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Research ArticleOpen accessIn the abstractPrediction of a Putative Functional Region in the Human Bax Protein by Computational AnalysisMaría Sánchez-Aguilar, Laurence A. Marchat, Absalom ZamoranoStructural domains are relevant elements for interactions between Bcl-2 family members to regulate apoptosis and cell survival. Although BH1-BH4 domains can be identified by their sequence and selective occurrence in Bcl-2-family members, structural regions have not been entirely determined yet. The functional residues of Bax, the most representative pro-apoptotic protein of the human Bcl-2 family, remain almost unknown. Here, we … …American Journal of Infectious Diseases, Vol. 3, Issue 2 · 30 Jun 2007 · 7,235 accessesView PDF Cite

Research ArticleOpen accessIn the abstractComputer Aid Screening for Potential Antimalarial Choroquinone Compounds as Covid 19 Utilizing Computational Calculations and Molecular Docking StudyAsmaa Aboelnaga, Asmaa M. Fahim, Taghreed H. EL-SayedClick reaction of 4,7-dichloroquinoline (1) with thiosemicarbazide (2) to afford the corresponding 2-(7-chloroquinolin-4-yl)thiosemicarbazide (3) utilized ultrasonic irradiation which can cyclized easily with ethylacetoacetate to give the 3-(7-chloroquinolin-4-ylamino)-tetrahydro-6-methyl-2-thioxopyrimidin-4(1H)-one (4) via nucleophilic substitution reaction. The synthesized compounds was examined in vitro antimalarial activity with IC50 = 11.92, 25.37 μg/mL against chloroquinone drug. Furthermore, the theoretical investigation of most active compounds CQT and … …OnLine Journal of Biological Sciences, Vol. 20, Issue 4 · 30 Nov 2020 · 6,570 accessesView PDF Cite

Research ArticleOpen accessIn the abstractPrediction and Remediation of Water Quality in Monitoring Potential of Acid Mine DrainageNur Athirah Mohamad Basir, Wan Zuhairi Wan Yaacob, Nuur Hani Mohammed et al.Acid Mine Drainage (AMD) associated with both active and abandoned mining operations related to sulfide minerals, oxidation of pyrite affording an acidic solution that contains toxic metal ions. Result shows that pH value of water in Kg. Aur, Chini and Sg. Lembing are acidic with value of 2.81, 4.16 and 3.60 respectively. Maximum concentrations of heavy metals in the study … …American Journal of Engineering and Applied Sciences, Vol. 12, Issue 2 · 24 May 2019 · 7,014 accessesView PDF Cite

Research ArticleOpen accessIn the abstractMicro-Retargeted Advertising and Online Shoppers' Motivation in NigeriaJoseph Wilson, Yusuf Mu'azu, Fredrick WilsonOnline shopping is increasingly gaining popularity worldwide, as the experience is perceived not only to replicate but sometimes exceed that of traditional retail. The rapid transformation of the e-commerce sector compels online stores to adopt innovative strategies to attract and retain customers, enhance service delivery, increase product visibility, and remain competitive. The integration of big data and artificial intelligence has … …Journal of Social Sciences, Vol. 21, Issue 1 · 15 Aug 2025 · 5,440 accessesView PDF Cite

Research ArticleOpen accessIn the abstractCost-Effective Energy Refurbishment of Health Care Facilities in Heating Dominated Climates of Italian Backcountry. The Case Study of the Hospital Veneziale of IserniaRosa Francesca De Masi, Fabrizio Ascione, Gennaro Sosto, Giuseppe Peter VanoliMaximizing energy efficiency within hospitals and healthcare facilities is a major challenge for sustainable development and energy saving objectives. In this study, the case study of the public hospital of Isernia (Italian backcountry city) is proposed, being typical of the hospital building stock developed in reinforced concrete all around Italy in the last 40 years. Starting from deep on-site investigations, … …American Journal of Engineering and Applied Sciences, Vol. 10, Issue 3 · 25 Sep 2017 · 8,354 accessesView PDF Cite

Research ArticleOpen accessIn the abstractProbabilistic Seismic Hazard Deaggregation for Karaj City (Iran)Hadi JarahiIn this study the results of PSHA deaggregation for 5%-damped 0.2, 0.5, 2 and 4 s spectral accelerations, corresponding to Mean Return Periods (MRPs) of 50 and 475 yr for Karaj city was presented. The aim of this paper is to quantify the dominant events that have the most contribution on ground-motion exceedance from the above mentioned hazard levels. The … …American Journal of Engineering and Applied Sciences, Vol. 9, Issue 3 · 16 Jun 2016 · 8,278 accessesView PDF Cite

EditorialOpen accessIn the abstractNeutrophil Extracellular Traps as Therapeutic Targets for Inflammatory DiseaseRory R. KoenenNeutrophilic granulocytes, or neutrophils are the most abundant circulating white blood cell and constitute a first line of defense against pathogens. They are characterized by a large polymorphic lobular nucleus and the presence of many secretory granules in their cytoplasm. Neutrophils are essential for a functional host defense, as is evidenced by the occurrence of severe infections in individuals with … …American Journal of Pharmacology and Toxicology, Vol. 9, Issue 4 · 25 Feb 2015 · 8,740 accessesView PDF Cite

Research ArticleOpen accessIn the abstractIN SILICO DESIGN OF THE M2 PROTON CHANNEL INHIBITORS OF H1N1 VIRUSUsman Sumo Friend Tambunan, Mochamad Reza Rahdiansyah, Arli Aditya ParikesitM2 proton channel of H1N1 Influenza A virus is the target protein anti-flu drugs amantadine and rimantadine. However, the two once powerful adamantane-based drugs lost their 90% bioactivity because of mutations of virus in recent twenty years. The resistance of influenza A virus to amantadine need to develop more effective adamantane-based drugs. Several research by molecular docking method have been … …OnLine Journal of Biological Sciences, Vol. 13, Issue 1 · 5 Jan 2013 · 8,002 accessesView PDF Cite

Research ArticleOpen accessIn the abstractA Cyanobacterium Synechocystis sp. PCC 6803 Glutaredoxin Gene (slr1562) Protects Escherichia coli against Abiotic StressesAhmed Gaber, Salah El-Din El-AssalProblem statement: Glutaredoxins (GRXs) are ubiquitous small heat stable glutathione-dependent oxidoreductase enzymes that play a crucial role in plant development and response to oxidative stress. Approach: Cyanobacterium Synechocystis strain PCC 6803 contains two genes (slr1562 and ssr2061) encoding glutaredoxins. In the present investigation the slr1562 gene (grxC) was isolated and characterized. Results: The results revealed that the amino acid sequence … …American Journal of Agricultural and Biological Sciences, Vol. 7, Issue 1 · 5 Mar 2012 · 7,586 accessesView PDF Cite

Research ArticleOpen accessIn the abstractMass Spectrometry/Mass Spectrometry Study on the Degradation of B-Aflatoxins in Maize with Aqueous Citric AcidA. Méndez-Albores, I. Nicolás-Vázquez, R. Miranda-Ruvalcaba, E. Moreno-MartÍnezDegradation of B-aflatoxins in maize by means of 1N aqueous citric acid was confirmed by the AFLATEST immunoaffinity column method, High Performance Liquid Chromatography (HPLC), tandem mass spectrometry (MS/MS) and computational information. The AFLATEST and HPLC assays showed that 96.7% degradation occurred in maize contaminated with 93 ng g-1 when treated with the aqueous citric acid. Two major products, produced … …American Journal of Agricultural and Biological Sciences, Vol. 3, Issue 2 · 30 Jun 2008 · 8,054 accessesView PDF Cite