Research ArticleOpen accessAll words, across the recordThe Arid3a Transcription Factor Rescues Natural and RAS-V12-Induced Senescence Via a Rb-Dependent PathwayChristian Schmidt, Dongkyoon Kim, Shawn Mathur et al.Primary cells are protected against oncogenic events by undergoing premature cellular senescence—an irreversible cell cycle arrest activated by mitogenic signaling as well as by overexpression of tumor suppressors, including p16INK4A, p53 and PML. In the human, downregulation of Dril1/E2F-BP1, a transcriptional regulator of E2F, promotes PML-dependent premature senescence and bypass of ant-iproliferative signaling by p19Arf/p53/p21Cip1 and p16INK4a to prevent both … …American Journal of Immunology, Vol. 13, Issue 4 · 4 Nov 2017 · 8,396 accessesView PDFCite
Research ArticleOpen accessAll words, across the recordCrack Growth in Concrete Gravity Dams Based on Discrete Crack MethodA.R. Lohrasbi, R. AttarnejadSeepage is the most parameter in water management safety and in stable agricultural. This seepage is passed through the cracks that are present to some degree in hydraulic structures. They may exist as basic defects in the constituent materials or may be induced in construction or during service life. To avoid such failure in concrete dams, safety would be an … …American Journal of Engineering and Applied Sciences, Vol. 1, Issue 4 · 31 Dec 2008 · 7,078 accessesView PDFCite
Research ArticleOpen accessAll words, across the recordThe Proteolytic System of Candida dubliniensisLoaiza-Loeza Salomé, Parra-Ortega Berenice, Bautista-Muñoz Consuelo et al.Proteases of Candida dubliniensis have been scarcely studied, these enzymes may play an important role in nitrogen metabolism, post-translational processing, nutritional stress, dimorphism, virulence, etc. In this work, we report the presence of five different intracellular proteases and one extracellular proteolytic activity. The intracellular proteases are: aminopeptidase ycdAPE, carboxypeptidase ycdCP, dipeptidyl aminopeptidase ycdDAP, proteinases ycdPrA and ycdPrB, and extracellular protease … …American Journal of Infectious Diseases, Vol. 3, Issue 2 · 30 Jun 2007 · 6,953 accessesView PDFCite
Research ArticleOpen accessAll words, across the recordThe Effect of RSA Exponential Key Growth on the Multi-Core Computational ResourceMohamad A. Mohamed, Ammar Y. Tuama, Mokhairi Makhtar et al.Cryptography has been widely used as a mean to secure message communication. A cryptosystem is made up of a publicly available algorithm and a secretly kept key. The algorithm is responsible for transforming the original message into something unintelligible. The result of losing the key or cracked algorithm can be catastrophic, where all secret communications will be known to adversaries. … …American Journal of Engineering and Applied Sciences, Vol. 9, Issue 4 · 25 Nov 2016 · 7,827 accessesView PDFCite
Research ArticleOpen accessAll words, across the recordFactors Affecting the Geometry of Silver Nanoparticles Synthesis in Chrysosporium Tropicum and Fusarium OxysporumNamita Soni, Soam PrakashProblem statement: Biosynthesis of nanoparticles using fungal cells is a novel approach to develop biotechnological possess such as bioleaching and bioremediation. In the present study, an effort was made to investigate the effect of physio-chemical parameters on the silver nanoparticle formation with the fungus Chrysosporium tropicum Carmichael and Fusarium oxysporum Schltdl. Approach: The possibilities to manipulating the geometry of silver … …Current Research in Nanotechnology, Vol. 2, Issue 1 · 20 Jan 2012 · 19,454 accessesView PDFCite
Research ArticleOpen accessAll words, across the recordThe Role of Home Stay for Ecotourism Development in East Coast Economic RegionMd. Anowar Hossain Bhuiyan, Chamhuri Siwar, Shaharuddin Mohamad Ismail, Rabiul IslamProblem statement: This study provided a brief discussion of home stay for ecotourism development in ECER. Home stay is a potential economic activity in tourism sector. The East Coast Economic Region (ECER) has numerous ecotourism resources including hills, mountains, lakes, waterways, state and national parks, recreational forest parks and forest reserves. Home stay should emphasize on the cultural practices as … …American Journal of Applied Sciences, Vol. 8, Issue 6 · 13 Jun 2011 · 9,860 accessesView PDFCite