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25 results for “systemic factors”
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EditorialOpen accessIn the abstractAre we Able to Harness the Immunomodulatory Power of Cytokines for Novel Autoimmune Disease Treatments?Giuseppe Nocentini, Graziella Migliorati, Carlo RiccardiSince the end of the 1970s, interleukin 2 (IL-2) has been known as a key player in T cell expansion/activation (Watson et al., 1980). In the late 1980s, some groups used IL-2 to stimulate the immune systems of tumour patients (Jacobs et al., 1986). The idea seemed brilliant and several attempts were made, but the results were disappointing (Lim et … …American Journal of Pharmacology and Toxicology, Vol. 10, Issue 2 · 22 Oct 2015 · 7,625 accessesView PDFCite
EditorialOpen accessIn the abstractGLUTATHIONE: A POSSIBLE LINK TO AUTOPHAGY IN SYSTEMIC LUPUS ERYTHEMATOSUSDilip Shah, Swapan K. NathIncreased free radical formation and altered redox state are of fundamental importance in the pathogenesis of autoimmune diseases including Systemic Lupus Erythematos (SLE). Free radicals are mainly derived from oxygen (Reactive Oxygen Species/ROS) and nitrogen (Reactive Nitrogen Species/RNS) at mitochondria, cellular membranes and the endoplasmic reticulum membrane as physiological responses to a variety of internal and external stress (Shah et … …American Journal of Immunology, Vol. 10, Issue 3 · 3 Sep 2014 · 12,773 accessesView PDFCite
Research ArticleOpen accessIn the abstractA COMPARATIVE STUDY OF ANTI-PHOSPHATIDYL INOSITOLE ANTIBODIES IN PATIENTS WITH MYOCARDIAL INFARCTION AND HEALTHY SUBJECTSAbdolreza Sotoodeh Jahromi, Mohammad Shojaei, Fatemeh Mehdizadeh et al.Immune system and inflamation is widely known to play a key role in the development and progression of cardiovascular diseases. Anti-Phospholipid (aPL) antibodies may act in the induction of immunological response leading to the development of Acute Myocardial Infarction (AMI). Anti-Phosphatidyl Inositole (PI) Antibody (Ab) has been seen in various diseases including rheumatoid arthritis, systemic lupus erythematosus and anti-phospholipid antibody … …American Journal of Immunology, Vol. 10, Issue 1 · 23 Jan 2014 · 7,185 accessesView PDFCite
Research ArticleOpen accessIn the abstractAssociation of Anti-Phosphatidylcholine Antibodies with Acute Myocardial Infarction: A Comparative StudyAbdolreza Sotoodeh Jahromi, Mohammad Shojaei, Mohammad Reza Farjam, Abdolhossien MadaniMany factors play a role in Acute Myocardial Infarction (AMI). One those anti-Phospholipid (aPL) antibodies, that may act in the induction of immunological response leading to the development of AMI. Anti-Phosphatidylcholines (PC) antibody is detected in various diseases like rheumatoid arthritis, systemic lupus erythematosus and anti-phospholipid antibody syndrome. The study of anti-PC antibody in AMI might shed light on etiologic … …American Journal of Immunology, Vol. 9, Issue 4 · 28 Oct 2013 · 7,126 accessesView PDFCite
Research ArticleOpen accessIn the abstractAnti-Phosphatidylserine Antibodies in Acute Myocardial InfarctionAbdolreza Sotoodeh Jahromi, Mohammad Shojaei, Mohammad Reza Farjam, Abdolhossien MadaniAcute Myocardial Infarction (AMI) is the combined result of environmental factors and personal predispositions. Many factors play a role in AMI including anti-Phospholipid (aPL) antibodies, that may act in the induction of immunological response leading to the development of AMI. Anti-Phosphatidylserine (PS) antibody is detected in various diseases like rheumatoid arthritis, systemic lupus erythematosus and anti-phospholipid antibody syndrome. The study … …American Journal of Immunology, Vol. 9, Issue 4 · 21 Sep 2013 · 6,963 accessesView PDFCite
Research ArticleOpen accessIn the abstractRelationship between Fetuin-A and Systemic Lupus Erythematosus as a Predictor Marker for AtherosclerosisOsama F. Mosa, Ibrahim H. Mohamad, Magdi M. SalamaProblem statement: Associations between serum levels of fetuin-A, C3 complement, calcium × phosphate product and calcification risk index and lipid profile in SLE patients were established. However, the mechanism of accelerated atherosclerosis accompanied with SLE remains elusive. We therefore turned to investigate the association between Fetuin-A, disease activity and accelerated atherosclerosis in patients with SLE. Approach: Serum blood samples were … …Current Research in Medicine, Vol. 3, Issue 2 · 15 Sep 2012 · 7,777 accessesView PDFCite
Research ArticleOpen accessIn the abstractAnti-β2 Glycoprotein-I Antibody in Acute Myocardial InfarctionMohammad Shojaei, Abdolreza Sotoodeh Jahromi, Hamideh Ebadat et al.Problem statement: Ischemic cardiac manifestations have been reported in a various percentage of patients with anti-phospholipid antibodies. Data concerning the relation between anti- Phospholipid (aPL) antibodies and myocardial infarction in subjects without evidence of overt autoimmune disease are conflicting. Anti-beta2 glycoprotein-I (anti-beta2-GPI) antibody is detected in various diseases like rheumatoid arthritis, systemic lupus erythematosus and anti-phospholipid antibody syndrome. The study … …American Journal of Applied Sciences, Vol. 8, Issue 8 · 18 Jul 2011 · 7,051 accessesView PDFCite
Research ArticleOpen accessIn the abstractSoluble CD14, Sialic Acid and L-Fucose in Breast Milk and their Role in Increasing the Immunity of Breast-Fed InfantsGhalib Ali Oriquat, Tahia H. Saleem, Samir T. Abdullah et al.Problem statement: Breast milk contain protective factors as soluble CD14, L-Fucose and Sialic acid which increase the innate immunity and level of intelligence, decrease the incidence of gastroenteritis, chest and other systemic diseases in newly born infants. In the present study the role of soluble CD14, L-Fucose and Sialic acid, in increasing the immunity in breastfed infants were studied to … …American Journal of Biochemistry and Biotechnology, Vol. 7, Issue 1 · 27 Apr 2011 · 10,188 accessesView PDFCite
Research ArticleOpen accessIn the abstractSepticemia: The Principal Killer of Burns PatientsB. R. Sharma, Virendar Pal Singh, Sumedha Bangar, Neha GuptaBurn injury is a major problem in many areas of the world and it has been estimated that 75% of all deaths following burns are related to infection. Burns impair the skin’s normal barrier function thus allowing microbial colonization of the burn wounds and even with the use of topical antimicrobial agents, contamination is almost unavoidable. It is therefore essential … …American Journal of Infectious Diseases, Vol. 1, Issue 3 · 30 Sep 2010 · 7,022 accessesView PDFCite
Research ArticleOpen accessIn the abstractEndothelial Dysfunction Induced by Type 2 Diabetes Mellitus and Fibrinolytic ActivityHussein F. SakrProblem statement: Type 2 diabetes mellitus is the world's largest systemic and metabolic disease. Endothelin (ET) was first described as a peptidergic endothelium-derived constricting factor. Endothelin-1 is one of the endothelial factors that is overexpressed in cases of endothelial dysfunction. The fibrinolytic system is present in plasma with the degradation of fibrin polymers in blood clots. It is a proteolytic … …American Journal of Biochemistry and Biotechnology, Vol. 6, Issue 2 · 30 Jun 2010 · 7,729 accessesView PDFCite