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21 articles for “potentially toxic”
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Research ArticleOpen accessIn the abstractNEWER DRUGS FOR VISCERAL LEISHMANIASIS: A REVIEWKrishna Pandey, Dharmendra Singh, Sanjiva Bimal et al.Visceral Leishmaniasis (VL) is one of the most neglected tropical diseases worldwide. The diagnosis and treatment of this disease is quite complex. Sodium Antimony Gluconate (SAG) which used to be a very effective treatment has now developed resistance and is potentially a cardio-toxic drug. Pentamidine has now been discarded because of adverse effect of diabetes mellitus. Amphotericin-B is an effective … …American Journal of Infectious Diseases, Vol. 10, Issue 2 · 5 May 2014 · 7,133 accessesView PDFCite
Research ArticleOpen accessIn the abstractAccumulation of Heavy Metals in Tilapia Fish (Oreochromis niloticus) from Al-Khadoud Spring, Al-Hassa, Saudi ArabiaMohammed A. Al-KahtaniProblem statement: Al-Khadoud Spring is one of the largest spring in Al-Hassa governorate (Saudi Arabia). Due to the extended domestic activities and urbanization as well as the continuous industrial and agricultural growth of the region, spring water quality is potentially changing. Approach: This study was conducted to measure toxic heavy metal concentrations in water and fish samples along the spring … …American Journal of Applied Sciences, Vol. 6, Issue 12 · 31 Dec 2009 · 11,802 accessesView PDFCite
Research ArticleOpen accessIn the abstractCamel's Milk Protects against Aluminum Chloride-Induced Toxicity in the Liver and Kidney of White Albino RatsFahaid Al-HashemProblem statement: Aluminum chloride (AlCl3) is commonly used in daily life but it can be potentially toxic. Therefore, the present study was carried out to investigate the protective effects of camel’s milk against aluminum-induced biochemical alterations and oxidative stress in the liver and kidney of white albino rats. Approach: White albino male rats (230-250 g) were divided into three groups … …American Journal of Biochemistry and Biotechnology, Vol. 5, Issue 3 · 30 Sep 2009 · 10,367 accessesView PDFCite
Research ArticleOpen accessIn the abstractEffects of D- and L-Glucose and Mannitol on Retinal Capillary Cells: Inhibition by Nanomolar AminoguanidineYongxin Yu, Wei Li, Barbara Wojciechowski et al.Hyperglycemia may contribute directly to pericyte loss and capillary leakage in early diabetic retinopathy. To elucidate relative contributions of glycation, glycoxidation, sugar autoxidation, osmotic stress and metabolic effects in glucose-mediated capillary damage, we tested the effects of D-glucose, L-glucose, mannitol and the potentially protective effects of aminoguanidine on cultured bovine retinal capillary pericytes and endothelial cells. Media (containing 5 mM … …American Journal of Pharmacology and Toxicology, Vol. 2, Issue 4 · 31 Dec 2007 · 7,749 accessesView PDFCite
Research ArticleOpen accessIn the abstractCharacteristics of Nitrogen Removal from Old Landfill Leachate by Sequencing Batch Biofilm ReactorLong Tengrui, Anas F. Al-Harbawi, Lin Ming Bo et al.Municipal landfill leachate is a high strength wastewater characterized by high concentrations of organics and ammonia and potentially containing toxic materials. The paper reports the results of a laboratory scale investigation aimed at evaluating the effectiveness of mature municipal landfill leachate treatment by a biological stage (used SBBR as a biological treatment) to study the nitrogen removal capabilities for treatment … …American Journal of Applied Sciences, Vol. 4, Issue 4 · 30 Apr 2007 · 8,039 accessesView PDFCite
Research ArticleOpen accessIn the abstractRetinoids Chemosensitize Ovarian Cancer Cell Lines to Cisplatin Independent of Nuclear Receptors and p53Suresh Guruswamy, Doris M. BenbrookTreatment of ovarian cancer with cisplatin-based chemotherapy is highly toxic and is often followed by cancer recurrence. Repeated treatments with cisplatin frequently result in the development of resistance to this drug. Drugs with low toxicity that could enhance the tumor cell killing effects of cisplatin could potentially reduce the toxicity and enhance the efficacy of cisplatin. The mechanism of cell … …American Journal of Pharmacology and Toxicology, Vol. 1, Issue 4 · 31 Dec 2006 · 6,958 accessesView PDFCite
Research ArticleOpen accessIn the abstractAnalytical Method Validation of Vilazodone with Spectrofluorimetric Detection in Rabbit PlasmaIrene Sartini, Marco Salvadori, Beata Łebkowska-Wieruszewska et al.Vilazodone (VLZ) is an antidepressant agent approved in 2011 by Food and Drug Administration (FDA) for the treatment of major depressive syndromes. Its chemical structure derives from trazodone which is used as an off-label drug for dogs and cats in order to induce sedation and reduce anxiety, behavioural and pre-and post-operative stress. VLZ could be a potentially useful compound in … …American Journal of Animal and Veterinary Sciences, Vol. 14, Issue 1 · 2 Apr 2019 · 7,740 accessesView PDFCite
Research ArticleOpen accessIn the abstractPREPARATION OF ACTIVATED CARBON FROM PALM OIL SHELL BY CHEMICAL ACTIVATION WITH Na2CO3 AND ZnCl2 AS IMPRENATED AGENTS FOR H2S ADSORPTIONKanokorn HussaroHydrogen Sulfide (H2S, rotten-egg) is one of the major environmental pollutants having its sources in natural and anthropogenic activities. It’s had smell gas produced by anaerobic digestion in acid condition from organic and inorganic compounds containing sulphur, presents dual problems of its toxicity and foul ordour. One of methods of its removal is adsorption. Activated carbon is a widely used … …American Journal of Environmental Sciences, Vol. 10, Issue 4 · 17 Jun 2014 · 8,480 accessesView PDFCite
Research ArticleOpen accessIn the abstractThe Frequency of Polymorphisms affecting Lead and Mercury Toxicity among Children with AutismShannon Rose, Stepan Melnyk, Alena Savenka et al.Individual risk of developmental neurotoxicity with exposure to environmentally relevant levels of lead and mercury is likely to be determined by genetic susceptibility factors as well as additive interactions with other environmental pollutants, cumulative dose, and the developmental stage of exposure. The apparent increase in autism diagnosis over the last 15 years has enhanced interest in the possibility that an … …American Journal of Biochemistry and Biotechnology, Vol. 4, Issue 2 · 30 Jun 2008 · 7,521 accessesView PDFCite
Research ArticleOpen accessIn the abstractEarly Cellular Responses of Purine Nucleoside-mediated Protection of Hypoxia-induced Injuries of Neuronal PC12 CellsBettina Tomaselli, Valerie Podhraski, Günther Böck, Gabriele Baier-BitterlichHypoxia in brain may lead to cell death by apoptosis and necrosis. In parallel adenosine, a powerful endogenous neuroprotectant is formed. We wanted to investigate the effect of adenosine and its purine nucleoside relatives, inosine and guanosine on early cellular responses to hypoxia. O2-sensitive neuronal PC12-cells were subjected to chemical hypoxia induced with rotenone, an inhibitor of mitochondrial complex I. … …American Journal of Biochemistry and Biotechnology, Vol. 1, Issue 3 · 30 Sep 2005 · 6,853 accessesView PDFCite