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24 results for “tumor marker”
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Research ArticleOpen accessIn the abstractEvaluating the Hepatoprotective and Anti-Inflammatory Efficacy of Herbal Extracts for NAFLD PreventionHessah Mohammed Al-Muzafar, Kamal Adel AminNatural products may offer a safer approach for mitigating the increasing prevalence of Non-Alcoholic Fatty Liver Disease (NAFLD). This study aimed to evaluate the hepatoprotective and anti-inflammatory effects of a water-based extract of Moringa Oleifera leaf, Milk Thistle, and Cassia (MO-MT-CA) against High-Fat, High-Sugar Diet (HFSD)-induced fatty liver. The research focuses on assessing lipid profiles and inflammation as key markers … …OnLine Journal of Biological Sciences, Vol. 25, Issue 3 · 23 Nov 2025 · 1,968 accessesView PDFCite
Research ArticleOpen accessIn the abstractEvaluation of Serum Interleukin-8 (CXCL8) Concentrations in Tumor Bearing DogsMelanie Haas, Franz-Josef Kaup, Stephan NeumannInterleukin-8 (IL-8 or CXCL8) is a pro-inflammatory and angiogenic chemokine involved in tumorigenesis. Serum CXCL8 is elevated in various neoplastic diseases, but its potential value as a tumor marker in veterinary medicine is unknown. Here, we measured serum CXCL8 concentrations in dogs with various neoplastic diseases using a commercially available canine ELISA kit and analyzed its relationship with patient and … …American Journal of Animal and Veterinary Sciences, Vol. 10, Issue 4 · 24 Nov 2015 · 6,975 accessesView PDFCite
EditorialOpen accessIn the abstractAre we Able to Harness the Immunomodulatory Power of Cytokines for Novel Autoimmune Disease Treatments?Giuseppe Nocentini, Graziella Migliorati, Carlo RiccardiSince the end of the 1970s, interleukin 2 (IL-2) has been known as a key player in T cell expansion/activation (Watson et al., 1980). In the late 1980s, some groups used IL-2 to stimulate the immune systems of tumour patients (Jacobs et al., 1986). The idea seemed brilliant and several attempts were made, but the results were disappointing (Lim et … …American Journal of Pharmacology and Toxicology, Vol. 10, Issue 2 · 22 Oct 2015 · 7,625 accessesView PDFCite
Research ArticleOpen accessIn the abstractTHE IMPACT OF ANTIOXIDANTS ON INFLAMMATION AND OXIDATIVE STRESS MARKERS IN OSTEOARTHRITIS RAT MODEL: SCANNING ELECTRON MICROSCOPE INSIGHTSEl Hassan Heidar, FareedF Al Faya, Waleed N. Hassan et al.Osteoarthritis (OA) is characterized by degradation of matrix and destruction of articular cartilage. Articular chondrocytes are solely responsible for the production and maintenance of the extracellular matrix. Therefore, chondrocyte disruption is implicated in cartilage degeneration. Numerous studies have shown that antioxidant treatments are promising therapeutics in cases of OA. This study was designedto examine whether vitamin E protects rat articular … …American Journal of Pharmacology and Toxicology, Vol. 9, Issue 2 · 19 May 2014 · 7,616 accessesView PDFCite
Research ArticleOpen accessIn the abstractP53 Gene: Mutation and Immunohistochemical Analysis in Patients with Invasive Ductal Carcinoma of BreastShinjini Singh, Sandeep Kumar Rajput, Mritunjai Singh et al.The p53 tumor suppressor gene is the most commonly mutated gene in cancer. In breast cancer, the presence of p53 gene alterations has been associated with worse prognosis. This study was attempted to associate p53 gene mutations with its protein expression in North Eastern Indian population. We used single-stranded conformation polymorphism to screen samples for mutations in five conserved regions, … …American Journal of Biochemistry and Biotechnology, Vol. 9, Issue 4 · 20 Dec 2013 · 7,244 accessesView PDFCite
Research ArticleOpen accessIn the abstractIMMUNOHISTOCHEMICAL ANALYSIS OF UROTHELIAL BLADDER CANCERSKatarina Bevizova, Jan Jakubovsky, Jan Luha et al.Malignant cancers of urinary bladder are the second most common malignancy of the urinary tract and the fourth most common malignancy in general, especially in men. The aim of this study was a retrospective analysis of selected markers (p53, Ki-67 and E-cadherin) of urinary bladder cancers from the Department of Urology in Bratislava, Slovak Republic between years 2007 and 2009. … …OnLine Journal of Biological Sciences, Vol. 13, Issue 2 · 17 Jul 2013 · 7,372 accessesView PDFCite
Research ArticleOpen accessIn the abstractRole of Progranulin Gene Expression as a Molecular Biomarker for Bladder CancerSalwa M. Abo El-khair, Mie A. Mohamed, Tamer E. AlkhiaryBladder cancer is the second most common cancer of the urinary system. Early diagnosis of this tumor and estimation of risk of future progression has a significant impact on prognosis. Although there are several molecular markers for the diagnosis and prognosis for this tumor, their accuracy is not ideal. Progranulin is a growth factor that may play a critical role … …American Journal of Biochemistry and Biotechnology, Vol. 8, Issue 2 · 22 Jun 2012 · 7,699 accessesView PDFCite
Research ArticleOpen accessIn the abstractClinical Evidence of Autologous Graft versus Tumor EffectLuis F. PorrataProblem statement: The infused alloreactive lymphocytes in allogeneic stem cell transplantation (Allo-SCT) lead to an unspecific immune response causing Graft-Versus-Tumor (GVT) effect and Graft-Versus-Host Disease (GVHD). The current dogma regarding the anti-tumor effect of GVT is only observed in the Allo-SCT and not in the autologous hematopoietic stem cell transplantation (AHSCT). Approach: This article reviewed the medical literature to show … …American Journal of Immunology, Vol. 5, Issue 1 · 31 Jan 2009 · 7,506 accessesView PDFCite
Research ArticleOpen accessIn the abstractCorrelation between Tissue and Released VEGF Levels in Urine of Bladder Cancer PatientsMenha Swellam, Abdulla A.A. El-AalPurpose. Angiogenesis is a complex multistep process essential for tumor growth. Vascular endothelial growth factor (VEGF) is a potent endothelial cell mitogen and vascular permeability-inducing agent. The aim of this study was to analyze whether tissue and urinary VEGF levels of bladder cancer patients are correlated and study their correlation with classical clinicopathological parameters and bilharizial bladder cancer patients. The … …American Journal of Biochemistry and Biotechnology, Vol. 1, Issue 1 · 31 Mar 2005 · 6,639 accessesView PDFCite
Research ArticleOpen accessIn the abstractIsolation and Identification of Oral Cancer Stem Cells (CSC) within Commercially Available Cell LinesRobert Chauncey, Kai Hatch, Toni Jilka et al.Previous studies have demonstrated some tumors develop or maintain a small sub-population of cells with stem cell-like properties. This Cancer Stem Cells (CSC) may exhibit differential properties that allow their escape from traditional radiation or chemotherapy treatments and may therefore be responsible for cancer recurrence. Few studies have explored this phenomenon among oral cancer cell lines, therefore the objective of … …Current Research in Dentistry, Vol. 9, Issue 1 · 2 Jun 2018 · 12,719 accessesView PDFCite