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Research ArticleOpen accessIn the abstractIn Silico and in Vitro Studies: Tryparedoxin Peroxidase Inhibitor Activity of Methotrexate for Antileishmanial ActivityRavi Kumar Gundampati, Shraddha Sahu, Avinash Kumar Srivastava et al.In order to understand the mechanism of molecular interactions at the active site of Tryparedoxin Peroxidase (Try P), homology modeling and docking studies were performed. We generated a Three-Dimensional (3D) model of target protein based on the Crystal structure of Leishmania Major Try PI (PDB ID: 3TUE) using modeler software. Docking analysis was carried out to study the effects of … …American Journal of Infectious Diseases, Vol. 9, Issue 4 · 28 Nov 2013 · 7,893 accessesView PDFCite
Research ArticleOpen accessIn the abstractDifferential Gene Expression in Zebrafish (Danio rerio) Following Exposure to Gaseous Diffusion Plant Effluent and Effluent Receiving Stream WaterBen F. Brammell, Andrew J. WiggintonProblem statement: The expression of six genes known to serve as bioindicators of environmental stress were examined using real-time quantitative PCR in liver tissue extracted from zebrafish (Danio rerio, Hamilton) exposed to effluent and effluent containing stream water associated with the Paducah Gaseous Diffusion Plant (PGDP). Approach: The PGDP, the only active uranium enrichment facility in the US, is located … …American Journal of Environmental Sciences, Vol. 6, Issue 3 · 30 Jun 2010 · 7,770 accessesView PDFCite
Research ArticleOpen accessIn the abstractPrediction of a Putative Functional Region in the Human Bax Protein by Computational AnalysisMaría Sánchez-Aguilar, Laurence A. Marchat, Absalom ZamoranoStructural domains are relevant elements for interactions between Bcl-2 family members to regulate apoptosis and cell survival. Although BH1-BH4 domains can be identified by their sequence and selective occurrence in Bcl-2-family members, structural regions have not been entirely determined yet. The functional residues of Bax, the most representative pro-apoptotic protein of the human Bcl-2 family, remain almost unknown. Here, we … …American Journal of Infectious Diseases, Vol. 3, Issue 2 · 30 Jun 2007 · 7,230 accessesView PDFCite
Research ArticleOpen accessIn the abstractCost-Effective Energy Refurbishment of Health Care Facilities in Heating Dominated Climates of Italian Backcountry. The Case Study of the Hospital Veneziale of IserniaRosa Francesca De Masi, Fabrizio Ascione, Gennaro Sosto, Giuseppe Peter VanoliMaximizing energy efficiency within hospitals and healthcare facilities is a major challenge for sustainable development and energy saving objectives. In this study, the case study of the public hospital of Isernia (Italian backcountry city) is proposed, being typical of the hospital building stock developed in reinforced concrete all around Italy in the last 40 years. Starting from deep on-site investigations, … …American Journal of Engineering and Applied Sciences, Vol. 10, Issue 3 · 25 Sep 2017 · 8,352 accessesView PDFCite
Research ArticleOpen accessIn the abstractMicro-Retargeted Advertising and Online Shoppers' Motivation in NigeriaJoseph Wilson, Yusuf Mu'azu, Fredrick WilsonOnline shopping is increasingly gaining popularity worldwide, as the experience is perceived not only to replicate but sometimes exceed that of traditional retail. The rapid transformation of the e-commerce sector compels online stores to adopt innovative strategies to attract and retain customers, enhance service delivery, increase product visibility, and remain competitive. The integration of big data and artificial intelligence has … …Journal of Social Sciences, Vol. 21, Issue 1 · 15 Aug 2025 · 5,437 accessesView PDFCite
Research ArticleOpen accessIn the abstractProbabilistic Seismic Hazard Deaggregation for Karaj City (Iran)Hadi JarahiIn this study the results of PSHA deaggregation for 5%-damped 0.2, 0.5, 2 and 4 s spectral accelerations, corresponding to Mean Return Periods (MRPs) of 50 and 475 yr for Karaj city was presented. The aim of this paper is to quantify the dominant events that have the most contribution on ground-motion exceedance from the above mentioned hazard levels. The … …American Journal of Engineering and Applied Sciences, Vol. 9, Issue 3 · 16 Jun 2016 · 8,268 accessesView PDFCite
EditorialOpen accessIn the abstractNeutrophil Extracellular Traps as Therapeutic Targets for Inflammatory DiseaseRory R. KoenenNeutrophilic granulocytes, or neutrophils are the most abundant circulating white blood cell and constitute a first line of defense against pathogens. They are characterized by a large polymorphic lobular nucleus and the presence of many secretory granules in their cytoplasm. Neutrophils are essential for a functional host defense, as is evidenced by the occurrence of severe infections in individuals with … …American Journal of Pharmacology and Toxicology, Vol. 9, Issue 4 · 25 Feb 2015 · 8,737 accessesView PDFCite
Research ArticleOpen accessIn the abstractIN SILICO DESIGN OF THE M2 PROTON CHANNEL INHIBITORS OF H1N1 VIRUSUsman Sumo Friend Tambunan, Mochamad Reza Rahdiansyah, Arli Aditya ParikesitM2 proton channel of H1N1 Influenza A virus is the target protein anti-flu drugs amantadine and rimantadine. However, the two once powerful adamantane-based drugs lost their 90% bioactivity because of mutations of virus in recent twenty years. The resistance of influenza A virus to amantadine need to develop more effective adamantane-based drugs. Several research by molecular docking method have been … …OnLine Journal of Biological Sciences, Vol. 13, Issue 1 · 5 Jan 2013 · 7,999 accessesView PDFCite
Research ArticleOpen accessIn the abstractA Cyanobacterium Synechocystis sp. PCC 6803 Glutaredoxin Gene (slr1562) Protects Escherichia coli against Abiotic StressesAhmed Gaber, Salah El-Din El-AssalProblem statement: Glutaredoxins (GRXs) are ubiquitous small heat stable glutathione-dependent oxidoreductase enzymes that play a crucial role in plant development and response to oxidative stress. Approach: Cyanobacterium Synechocystis strain PCC 6803 contains two genes (slr1562 and ssr2061) encoding glutaredoxins. In the present investigation the slr1562 gene (grxC) was isolated and characterized. Results: The results revealed that the amino acid sequence … …American Journal of Agricultural and Biological Sciences, Vol. 7, Issue 1 · 5 Mar 2012 · 7,582 accessesView PDFCite
Research ArticleOpen accessIn the abstractMass Spectrometry/Mass Spectrometry Study on the Degradation of B-Aflatoxins in Maize with Aqueous Citric AcidA. Méndez-Albores, I. Nicolás-Vázquez, R. Miranda-Ruvalcaba, E. Moreno-MartÍnezDegradation of B-aflatoxins in maize by means of 1N aqueous citric acid was confirmed by the AFLATEST immunoaffinity column method, High Performance Liquid Chromatography (HPLC), tandem mass spectrometry (MS/MS) and computational information. The AFLATEST and HPLC assays showed that 96.7% degradation occurred in maize contaminated with 93 ng g-1 when treated with the aqueous citric acid. Two major products, produced … …American Journal of Agricultural and Biological Sciences, Vol. 3, Issue 2 · 30 Jun 2008 · 8,049 accessesView PDFCite