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291 articles for “PCR”
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Research ArticleOpen accessIn the abstractMicrobial Biodiversity Screening for Metal Accumulators from Mineral Ore Rich Site in Andhra Pradesh, IndiaAditya Kumar Sarkar, Susmita Roy, Ananya Pal et al.Problem statement: Since the site selected for screening was a source of magnetite, the objective of this study was to isolate some groups of magnetotactic bacteria and microbes with potential of metal accumulation. Approach: The culture based approach was used for the study. Pure isolates obtained were characterized on the basis of morphology, biochemical tests, physiology as well as at … …OnLine Journal of Biological Sciences, Vol. 8, Issue 2 · 30 Jun 2008 · 7,553 accessesView PDFCite
Research ArticleOpen accessIn the abstractDengue Virus Infection Induced NF-κB-dependent Macrophage Migration Inhibitory Factor ProductionLien-Cheng Chen, Huey-Wen Shyu, Huan-Yao Lei et al.Dengue virus (DV) infection can cause mild dengue fever or severe dengue hemorrhage fever and dengue shock syndrome. Macrophage migration inhibitory factor (MIF) is a cytokine that plays an important role in the modulation of inflammatory and immune responses and serum levels of MIF are correlated with disease severity in dengue patients. However, the mechanism that induces MIF production during … …American Journal of Infectious Diseases, Vol. 4, Issue 1 · 31 Mar 2008 · 7,293 accessesView PDFCite
Research ArticleOpen accessIn the abstractMutations in Tumor suppressor TP53 Gene in Formalin- Fixed, Paraffin Embedded Tissues of Squamous Cell Carcinoma (SCC) of Lung CancerAbbas Mohammadi, Ali Vaziri Gohar, Mohamad Reza ShakibaieThe TP53 gene mutations have been extensively studied in lung cancer and have been used as a means to understand the origin(s) and mechanisms of these mutations in lung cancer development. TP53 gene mutations occur frequently in many human cancers. Analysis of TP53 gene mutations can also provide clues to the etiology of tumor formation. Formalin-fixed, paraffin embedded (FFPE) tissues … …American Journal of Biochemistry and Biotechnology, Vol. 4, Issue 1 · 31 Mar 2008 · 8,006 accessesView PDFCite
Research ArticleOpen accessIn the abstractRat Cardiomyocytes Express a Classical Epithelial Beta-DefensinAnnika Linde, Gerald H. Lushington, Frank Blecha, Tonatiuh MelgarejoBeta-defensins (BDs) are classical epithelial antimicrobial peptides of immediate importance in innate host defense. Since recent studies have suggested that certain BDs are also expressed in non-traditional tissues, including whole heart homogenate, and because effector molecules of innate immunity and inflammation can influence the development of certain cardiovascular disease processes, we hypothesized that BDs are produced by cardiomyocytes as a … …American Journal of Animal and Veterinary Sciences, Vol. 3, Issue 1 · 31 Mar 2008 · 7,000 accessesView PDFCite
Research ArticleOpen accessIn the abstractTherapeutic Effects of Phyllanthus Species: Induction of TNF-α-mediated Apoptosis in HepG2 Hepatocellular Carcinoma CellsSripathi M. Sureban, Dharmalingam Subramaniam, Paramasivam Rajendran et al.Phyllanthus species, especially P. amarus is a medicinal plant with hepatoprotective activity, believed to occur in part by inhibiting hepatitis B virus function. The pathogenesis mechanism of viral hepatitis is closely related to hepatocyte necrosis apoptosis. The aim of our study was to investigate the in vitro effects of extracts from three Phyllanthus species, P. urinaria, P. amarus and P. … …American Journal of Pharmacology and Toxicology, Vol. 1, Issue 4 · 31 Dec 2007 · 9,009 accessesView PDFCite
Research ArticleOpen accessIn the abstractHIV-1 Infection and Central Monoamine NeurotransmittersAdarsh M. Kumar, J. B. Fernandez, Irina Borodowsky et al.Human immunodeficiency virus type 1 (HIV-1) enters the central nervous system (CNS) shortly after infection and gets localized in different brain regions, leading to various types of neuropathological problems. It has been hypothesized that HIV-1 infection mediated neuropathogenesis may also adversely affect the activity of the central monoamine neurotransmitters systems, such as dopamine (DA), and 5-hydroxytryptamine (5-HT, serotonin), resulting in … …American Journal of Infectious Diseases, Vol. 3, Issue 4 · 31 Dec 2007 · 7,493 accessesView PDFCite
Research ArticleOpen accessIn the abstractPrevalence of Herpesvirus 8 Infection in Type 2 Diabetes Mellitus PatientsA. Ingianni, F. Carta, A. Reina et al.In this study a possible relationship between the presence of type 2 diabetes (DM2) and the Human Herpesvirus 8 infection (HHV-8) has been evaluated. The presence of HHV-8 DNA was monitored by nested PCR and Southern blotting in peripheral blood leucocytes of DM2 patients admitted to the Diabetology and Metabolic Disease Service of the "S. Giovanni di Dio" Hospital (Cagliari, … …American Journal of Infectious Diseases, Vol. 3, Issue 3 · 30 Sep 2007 · 7,927 accessesView PDFCite
Research ArticleOpen accessIn the abstractExpression of Toll-like Receptors (TLRs) and Nucleotide-binding Oligomerization Domain (NODs) in murine peritoneal macrophages on in vitro treatment with Thymosin α 1Shikha Tarang, Ajit SodhiThymosin α 1 (Tα1) treatment of murine peritoneal macrophages in vitro induces the expression of TLRs and Nod2 proteins. Enhanced expressions of TLR2, -4, -5, -6, -7, -8, -9 and Nod2 were observed by RT-PCR and western blotting. Expression of downstream signaling molecules - MyD88, IRAK1, TRAF6, IRF3 were also up regulated on treatment with Tα1. It was also observed … …American Journal of Immunology, Vol. 3, Issue 1 · 30 Jun 2007 · 7,154 accessesView PDFCite
Research ArticleOpen accessIn the abstractNew Bacterial Species Isolated from Malaysian Sea Cucumbers with Optimized Secreted Antibacterial ActivityAbd El-Aziem Farouk, Faizal Abd. Hamid Ghouse, B.H. RidzwanIn this study, several Malaysian sea cucumber species that have traditional medicine value were selected and from them, the native bacterial population was isolated. Optimization of growth was designed and all bacterial secretions were tested for antibacterial properties. 30 bacterial types were isolated and 7 types recorded moderate antibacterial activity against K. pneumoniae, S. marscens, P. aeruginosa and E. feacalis. … …American Journal of Biochemistry and Biotechnology, Vol. 3, Issue 2 · 30 Jun 2007 · 8,847 accessesView PDFCite
Research ArticleOpen accessIn the abstractAssociation of DNA Polymorphism at the Apolipoprotein B-100 Gene Locus with Plasma Lipid Concentration and Coronary Artery Disease among North IndiansVivek Pratap Singh, V. Ramesh, Sonal Somvanshi et al.The aim of this study was to investigate the association between apolipoprotein B gene polymorphisms and coronary artery disease and lipid levels in north Indians. Two hundred patients of angiographically proven atherosclerotic CAD and two hundred age and sex matched control subjects were included in the study. Serum lipids including cholesterol, triglycerides, HDL, LDL, VLDL and ApoB were analyzed. PCR … …American Journal of Biochemistry and Biotechnology, Vol. 2, Issue 4 · 31 Dec 2006 · 7,896 accessesView PDFCite