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32 articles for “Alkaline Phosphatase”
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Research ArticleOpen accessIn the abstractConcentration-Effect, Incidence and Mechanism of Nevirapine HepatotoxicityAdikwu Elias, Brambaifa NelsonNevirapine is a dipyridozepinone non nucleoside reverse transcriptase inhibitor approved for use in HIV-infected patients. Its efficacy has been well demonstrated in numerous clinical trials. It has activity against HIV-1 but does not have significant activity against HIV-2 or other retroviruses. Nevirapine is used as one of the components of highly active antiretroviral therapy in HIV patients and in the … …American Journal of Pharmacology and Toxicology, Vol. 8, Issue 1 · 19 Apr 2013 · 8,161 accessesView PDFCite
Research ArticleOpen accessIn the abstractEffect of Leptospirosis on the Concentrations of Streptomycin in Liver and Kidneys of PigsLabrini V. Athanasiou, Vassilios Papatsiros, George Valiakos et al.Leptospirosis is a re-emerging infectious disease with zoonotic potential. Pigs are reservoir hosts of the pathogen and streptomycin is among the antibiotics proposed to eliminate leptospiral infection. The purpose of this study was to determine streptomycin concentrations and the possible effect of the presence of Leptospira in the liver and kidneys on drug distribution. Six pigs with leptospirosis and six … …American Journal of Animal and Veterinary Sciences, Vol. 8, Issue 1 · 28 Mar 2013 · 7,488 accessesView PDFCite
Research ArticleOpen accessIn the abstractAcute Phase Proteins, Lipid Profile and Proinflammatory Cytokines in Healthy and Bronchopneumonic Water Buffalo CalvesSabry M. El-Bahr, Wael M. EL-DeebThe aim of the present study was to evaluate the diagnostic value of Acute Phase Proteins (APP), lipid profiles and proinflammatory cytokines in healthy and bronchopneumonic water buffalo calves. Therefore, sixty water buffalo calves (9±1 month old, 175±15 kg) were divided into two equal groups, the first group represented healthy, control, calves whereas calves of the second group were affected … …American Journal of Biochemistry and Biotechnology, Vol. 9, Issue 1 · 18 Mar 2013 · 8,417 accessesView PDFCite
Research ArticleOpen accessIn the abstractHepatoprotective Effect of Vitamin EElias Adikwu, Brambaifa NelsonDrugs and some chemical agents are known to induce hepatotoxicity in humans which is of great concern to clinicians. Chemical agents are been screen daily for their hepatoprotective properties. Among these chemical agents is vitamin E which has drawn wide attention due to it reported hepatoprotective property as reported by researchers. This study collected and evaluated reports to ascertain the … …American Journal of Pharmacology and Toxicology, Vol. 7, Issue 4 · 15 Mar 2013 · 8,006 accessesView PDFCite
Research ArticleOpen accessIn the abstractGastroprotective Effect and Safety Assessment of Zanthoxylum Zanthoxyloides (Lam) Waterm Root Bark ExtractAlex Boye, George Asumeng Koffuor, Johnson Nyarko Boampong et al.Problem statement: Gastrointestinal ulcers account significantly for morbidity and mortality in Ghana. The study therefore investigated the gastroprotective effect of an ethanolic root bark extract of Zanthoxylum zanthxyloides and its safety for us. Approach: Gastric ulceration was induced in Sprague-Dawley rats with Indomethacin (25 mg kg-1, p.o) and was treated with 150, 250, or 500 mg kg-1 of the extract, … …American Journal of Pharmacology and Toxicology, Vol. 7, Issue 2 · 7 Aug 2012 · 8,499 accessesView PDFCite
Research ArticleOpen accessIn the abstractEvaluation of Prophylactic and Therapeutic Effects of Silymarin on Diazepam-Induced Hepatotoxicity in CatsBahman Mosallanejad, Reza Avizeh, Hossien NajafzadehProblem statement: Diazepam is commonly administered for seizure control and appetite stimulant in cats. Cats may develop acute fatal hepatic necrosis after receiving oral diazepam for several days. The aim of this study was to detect the protective action of silymarin on diazepam-induced hepatotoxicity in cats. Approach: About 25 healthy cats were randomly allotted to five equal groups. Animals in … …American Journal of Applied Sciences, Vol. 8, Issue 9 · 29 Jul 2011 · 7,430 accessesView PDFCite
Research ArticleOpen accessIn the abstractHepatotoxicity Due to Histamine Trifluoro-Methyl Toluidide, Amthamine, R-(-)-α-Methyl Histamine and Clobenpropit (H1R-H4R-Agonists, Respectively) in Rabbit Experimental ModelTrivendra Tripathi, Aijaz Ahmed Khan, Mohammad Shahid et al.Problem statement: Since in vivo studies looking for toxicological impact of histamine receptors-agonists in experimental models are fragmentary, the present study was designed to delineate the histopathological and biochemical changes in livers of rabbits treated with histamine receptors (H1R-H4R)-agonists. Approach: The cohort comprised of six groups (Group I control and Group II-VI treated) containing five rabbits each. Control-group received vehicle … …Current Research in Medicine, Vol. 1, Issue 1 · 30 Jun 2010 · 8,905 accessesView PDFCite
Research ArticleOpen accessIn the abstractEvaluation of the Toxic Effects of Dihydroartemisinin on the Vital Organs of Wistar Albino RatsA. U. Utoh-Nedosa, P. A. Akah, T. C. Okoye, C. O. OkoliProblem statement: The current surge in the use of Artemisinin based Combination Therapy (ACT) in the treatment of falciparium resistant malaria in the tropics and the potentials of Dihydroartemisinin (DHA), a member of the artemisinin family, to produce toxic effect in the vital organs (such as the liver, heart, lungs, intestine, spleen kidney and blood cells) necessitated this research. Approach: … …American Journal of Pharmacology and Toxicology, Vol. 4, Issue 4 · 31 Dec 2009 · 9,187 accessesView PDFCite
Research ArticleOpen accessIn the abstractBiochemical Changes in Wistar Rats on Oral Doses of Mistletoe (Loranthus micranthus)D. O. Edem, I. F. UsohProblem statement: To evaluate the effects of the water extract of the leaves of mistletoe (Loranthus micranthus) (traditionally used antidiabetic and antihypertensive) in male albino Wistar rats. Approach: The animals were divided into 4 groups (n = 6). Water extract of L. micranthus leaves was administered in graded doses of 0, 275, 551 and 827 mg kg-1 body weight (wt) … …American Journal of Pharmacology and Toxicology, Vol. 4, Issue 3 · 30 Sep 2009 · 8,547 accessesView PDFCite
Research ArticleOpen accessIn the abstractCamel's Milk Protects against Aluminum Chloride-Induced Toxicity in the Liver and Kidney of White Albino RatsFahaid Al-HashemProblem statement: Aluminum chloride (AlCl3) is commonly used in daily life but it can be potentially toxic. Therefore, the present study was carried out to investigate the protective effects of camel’s milk against aluminum-induced biochemical alterations and oxidative stress in the liver and kidney of white albino rats. Approach: White albino male rats (230-250 g) were divided into three groups … …American Journal of Biochemistry and Biotechnology, Vol. 5, Issue 3 · 30 Sep 2009 · 10,376 accessesView PDFCite