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Research ArticleOpen accessEvery word in the titleBridging Innovation and Access: Randomized, Single-Dose, Open-Label, Parallel-Group Bioequivalence Study of Generic and Innovator Injection Semaglutide in IndiaMayur Madhav Mayabhate, Nitin Kapure, Akhilesh Sharma, Radhakrishna VaddemSemaglutide, a long-acting Glucagon-Like Peptide-1 (GLP-1) receptor agonist, is effective in improving glycemic control, reducing body weight, and lowering cardiovascular risk in Type 2 Diabetes Mellitus (T2DM). Limited accessibility of the innovator formulation underscores the need for bioequivalent generic alternatives. To assess the pharmacokinetic bioequivalence of a synthetic Semaglutide Injection (2 mg/1.5 mL) developed by Alkem Laboratories Ltd., India, compared … …American Journal of Pharmacology and Toxicology, Vol. 20, Issue 1 · 20 Apr 2026 · 2,626 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleDose-Dependent Neurotoxic Effects of Monosodium Glutamate and its Potential Genetic Transmission in MiceYanan Zou, Qiong Liang, Lu Liu et al.This study aimed to preliminarily investigated the neurotoxic effects of monosodium glutamate on mice and their pups, and the potential possibility of a genetic mechanism influencing the pups. In this study, mice were given different doses of Monosodium Glutamate (MSG) at doses of 2.0 or 4.0 g/kg body weight for 10 continuous days, and its impacts on both the mice … …American Journal of Biochemistry and Biotechnology, Vol. 21, Issue 3 · 14 Nov 2025 · 3,031 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleCoix lacryma-jobi L. Nutritional Value Concerning Nitrogen Fertilizer DosesTaufan Purwokusumaning Daru, Mayang Sari, Hamdi MayuluCoix lacryma-jobi L., as animal feed is considered a cereal plant from the Poaceae or Gramineae family. We aimed to determine the influence of different doses of Nitrogen (N) fertilizer on Coix lacryma-jobi L. It was conducted in the Lempake Village area; and the Chemical and biochemical laboratory of agricultural products and animal husbandry nutrition laboratory at Mulawarman University from … …American Journal of Animal and Veterinary Sciences, Vol. 18, Issue 2 · 3 Jun 2023 · 6,221 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleThiosemicarbazide Induces Partial Myoclonic, Generalized Tonic-Clonic and Status Epilepticus Seizures Depending on the Dose in the RatAnwar Satef, Sofia El Amoury, Soumaya El Ganouni et al.The present study aimed to characterize the seizures produced by injections of Thiosemicarbazide (TSC), a glutamic acid decarboxylase inhibitor. It aimed also to evaluate the anticonvulsant effect of the antiseizure medications Phenobarbital (PHB), Valproate (VPA), and Phenytoin (PNT) and of the antipsychotics Chlorpromazine (CPZ) and Haloperidol (HAL) as well as the antidepressant SSRI, Fluoxetine (FXT). Male Wistar rats received TSC … …Neuroscience International, Vol. 13, Issue 1 · 4 Mar 2023 · 10,301 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleEffects of Humic Acid Dosage and Fermentation Time with Bacillus subtilis on Nutrient Content and Quality of Palm Kernel CakeMirnawati, Gita Ciptaan, Yoga Seftiadi, Malik MakmurThis study aims to determine the effects of humic acid dosage and fermentation time with Bacillus subtilis on the nutrient content and quality of Palm Kernel Cake (PKC). A Completely Randomized Design (CRD) with a 3 × 4 factorial pattern and 3 replications was applied. The present experiment considered two major parameters, termed A and B. Factor A represents the … …American Journal of Animal and Veterinary Sciences, Vol. 17, Issue 1 · 15 Feb 2022 · 6,699 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleVitamin D Supplements Tone Down the Progression of Atheromatous Plaque Formation in a Dose-Dependent MannerAhmed Farouk, Khalid M. Mohany, Magdy Algowhary et al.Hypovitaminosis D has a negative impact on the cardiovascular system. We performed the current study to investigate the expression of Vitamin D Receptor (VDR) in atherosclerotic human male aortas and to examine the effect of different doses of Vit. D supplementation on VDR expression in the aortas of male rats fed a High-Fat Diet (HFD). Human participants included 50 atherosclerotic … …American Journal of Biochemistry and Biotechnology, Vol. 17, Issue 3 · 5 Oct 2021 · 6,724 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleFSH Receptor and Ki-67 Protein Expressions of Endometrial Macaque in Mid-Luteal Phase after Exposure to Various Doses of Recombinant FSH and Fixed-Dose of GnRH AgonistNurhuda Sahar, Ponco Birowo, Rosalina Thuffi et al.There are many advances in Assisted Reproductive Technologies (ARTs). However, implantation rates are still low. The embryo implantation is a mutual interaction between the blastocyst and endometrium. This study aimed to investigate the endometrial cell proliferation stimulated by recombinant Follicle-Stimulating Hormone (rFSH) in various doses by looking at FSH-Receptor (FSHR) and Ki-67 protein expressions. The studied samples were Stored Biological … …OnLine Journal of Biological Sciences, Vol. 21, Issue 2 · 28 May 2021 · 6,347 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleHigh-Dose Vitamin D3 Intake Is Associated with Decreased Symptoms of Multiple SclerosisMichelle L. Steinwart, David M. DuriancikMultiple sclerosis (MS) is one of the most widespread disabling autoimmune neurological conditions of adults between the ages of 20 and 40 globally. Medical researchers do not completely understand the possible causes of MS, nor have they determined the rate of progression. A limited number of clinical trials conducted in recent years have explored the link between vitamin D deficiency … …American Journal of Immunology, Vol. 14, Issue 1 · 4 Sep 2018 · 9,283 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleTHE EFFECTS OF ORAL ADMINISTRATION OF DIFFERENT DOSES OF HYDROALCOHOLIC EXTRACT OF SILYMARIN ON STATUS OF SERUM TRACE ELEMENTSJ. Sajedianfard, S. Nazifi, H. A. ShamsaeiIn this research, the effect of oral administration of different doses of hydroalcoholic extract of silymarin on the status of trace elements with antioxidant properties (Se, Cu, Zn, Mn and Fe) was studied. Fifty male rats were randomly used in five groups including healthy control group (treated by saline), diabetic control group (treated by saline) and three diabetic groups that … …American Journal of Animal and Veterinary Sciences, Vol. 9, Issue 3 · 24 Oct 2014 · 6,644 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleCOLORIMETRIC DETERMINATION OF CEFQUINOME SULPHATE IN BULK AND DOSAGE FORM USING AMMONIUM MOLYBDATEShaza Wageialla Shantier, Elrasheed Ahmed GadkariemThis study was designed to develop two colorimetric methods for the determination of Cefquinome Sulphate (CS) in bulk and dosage forms using two different concentrations of molybdenum solution. The developed methods were based on the oxidation of CS with 2% ammonium molybdate, in the presence of sulphuric acid, producing a green colored product with λmax at 409 nm (Method I) … …American Journal of Applied Sciences, Vol. 11, Issue 2 · 20 Dec 2013 · 7,051 accessesView PDFCite