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Research ArticleOpen accessIn the abstractCarica papaya Fruit Attenuates Apoptotic Degeneration After Permanent Cerebral Ischemia RatPratchaya KaewkaenApoptotic neurodegeneration is a phenomenon following cerebral ischemia. Both the increased caspase-3 and decreased Bcl-2 expression are reported to play crucial role on apoptosis in neuron. In addition, phytonutrient can successfully increase the endogenous antioxidant and lower the apoptotic responses. Therefore, anti-apoptotic effect of Carica papaya fruits was examined. To the best of our knowledge, no scientific effect was available. … …American Journal of Biochemistry and Biotechnology, Vol. 14, Issue 4 · 22 Nov 2018 · 9,790 accessesView PDFCite
InvestigationOpen accessIn the abstractDevelopment of Genetic Constructions for Exctocytosis ControlIrina Nikolaevna Dominova, Vitaly Anvarovich Kasymov, Ekaterina Vladimirovna Silina et al.A fragment of the research project devoted to the development of genetic control of exocytosis is presented in the work, which can further ensure the success of targeted therapy of various diseases, including neurodegenerative ones. For the purpose of specific transfection of intracellular cascades in astrocytes in vivo, we have developed an experimental sample of the reagent kit. The latter … …OnLine Journal of Biological Sciences, Vol. 18, Issue 2 · 29 Jan 2018 · 7,310 accessesView PDFCite
Research ArticleOpen accessIn the abstractAnalgesic and Anti-inflammatory Activity of Euphorbia antiquorum LinnBanibrata Das, Samina Alam, Rajib Bhattacharjee, Biplab Kumar DasEuphorbia antiquorum (L.) is used as traditional medicine for various ailments in Bangladesh. But the scientific basis for its use especially in pain and inflammation remains largely unknown. Therefore, the present study was designed to evaluate analgesic and anti-inflammatory effect of the aqueous ethanolic extract of the whole plant. The analgesic activity was evaluated by hot plate, acetic acid induced … …American Journal of Pharmacology and Toxicology, Vol. 10, Issue 2 · 27 Aug 2015 · 9,211 accessesView PDFCite
EditorialOpen accessIn the abstractAMYOTROPHIC LATERAL SCLEROSIS: HOW TO UNDERSTAND SUCH DIVERSE AND SO ENTANGLED PHYSIOPATHOLOGY?Carlos Henrique Melo Reis, Marco Orsini, Marco Antônio Araujo Leite et al.When in 1865, JeanMartin Charcotreported patients with progressive muscular atrophysuperimposedwith spasticity of inexorable evolution as result of combinedlesions of the anterior horn and lateral column of the spinal cord, hecertainly inaugurated an attempt on the comprehension of one of the mostcomplexes neurological clinical conditions, which until today persists withimmense voids on their comprehension, regardless of the enormous advancesachieved. Astime went … …Current Research in Medicine, Vol. 5, Issue 2 · 16 Feb 2015 · 7,149 accessesView PDFCite
Research ArticleOpen accessIn the abstractAnti-Inflammatory, Analgesic and Antioxidant Activities of Allophylus Cobbe LeavesPreeti Jain, Md. Selim Hossain, Kaniz Fatema et al.Allophylus cobbe L. Raeuschel (Family-Sapindaceae) is a medicinal plant used traditionally for the treatment of various health risks like pain, inflammation, ulcers and wounds in Bangladesh. This study determined the polyphenolic compounds and evaluated the analgesic, anti-inflammatory and antioxidant effects of the ethanol extract of Allophylus cobbe leaves. High Performance Liquid Chromatography (HPLC) analysis was used to determine the polyphenolic … …American Journal of Pharmacology and Toxicology, Vol. 9, Issue 4 · 27 Jan 2015 · 8,152 accessesView PDFCite
Research ArticleOpen accessIn the abstractCOMPARATIVE STUDY OF ANTIBACTERIAL ACTIVITY OF PLANT EXTRACTS FROM SEVERAL REGIONS OF ASIAAwatif Al-Judaibi, Ashwag Al-Zahrani, Khadijah A. Altammar et al.This study was designed to investigate the antibacterial activities of alcohol extracts of Phoenix dactylifera (date palm ’type Ajwa’), Nigella sativa (black cumin), Elettaria cardamomum (cardamom), Tinospora crispa (Akar patawali) and Panax ginseng (ginseng). The plant extracts were prepared with methanol and assayed for antibacterial activity against Methicillin-Resistant Staphylococcus Aureus (MRSA) and S. aureus. Extracts of N. sativa, E. cardamomum … …American Journal of Pharmacology and Toxicology, Vol. 9, Issue 2 · 2 Apr 2014 · 7,569 accessesView PDFCite
Research ArticleOpen accessIn the abstractCastration and Passive Avoidance Learning Alter the Distribution of N-Methyl D-Aspartate ReceptorSeyed Hassan Mirzaei, Mahnaz Taherianfard, Mina Tadjali, Mahbobeh KohkaloyehIn neurophysiological studies on learning and memory, L-glutamate receptors especially N-Methyl, D-Aspartate glutamate (NMDA) receptors have a major role in different aspect of the learning and memory. Two sites of mammalian brain that show high density of these receptors are CA1 region of hippocampus and Purkinje cell layer of cerebellum. Twenty four Sprague-Dawley rats were used in 4 groups: Control … …Neuroscience International, Vol. 4, Issue 2 · 1 Apr 2014 · 6,773 accessesView PDFCite
Research ArticleOpen accessIn the abstractSelenium Effect on Hyperoxia-Induced Glutathione Peroxidase Activity and Free Radicals Production in the BrainIsmaeel Bin-JaliahThe purpose of this study was to examine the behavior of Glutathione Peroxidase (GPx) activity and Free Radicals (FR) production in the brain during graded hyperoxia exposure with and without selenium preventive intake. Forty two adult male rats were assigned to seven groups, six animals each. The first group served as control and the second, third and fourth groups were … …American Journal of Environmental Sciences, Vol. 9, Issue 5 · 7 Dec 2013 · 6,745 accessesView PDFCite
Research ArticleOpen accessIn the abstractEffects of Gc-Macrophage Activating Factor in Human Neurons; Implications for Treatment of Chronic Fatigue SyndromeRodney Smith, Lynda Thyer, Emma Ward et al.Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a debilitating disease of multifactorial aetiology characterized by immune system dysfunction, widespread inflammation, multisystemic neuropathology and persistent pain. Given the central role of the immune system in the pathogenesis of the syndrome, we studied the effects of a potent modulator of the immune system in in vitro and in vivo models that could help … …American Journal of Immunology, Vol. 9, Issue 4 · 6 Nov 2013 · 10,982 accessesView PDFCite
Research ArticleOpen accessIn the abstractElectromagnetic Field and Γ Aminobutyric Acid a Receptors Interaction in the Fear ResponseM. Taherianfard, A. Bahaodini, M. Fazeli et al.Freezing behavior is a fearful reaction to specific stimuli, most commonly observed by animals. One of the neurotransmission system most consistently linked with fear response is the GABAergic system, in which GABA through GABAA receptor can influence fear response. The aim of the present investigation was to examine the effect of IP injection of muscimol (GABAA agonist) and bicuculline (GABAA … …Current Research in Psychology, Vol. 4, Issue 1 · 4 Sep 2013 · 7,515 accessesView PDFCite