. 17, Issue 1 · 31 Mar 2017 · 7,237 accessesView PDFCite
Research ArticleOpen accessIn the abstractIn silico Analysis of 4CL Family in Scutellaria baicalensis through Biocomputational Tools and ServersGuoming Li, Xiaozhong Lan, Xiaorong Shui et al.The gene sequences of 4-coumarate:coenzyme A ligase (4CL) family of Scutellaria baicalensis came from the GenBank Database. With help of some bioinformatics tools such as Vector NTI Suite 8, ProtParam and SWISS-MODEL and so on, a series of biological information of their nucleic acid sequences and amino acid sequences were predicted and analyzed and the results were revealed as following: … …American Journal of Biochemistry and Biotechnology, Vol. 13, Issue 1 · 15 Feb 2017 · 7,864 accessesView PDFCite
Review ArticleOpen accessIn the abstractVascular Endothelial Growth Factor: An Overview Across Multiple Disease ConditionsMiriam CanaveseVascular Endothelial Growth Factor (VEGF) is the major player in the regulation of physiological angiogenesis as well as it has also been implicated in pathological angiogenesis, associated with cancers and other conditions, among which psoriasis, autoimmune diseases and visual loss in macular degeneration. Interestingly, three regulatory Single Nucleotide Polymorphisms (rSNPs) in the promoter region of VEGF-A gene have been significantly … …American Journal of Pharmacology and Toxicology, Vol. 10, Issue 1 · 6 May 2015 · 7,099 accessesView PDFCite
Research ArticleOpen accessIn the abstractThe Role of Nf-Kappa and HDCA and Implication of Oxidative Stress in Airway Inflammation of Chronic Obstructive Pulmonary DiseaseGhada A. Abdallah, Nevine M. Abd-Elfattah, Hala M. Ghanem et al.Oxidative stress has been implicated in the pathogenesis of Chronic Obstructive Pulmonary Disease (COPD), due to its effect on proinflammatory gene transcription. Oxidants/antioxidants imbalance is responsible for disease development. The study was designed to assess oxidative stress and inflammation in COPD patients. The level of TNF-α and IL-8 in sputum and BAL were compared. NF-κB and HDAC were measured in … …American Journal of Biochemistry and Biotechnology, Vol. 10, Issue 4 · 4 Dec 2014 · 6,836 accessesView PDFCite
EditorialOpen accessIn the abstractAre Heat Shock Proteins Druggable Candidates?Tawanda Zininga, Addmore ShonhaiBanumathy, G., V. Singh, S.R. Pavithra and U. Tatu, 2003. Heat shock protein 90 function is essential for Plasmodium falciparum growth in human erythrocytes. J. Biol. Chem., 278: 18336-18345. DOI: 10.1074/jbc.M211309200 Brehmer, D., S. Rudiger, C.S. Gassler, D. Klostermeier and L. Packschies et al., 2001. Tuning of chaperone activity of Hsp70 proteins by modulation of nucleotide exchange. Nature Structural Molecular … …American Journal of Biochemistry and Biotechnology, Vol. 10, Issue 4 · 2 Dec 2014 · 8,166 accessesView PDFCite
Research ArticleOpen accessIn the abstractGENE IMPRINTING: ENGRAVING THE PATHOGENESIS OF HERIDETARY DISEASESSandeep Satapathy, Roshan Kumar Singh, Harikrishnan RajendranGene imprinting has conduited the scope of our understanding of phenotypic expression and its corelation with constituent genotype. It is an epigenetic process that involves DNA methylation and histone modulation to attain monoallelic gene expression without altering the genetic sequences. A distinctive model of non-mendelian genetics, imprinting extends the control over expression of traits and selection of the allele that … …American Journal of Immunology, Vol. 10, Issue 1 · 12 Feb 2014 · 7,682 accessesView PDFCite
Research ArticleOpen accessIn the abstractPOTENTIAL AMELIORATIVE ROLE OF N-ACETYLCYSTEINE AGAINST TESTICULAR DYSFUNCTION INDUCED BY TITANIUM DIOXIDE IN MALE ALBINO RATSAhmed Farag El-Kirdasy, Mohamed Abdo Nassan, Ahmed Abdel Aziz Baiomy et al.In this study, we examined the ameliorative action of N-Acetylcysteine (NAC) against Titanium Dioxide (TiO2) induced testicular degeneration in albino rats. Adult male albino rats were given saline as a control group, TiO2 (1200 mg kg-1 BW), NAC (100 mg kg-1 BW) and co-treatment of NAC and TiO2 as a protective group for 3 months. Testicular tissues were extracted for … …American Journal of Pharmacology and Toxicology, Vol. 9, Issue 1 · 31 Dec 2013 · 7,900 accessesView PDFCite
Research ArticleOpen accessIn the abstractDetecting Patterns in 5’ Untranslated Regions of Genes Involved in the Regulation of Blood Pressure and Oxidative StressMaria Sanchez-Aguilar, Luz Ibarra-Lara, Beatriz Zamora-Lopez et al.Hypertension is a chronic physical condition with multifactorial causes. Although genetic factors have been associated to this pathological condition, characterization of the sequence patterns in the regulatory sites, for example, in 3’ or 5’ Untranslated Regions (UTR), remains to be explored. In particular, the 5’ UTR of genes associated with the regulation of blood pressure and oxidative stress are analyzed … …Current Research in Medicine, Vol. 4, Issue 2 · 27 Nov 2013 · 7,283 accessesView PDFCite
Research ArticleOpen accessIn the abstractPolymorphisms in the 5’ Flanking Region and First Exon of Insulin-Like Growth Factor 1 Gene in Southern Populations of BuffaloSaber Khederzadeh, Ahmad YazdanpanahThe Insulin-like Growth Factor 1 (IGF-1) system plays a critical endocrine role controlling nutrient metabolism in animals and it is a group of structurally-related polypeptides that regulate the growth of many types of mammalian cells. In liver, IGF-1 is dynamically regulated by lactation and energy balance. Less is known about the regulation of IGF-1 and IGF-binding protein mRNA in reproductive … …American Journal of Biochemistry and Biotechnology, Vol. 9, Issue 3 · 21 Sep 2013 · 6,846 accessesView PDFCite
Research ArticleOpen accessIn the abstractPolymorphism of Insulin-Like Growth Factor 1 Gene in Najdi Cattle PopulationsAhmad Yazdanpanah, Khalil Mirzadeh, Morteza Mamouei et al.The Insulin-like Growth Factor 1 (IGF-1) system plays a critical endocrine role controlling nutrient metabolism in dairy cattle and it is a group of structurally-related polypeptides that regulate the growth of many types of mammalian cells. In liver, IGF-1 is dynamically regulated by lactation and energy balance. Less is known about the regulation of IGF-1 and IGF-binding protein mRNA in … …American Journal of Biochemistry and Biotechnology, Vol. 9, Issue 3 · 21 Sep 2013 · 7,154 accessesView PDFCite