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78 results for “2A Peptide”
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Research ArticleOpen accessEvery word in the titleNaloxone benzoylhydrazone activates Extracellular Signal-Regulated Protein Kinases and modulates Nociceptin Opioid Peptide Receptor activityDeepak R. Thakker, Ghazi F. Altememi, Chitra D. Mandyam et al.Naloxone benzoylhydrazone (NalBzoH) is often used as a nociceptin opioid peptide (NOP) receptor antagonist. However, NalBzoH is also a mixed μ antagonist/κ and δ opioid agonist and its actions at the NOP receptor range from an antagonist to partial agonist, depending on the effector response/system studied. We now report that NalBzoH activates endogenously expressed κ3 opioid, but not NOP, receptors … …American Journal of Pharmacology and Toxicology, Vol. 2, Issue 2 · 30 Jun 2007 · 7,549 accessesView PDFCite
Research ArticleOpen accessEvery word in the titlePharmacophore Pattern Identification of Tachykinin Receptor Selective Peptide Agonists: Implications in Receptor SelectivityAnjali Dike, Indu R. Chandrashekaran, Anil K. Mantha et al.The mammalian tachykinin (TK) peptides and their three Neurokinin (NK1, NK2 and NK3) receptors represent an effector system with wide-ranging actions on neuronal, airway smooth muscle, mucosal, endothelial, immune, inflammatory and remodeling cell function. Recent clinical and preclinical data suggests the pathophysiological role of TKs in various diseases including asthma, emesis and depression. The TK-NK receptor interactions and overlapping functions … …American Journal of Biochemistry and Biotechnology, Vol. 3, Issue 4 · 31 Dec 2007 · 6,691 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleIsolation of the Antimicrobial Cyclic Peptide Subtilosin a from a Gut-Associated Bacillus subtilis StrainGhislain Schyns, Claudia R. Serra, Adriano O. Henriques et al.The endospore-forming Bacillus subtilis has been used as probiotics over the last 50 years. However, little is known on how Bacillus spp act in the gut compared to other well-characterized probiotics such as lactic acid bacteria. It is believed that the competitive exclusion of pathogens results from different mode of action notably the production of antimicrobial compounds such as bacteriocins. … …American Journal of Biochemistry and Biotechnology, Vol. 9, Issue 3 · 21 Sep 2013 · 7,678 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleMolecular Dynamics Simulation of DENV RNA-Dependent RNA-Polymerase with Potential Inhibitor of Disulfide Cyclic PeptideUsman Sumo Friend Tambunan, Raima Syahidah Noors, Arli Aditya Parikesit et al.Problem statement: Our researches have proposed two ligands of disulfide cyclic polypeptide, which are CDEEC and CDGSC as potential inhibitor of DENV RNA-dependent RNApolymerase by molecular docking. Approach: Methodological approach was conducted to determine the best ligand to act as inhibitor. Molecular docking simulation was conducted without a solvent in which enzyme was made rigid and ligand was left free … …OnLine Journal of Biological Sciences, Vol. 11, Issue 2 · 30 Sep 2011 · 8,441 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleOptimization of Hydrolysis Conditions for Obtaining Antithrombotic Peptides from Tenebrio Molitor LarvaeFangyuan Chen, Han Jiang, Yini Gan et al.Tenebrio molitor larvae was hydrolyzed by pepsin and trypsin for preparing high antithrombotic activity hydrolysate. The significant variables were selected according to the Plackett-Burman design and further optimized by the Response Surface Methodology (RSM). Four factors, including substrate concentration, pepsin digestion time, pepsin amount and trypsin amount, respectively, influenced significantly on the hydrolysis effectiveness. The best hydrolysis conditions obtained using … …American Journal of Biochemistry and Biotechnology, Vol. 15, Issue 2 · 20 May 2019 · 8,722 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleOptimization of Hydrolysis Conditions for the Production of Iron-Binding Peptides from Scad (Decapterus maruadsi) Processing ByproductsWenting Zhang, Yanan Li, Jie Zhang, Guangrong HuangThe scad (Decapterus maruadsi) processing byproduct (SPB) was hydrolyzed by four commercial enzymes, namely, trypsin, flavourzyme, protamex and alcalase, for preparing high Iron-Binding Capacity (IBC) hydrolysate. Alcalase was the best choice for obtaining high IBC hydrolysate from SPB. Response surface methodology using a central-composite design was employed to optimize the enzymatic hydrolysis conditions with alcalase to obtain a maximum hydrolysate … …American Journal of Biochemistry and Biotechnology, Vol. 12, Issue 4 · 17 Oct 2016 · 7,589 accessesView PDFCite
Research ArticleOpen accessIn the keywordsCytocompatibility and Antimicrobial Properties of Silver Nanoparticles-Loaded AMPs in the Oral CavityYanli Lv, Weikai ZhangPostoperative infection following oral metal implantation is a key factor that affects the success rate of surgery. This infection is mainly caused by bacterial biofilms. Traditional single antibacterial coatings have limitations, including a narrow antibacterial spectrum and poor cytotoxicity or stability. This study combined silver nanoparticles (AgNPs) and the synthetic antimicrobial peptide GL13K using electrostatic self-assembly technology to create a … …American Journal of Biochemistry and Biotechnology, Vol. 22, Issue 1 · 24 Apr 2026 · 1,685 accessesView PDFCite
Research ArticleOpen accessIn the keywordsTwo Co-Expression Strategies for Eicosapentaenoic Acid Production in Mortierella alpinaXin Tang, Haiqin Chen, Xiaoke Zhang et al.The omega-3 long-chain Polyunsaturated Fatty Acid (PUFA) Eicosapentaenoic Acid (EPA) has beneficial effects on human health, leading to its use in health products and foods. The oleaginous microorganism Mortierella alpina has been used in the industrial production of Arachidonic Acid (AA). The omega-3 desaturase oPpFADS17 is a key enzyme in the bioconversion of AA to EPA from Phytophthora parasitica and … …American Journal of Biochemistry and Biotechnology, Vol. 15, Issue 4 · 5 Dec 2019 · 7,480 accessesView PDFCite
Research ArticleOpen accessIn the keywordsImmunological Response in Bovine Lymph Nodes Stimulated with Subunits VaccinesGabriel Andres Tafur Gomez, Marlene Isabel Vargas, Joaquin Hernan Patarroyo Salcedo et al.The vaccination process belongs to the public health intervention methodologies that help prevent infections. Vaccinations performed successfully in the history of medicine reported the significance of this procedure to increase the quality of life, prevent zoonoses and improve animal production. Vaccine emergence remained without exact rules for a long time, maintaining a close relationship with pathogens. However, subunit vaccines, with … …American Journal of Immunology, Vol. 9, Issue 2 · 20 Jun 2013 · 7,319 accessesView PDFCite
Research ArticleOpen accessIn the keywordsHigh Incidence of Disorder-Promoting Amino Acids in the Amino Terminus of Mature Proteins in Bacillus subtilisGuangqiang Wang, Yining Dong, Haiqin Chen et al.Problem statement: Exported polypeptides are usually synthesized as preproteins which are composed with mature domains and the signal peptides. The foreign proteins are usually inefficiently secreted by the aid of signal peptides. Although we know that the mature protein played an important role in the protein export process, we do not know what properties of the mature domains are critical … …American Journal of Biochemistry and Biotechnology, Vol. 7, Issue 4 · 2 Feb 2012 · 8,255 accessesView PDFCite