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336 articles for “In Vitro”
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Research ArticleOpen accessIn the abstractDevelopment of Curcumin Based Ophthalmic FormulationD. Anjana, K. Anitha Nair, N. Somashekara et al.Problem statement: Ophthalmic drug delivery system has been a major challenge due to the distinctive and unique anatomy of the eye. The use of phytochemicals for the application in ocular disease has not been investigated much, due to poor pharmacokinetics of phytochemical and hence poor therapeutic efficacy. Approach: Curcumin is one such phytochemical known for its medicinal properties, but its … …American Journal of Infectious Diseases, Vol. 8, Issue 1 · 24 Feb 2012 · 15,409 accessesView PDFCite
Research ArticleOpen accessIn the abstractStudy on Survival of Chlamydia trachomatis in the Presence of Antichlamydial DrugsApurb Rashmi Bhengraj, Pragya Srivastava, Harsh Vardhan et al.Problem statement: Recurrent genital Chlamydia trachomatis infections due to treatment failures may results in complex sequelae leading to reproductive complexity and morbidity. It can be resulted by the heterotypic resistance with decreased drug susceptibility characteristic of the isolate. Studies are needed to understand the treatment failures and resistance characteristic of C. trachomatis. Hence, in vitro study was conducted on C. … …American Journal of Infectious Diseases, Vol. 8, Issue 1 · 20 Feb 2012 · 7,774 accessesView PDFCite
Research ArticleOpen accessIn the abstractRole of Endometrial Thickness on Intracytoplasmic Sperm InjectionMohammed Al-SunaidiProblem statement: Endometrial receptivity is a key factor in successful outcome of in vitro fertilization. The endometrial receptivity is determined clinically by estimation of endometrial thickness and pattern by ultrasonography. This study was performed to evaluate the overall effect of endometrial thickness on pregnancy rate, multiple pregnancy rate and miscarriage rate in infertile women undergoing Intracytoplasmic Sperm Injection (ICSI) cycles … …American Journal of Applied Sciences, Vol. 9, Issue 4 · 13 Feb 2012 · 7,713 accessesView PDFCite
Research ArticleOpen accessIn the abstractTransformation of Lesquerella Fendleri with the New Binary Vector pGPro4-35SGrace Q. Chen, Roger Thilmony, Jiann-Tsyh LinProblem statement: Crop genetic engineering requires the use of various promoters to control the expression of introduced transgenes. Some of the binary vectors currently available for promoter characterization in dicotyledonous plants have pitfalls due to their construction, such as containing a selectable marker cassette with enhancer sequences that can potentially interfere with the expression specificity of nearby promoters. Also, many … …OnLine Journal of Biological Sciences, Vol. 11, Issue 3 · 19 Jan 2012 · 7,428 accessesView PDFCite
Research ArticleOpen accessIn the abstractExtra-Bone Marrow Sites of Haemopoeisis: Dihydroartemisinin Effects in Wistar Albino RatsNedosa Uchechukwu Anastasia, Saleh Mohammed, Nedosa Kenechi Stanislaus et al.Problem statement: Iron is present in ferritin, the storage form of iron in the tissues; in the respiratory cytochrome enzymes; in hemoglobin of the blood and in the myoglobin of muscle Dihydroartemisinin (DHA) has been shown to interact with heme groups in vivo and in vitro. This study investigated the effects of 5 day and 7day oral dihydroartemisinin treatments on … …American Journal of Applied Sciences, Vol. 9, Issue 1 · 2 Nov 2011 · 6,828 accessesView PDFCite
Research ArticleOpen accessIn the abstractAntibacterial Activity of β-Cyclodextrin and 2-Hydroxypropyl-β-Cyclodextrin Trimethoprim ComplexesHsien-Kuo Sun, Madhumathi Seshadri, Scott Lingard et al.Problem statement: Cyclodextrin complexation has previously been shown to improve the solubility and dissolution properties of trimethoprim; however, no report provides an account of the effect cyclodextrin complexation has on the antibacterial activity of this agent. Approach: β-cyclodextrin and 2-hydroxypropyl β-cyclodextrin inclusion complexes of trimethoprim were prepared and confirmed by differential scanning calorimetry and proton nuclear magnetic resonance. The in-vitro … …Current Research in Microbiology, Vol. 2, Issue 1 · 26 Oct 2011 · 14,806 accessesView PDFCite
Research ArticleOpen accessIn the abstractGrowth Enhancement and Disease Reduction of Soybean by 1-Aminocyclopropane-1-Carboxylate Deaminase-Producing PseudomonasEdi Husen, Aris Tri Wahyudi, Antonius Suwanto, GiyantoProblem statement: 1-Aminocyclopropane-1-Carboxylate (ACC) deaminase-producing bacteria have been known to ameliorate the inhibition-effect of increase concentration of ethylene in higher plants, which can be triggered by high concentration of indole-3-Acetic Acid (IAA) and/or by the presence of plant pathogens. This study examined the potential use of Pseudomonas isolates producing ACC deaminase as well as IAA to enhance soybean growth and … …American Journal of Applied Sciences, Vol. 8, Issue 11 · 23 Sep 2011 · 7,914 accessesView PDFCite
Research ArticleOpen accessIn the abstractAnticancer Activity of Some New Synthesized Tetrahydroquinoline and Tetrahydrochromene Carbonitrile DerivativesUsama W. Hawas, Mohamed A. Al-Omar, Abd El-Galil E. Amr, Abu El-Ftouh G. HammamProblem statement: In continuation to our search for new heterocyclic chemistry based anticancer, the suggestion, synthesis, structure elucidation of some naphthalene, chromene and quinoline derivatives 3-7 were realized herein using 3-methylcyclohexanone 1 as a starting material. Approach: The antitumor activities of the newly synthesized compounds 4-7 were evaluated utilizing 60 different human tumor cell lines, representing leukemia, melanoma, lung, colon, … …American Journal of Applied Sciences, Vol. 8, Issue 10 · 14 Sep 2011 · 7,487 accessesView PDFCite
Research ArticleOpen accessIn the abstractPalmitate-Induced Translocation of Caveolin-3 and Endothelial Nitric Oxide Synthase in CardiomyocytesCatherine J. Knowles, Megan Dionne, Martina Cebova, Ilka M. PinzProblem statement: Palmitate is a known cardiac lipotoxin that blunts cardiomyocyte contractile function and induces apoptosis, likely via accumulation of the lipotoxic ceramide. Ceramide is a sphingolipid and localizes to caveolae, which are lined in the inner membrane leaflet by caveolin proteins. In this study, we investigated the effects of palmitate on caveolin proteins and on endothelial Nitric Oxide Synthase … …OnLine Journal of Biological Sciences, Vol. 11, Issue 2 · 27 Aug 2011 · 7,897 accessesView PDFCite
Research ArticleOpen accessIn the abstractAnticancer Activities of Some New Synthesized Thiazolo[3,2-a]Pyrido[4,3-d]Pyrimidine DerivativesAshraf M. Mohamed, Abdel-Galil E. Amr, Musaed A. Alsharari et al.Problem statement: This study describes the synthesis and anticancer activities of a new series of thiazolo[3,2-a]pyrimidines derivatives (2-7) using 3,5-bisarylmethylene-1-methyl-4- piperidone and 4-aryl-8-arylmethelene-6-methylpyrido[4,3-d]pyrimidine-2(1H)thiones as a starting materials. Approach: The antitumor activities of the newly synthesized compounds 4-7 were evaluated utilizing 60 different human tumor cell lines, representing leukemia, melanoma, lung, colon, brain, ovary, breast and prostate as well as kidney. … …American Journal of Biochemistry and Biotechnology, Vol. 7, Issue 2 · 23 Aug 2011 · 10,093 accessesView PDFCite