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Research ArticleOpen accessPhrase in the titleSafety Assessment of Herbal Formulations, Rumbion™ and Tyrel™ in Albino Wistar RatsA.J. Joshua, K.S. Goudar, N. Sameera et al.Problem statement: Herbal remedies form one of the effective strategies for management of livestock healthcare. Despite the availability of extensive pharmacological information, the toxicological data on herbs and herbal preparations seem to be scanty. The objective of the present investigation was to evaluate the acute oral toxicity of some herbal veterinary preparations in albino Wistar rats. Approach: In the sighting … …American Journal of Pharmacology and Toxicology, Vol. 5, Issue 1 · 31 Mar 2010 · 8,544 accessesView PDFCite
Research ArticleOpen accessPhrase in the titleBiochemical Changes in Wistar Rats on Oral Doses of Mistletoe (Loranthus micranthus)D. O. Edem, I. F. UsohProblem statement: To evaluate the effects of the water extract of the leaves of mistletoe (Loranthus micranthus) (traditionally used antidiabetic and antihypertensive) in male albino Wistar rats. Approach: The animals were divided into 4 groups (n = 6). Water extract of L. micranthus leaves was administered in graded doses of 0, 275, 551 and 827 mg kg-1 body weight (wt) … …American Journal of Pharmacology and Toxicology, Vol. 4, Issue 3 · 30 Sep 2009 · 8,539 accessesView PDFCite
Research ArticleOpen accessPhrase in the titleAlcohol Intubation and Synergistic Effect of Folic Acid and Egg Yolk Powder Solution on Alcohol Dehydrogenase [ADH] Class I Gene Expression and Single Nucleotide Polymorphism Frequency in Parent and Prenatal Alcohol Exposed Wistar RatsAdejoke Olukayode Obajuluwa, Oluyinka Ajibola Iyiola, Joseph Akintade Morakinyo et al.Point mutation detections in alcohol metabolizing genes could unravel molecular targets of gestational alcohol and epigenetic remodeling capacity of maternal nutrition, which underscores growth and health endpoints in Pre­natal Alcohol Exposed (PAE) fetuses. gene expression was assayed using sequenced target and internal control gene primers in a two-step thermal cycling process from isolated RNA in purely bred alcohol male and … …OnLine Journal of Biological Sciences, Vol. 24, Issue 1 · 22 Nov 2023 · 4,857 accessesView PDFCite
Research ArticleOpen accessPhrase in the titleInfluence of Helium-Neon Laser Photostimulation on Excision Wound Healing in Wistar RatsB. S. Nayak, A. Maiya, P. KumarThe importance of laser photostimulation is now accepted generally but the laser light facilitates wound healing and tissue repair remains poorly understood. So we have examined the hypothesis that the laser photo stimulation can enhances the collagen production in excision wounds using excision wound model in Wister rat model. The circular wounds were created on the dorsum of the back … …OnLine Journal of Biological Sciences, Vol. 7, Issue 2 · 31 Dec 2007 · 7,376 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleErythropoietin-Like Effects of Dihydroartemisinin in Wistar Albino RatsUtoh-Nedosa Uchechukwu Anastasia, Nedosa Kenechi Stanislaus, Onyedibe Ikenna KennethArtemisinin drugs were active during the intra-erythrocytic stage of malaria parasite infection. The activity of artemisinin and synthetic endoperoxides was related to their interaction with heme. The electrophillic intermediate formed from artemisinin in the presence of heme alkylates the protein portion of hemoglobin preferentially to the heme portion. Problem statement: Since there might be an interaction between artemisinin and the … …American Journal of Agricultural and Biological Sciences, Vol. 6, Issue 4 · 9 Dec 2011 · 7,785 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleExtra-Bone Marrow Sites of Haemopoeisis: Dihydroartemisinin Effects in Wistar Albino RatsNedosa Uchechukwu Anastasia, Saleh Mohammed, Nedosa Kenechi Stanislaus et al.Problem statement: Iron is present in ferritin, the storage form of iron in the tissues; in the respiratory cytochrome enzymes; in hemoglobin of the blood and in the myoglobin of muscle Dihydroartemisinin (DHA) has been shown to interact with heme groups in vivo and in vitro. This study investigated the effects of 5 day and 7day oral dihydroartemisinin treatments on … …American Journal of Applied Sciences, Vol. 9, Issue 1 · 2 Nov 2011 · 6,826 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleModulatory Effects of Bryophyllum Pinnatum Leaves Extract on Peroxidation Indices of CCl4 Induced-Hepatotoxicity in Wistar Albino RatsChioma Assumpta Anosike, Sophia Uyo Mokwunye, Victor Eshu Okpashi, Obiorah AbonyiThis research investigated the modulatory effect of methanol extract of Bryophyllum pinnatum leaves on peroxidation indices of CCl4-induced hepatotoxicity. Thirty rats of average weight 150g divided into six groups of 5 rats each were used for the study. Group one (control) received water and paraffin for ten days. Group two (treatment control) received water only, group 3 (standard control), received … …American Journal of Pharmacology and Toxicology, Vol. 12, Issue 3 · 17 Dec 2017 · 7,448 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleRespiratory Tract-Widening Effects of Dihydroartemisinin in Wistar Albino RatsUtoh-Nedosa Uchechukwu, Njoku Goddy, S. Nedosa Kenechi et al.Problem statement: Artemisinin-based anti-malarials are currently widely used in Asia and Africa. Not much is known about the systemic effect of dihydroartemisinin. This study therefore examine the effect of dihydroartemisinin on the lungs of Wistar albino rats. Approach: Five dosages of Dihydroartemisinin (DHA) were administered by oral intubation for 5 days to 5 test and 4 control Wistar albino rats. … …American Journal of Pharmacology and Toxicology, Vol. 6, Issue 2 · 17 Aug 2011 · 7,515 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleMELATONIN PROTECTS THE INTEGRITY OF GASTRIC STRUCTURE FROM A STERILE TISSUE INJURY AND AUGMENTS BOTH MONONUCLEAR AND POLYMORPHONUCLEAR PERIPHERAL BLOOD CELLS INDUCED BY THE INJURY IN WISTAR ALBINO RATSBahjat Al-AniPeptic ulcer is a common upper gastrointestinal disease that remains a major public health problem. Gastric ulceration caused by Nonsteroidal Anti-Inflammatory Drugs (NSAID), stress and alcohol are the common causes of gastric ulcer formation in humans following helicobacter pylori bacterial infection of the stomach. The neurohormone, melatonin was reported to protect against NSAID- and stress-induced gastric lesions. We sought to … …American Journal of Pharmacology and Toxicology, Vol. 9, Issue 2 · 17 Mar 2014 · 7,227 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleStimulatory Effects of Dihydroartemisinin on the Leucocyte Population of Wistar Albino RatsU. A. Utoh-Nedosa, P. A. Akah, C. O. Okoli et al.Problem statement: Five dosages of Dihydroartemisinin (DHA) which included 1 mg kg-1; a repeated dose of 1; 2; 60 and 80 mg kg-1 were administered orally to albino rats for 5 days. The results of the study showed that dihydroartemisinin treatment significantly elevated the total white cell count (p<0.01); the percentage neutrophil count (p<0.01) and the percentage lymphocyte count (p<0.05). … …American Journal of Infectious Diseases, Vol. 7, Issue 3 · 17 Nov 2011 · 7,350 accessesView PDFCite