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62 articles for “therapeutic agent”
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Review ArticleOpen accessIn the abstractLong Way of Evaluating Niacin for Atherosclerosis TreatmentAnastasia Vladimirovna Poznyak, Victoria Alexandrovna Khotina, Elizaveta Mikhailovna Pleshko et al.Atherosclerosis is a significant public health challenge, as it is closely associated with a wide range of cardiovascular diseases and complications. Despite its grave implications, the timely detection and treatment of atherosclerosis remain complex tasks due to the intricate pathogenesis involved, which encompasses numerous processes and mechanisms. Extensive research has been conducted to investigate various therapeutic methods and drugs aimed … …OnLine Journal of Biological Sciences, Vol. 24, Issue 3 · 24 Feb 2024 · 5,122 accessesView PDFCite
Research ArticleOpen accessIn the abstractMechanism Analysis of Artemisinin and Artesunate as Lung Cancer Therapy Agents Through in Silico MethodDidik Harmoko, Vivitri Dewi Prasasty, Adi YulandiSeveral in vitro studies have focused on the ability of artemisinin and its derivatives to suppress lung cancer cells, but there are still many biological processes and mechanisms, such as the interactions between the active compounds (ligands) and receptors that are not well understood and require further research. Drug targeting for lung cancer will be more precise and the inhibition … …OnLine Journal of Biological Sciences, Vol. 24, Issue 3 · 15 Feb 2024 · 6,144 accessesView PDFCite
Review ArticleOpen accessIn the abstractPotential Effects of Adropin in Subarachnoid HemorrhageZahra Hasanpour Segherlou, Mohammad Reza Hosseini Siyanaki, Brandon Lucke-WoldSubarachnoid Hemorrhage (SAH) typically, occurs in patients over 55 years of age and can cause a significant loss of productivity. SAH also has a high mortality rate and those who survive often suffer from early and secondary brain injuries that can result from the condition. By gaining a better understanding of the pathophysiology of SAH, it may be possible to … …Neuroscience International, Vol. 13, Issue 1 · 21 Jul 2023 · 9,237 accessesView PDFCite
Review ArticleOpen accessIn the abstractMechanistic Insights of Actions of Metal Nanoparticles on Multidrug-Resistant BacteriaSeham S. Alzahrani, Hani Mohammed Ali, Mohamed M. AhmedMultidrug-Resistant bacteria (MDR) are the most serious threat to public health. The number of infections caused by resistant strains is on the rise all over the world. At this time, new techniques for developing antimicrobial drugs are becoming necessary. Metallic Nanoparticles (MNPs) in the biomedical field are one of the most promising methods to overcome antibiotic resistance. Nanoparticles have recently … …OnLine Journal of Biological Sciences, Vol. 21, Issue 2 · 22 Jun 2021 · 6,374 accessesView PDFCite
Letter to the EditorOpen accessIn the abstractSofosbuvir May be a Potential Anti-SARS-CoV-2 RdRp DrugMohamed Nabil Ibrahim, Abdo Abdellah ElfikyThe Coronavirus Diseases 2019 (COVID-19) seriously affecting human health all over the world. More than 107 M people are reported positive for SARS-CoV-2, the virus causing COVID-19 pneumonia, from which +2.3 M died. Nucleotide Inhibitors (NI) have promising results in terms of its efficacy against different viral polymerases, including the Hepatitis C Virus (HCV) Non-Structural Protein 5 B (NS5B) RNA … …American Journal of Biochemistry and Biotechnology, Vol. 17, Issue 2 · 10 May 2021 · 6,568 accessesView PDFCite
Literature ReviewOpen accessIn the abstractOzone Therapy: Overview of its Potential Utility in Male ReproductionZaher Merhi, Ali Bazzi, Rajean Moseley-LaRue et al.Ozone (O3), a highly water-soluble inorganic molecule, is a gas made of three atoms of oxygen (O) with a cyclic structure. Ozone can be produced by medical generators from pure oxygen after passing through a high voltage gradient. Ozone therapy (OT) can be given in medical practice via several routes that include transdermal, intramuscular, rectal, nasal, oral, vaginal, intravenous, intra-arterial, … …American Journal of Immunology, Vol. 14, Issue 1 · 4 Jan 2019 · 9,586 accessesView PDFCite
Literature ReviewOpen accessIn the abstractIntracranial Atherosclerotic Disease: Treatment Potential and Diagnostic OpportunitiesAnastasia Vladimirovna Poznyak, Victoria Alexandrovna Khotina, Anton Yuvenalievich Postnov et al.Atherosclerosis, characterized by the accumulation of atherosclerotic plaques within large arteries, substantially increases the risk of cardiovascular events, including ischemic stroke. Intracranial atherosclerotic disease (ICAD) represents a particularly significant clinical threat given its strong association with ischemic stroke across multiple intracranial arterial territories. This review provides a comprehensive analysis of the pathogenesis, diagnosis, and management of intracranial atherosclerosis. Special attention … …OnLine Journal of Biological Sciences, Vol. 26, Issue 1 · 5 May 2026 · 1,093 accessesView PDFCite
Review ArticleOpen accessIn the abstractAssessing Protein PurityShiva Siddappa, Liang-Yin Ke, Chu-Huang Chen, Gopal Kedihithlu MaratheDetermination of protein purity is crucial, as proteins are frequently used as therapeutic agents and reagents in many biochemical reactions. Additionally, purified protein is necessary for biophysical and structural studies. Assessing protein purity involves examining for impurities or demonstrating their absence. In our experience, a satisfactory answer is seldom obtained when biochemistry students are asked a common question on how … …American Journal of Biochemistry and Biotechnology, Vol. 21, Issue 4 · 9 Feb 2026 · 1,901 accessesView PDFCite
Research ArticleOpen accessIn the abstractMorphological Diversity of Isolated Mycobacterial Cultures in the Republic of Kazakhstan: Implications for Diagnostics and TreatmentAssiya Borsynbayeva, Kairat Turgenbayev, Gulzhauhar Sarsenova et al.The study of mycobacterial morphology in the Republic of Kazakhstan is relevant due to the increasing burden of tuberculosis and other mycobacterial diseases. The aim of this study was to comprehensively describe the morphological characteristics of different mycobacterial species identified in Kazakhstan, which will help to improve diagnostic methods and develop new approaches to treatment. Comparative and cross-cultural analyses were … …OnLine Journal of Biological Sciences, Vol. 25, Issue 4 · 1 Dec 2025 · 2,203 accessesView PDFCite
Research ArticleOpen accessIn the abstractModeling Hepatocellular Toxicity of Enavatuzumab, a Humanized Anti-TweakR AntibodyDonghee Choi, Yanhong Zhu, Debra Tien Chao et al.In a Phase 1 clinical study, treatment with enavatuzumab, a humanized monoclonal antibody to TweakR, resulted in liver toxicity in a subset of patients. The objective of this current study was to evaluate the ability of preclinical studies to predict liver toxicity in humans. Enavatuzumab was evaluated in cynomolgus monkeys, where serum liver enzyme and cytokine levels were measured and … …American Journal of Pharmacology and Toxicology, Vol. 12, Issue 2 · 9 Nov 2017 · 7,719 accessesView PDFCite