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Research ArticleOpen accessIn the abstractBridging Innovation and Access: Randomized, Single-Dose, Open-Label, Parallel-Group Bioequivalence Study of Generic and Innovator Injection Semaglutide in IndiaMayur Madhav Mayabhate, Nitin Kapure, Akhilesh Sharma, Radhakrishna VaddemSemaglutide, a long-acting Glucagon-Like Peptide-1 (GLP-1) receptor agonist, is effective in improving glycemic control, reducing body weight, and lowering cardiovascular risk in Type 2 Diabetes Mellitus (T2DM). Limited accessibility of the innovator formulation underscores the need for bioequivalent generic alternatives. To assess the pharmacokinetic bioequivalence of a synthetic Semaglutide Injection (2 mg/1.5 mL) developed by Alkem Laboratories Ltd., India, compared … …American Journal of Pharmacology and Toxicology, Vol. 20, Issue 1 · 20 Apr 2026 · 2,626 accessesView PDFCite
Research ArticleOpen accessIn the abstractMMP-9 is a Potential Prognostic Marker of Left Ventricular Remodeling in Patients with Coronary Artery DiseaseMikhail Aleksandrovich Popov, Anastasia Vladimirovna Poznyak, Dmitry Valerievich Shumakov et al.Matrix Metalloproteinase-9 (MMP-9) emerges as a promising prognostic marker for assessing left ventricular remodeling in patients with coronary artery disease, particularly in the context of Ischemic Heart Disease (IHD) complicated by left ventricular aneurysm. In this study, we conducted two parallel investigations to explore the prognostic significance of MMP-9 in patients with multivessel coronary artery disease undergoing left ventricular reconstruction … …OnLine Journal of Biological Sciences, Vol. 24, Issue 4 · 11 Jul 2024 · 4,310 accessesView PDFCite
Review ArticleOpen accessIn the abstractThe Impact of Di-2-Ethylhexyl Phthalate (DEHP) in Focus on the Reproductive System and Toxicity in Rat or Mammalian ModelVenkataramanaiah Poli, Srinivasulu Reddy MotireddyAbsalan, F., Saremy, S., Mansouri, E., Moghadam, M. T., Moghadam, A. R. E., & Razie, G. (2016). Effects of Mono-(2-Ethylhexyl) Phthalate and Di-(2-Ethylhexyl) Phthalate Administrations on Oocyte Meiotic Maturation, Apoptosis and Gene Quantification in Mouse Model. Cell Journal, 18(4), 503–513. https://doi.org/10.22074/cellj.2016.4717 Acevedo‐Rodriguez, A., Kauffman, A. S., Cherrington, B. D., Borges, C. S., Roepke, T. A., & Laconi, M. (2018). Emerging … …American Journal of Pharmacology and Toxicology, Vol. 19, Issue 1 · 6 Jun 2024 · 12,990 accessesView PDFCite
Research ArticleOpen accessIn the abstractDietary Inclusion of Sunflower Seed Alters Blood Plasma and Endometrium Lipid Profile in Beef CowsMariângela Bueno Cordeiro Maldonado, Ricardo de Oliveira Rodrigues, Dante Pazzanese Duarte Lanna et al.Polyunsaturated Fatty Acids (PUFA)-enriched diets are recognized as a significant approach for improving the reproductive efficiency of cattle. The aim of this study was to evaluate the effects of sunflower seed, a PUFA-rich feed source, supplementation on plasma and endometrium lipid profiles in beef cattle. It was hypothesized that feeding of sunflower seed has an additional effect on PUFA that … …American Journal of Animal and Veterinary Sciences, Vol. 18, Issue 2 · 25 Jul 2023 · 5,547 accessesView PDFCite
Research ArticleOpen accessIn the abstractStudy the Efficacy of Different Concentrations of Coconut Water on Boar Semen Following Equilibration at 18°C for Different HoursMduduzi M. Tshabalala, Masindi L. Mphaphathi, Thivhilaheli R. Netshirovha et al.A rich natural resourcesuch as Coconut Water (CCW) features high concentrations of antioxidants,nutrients, amino acids, sugars, and electrolytes. These herbal extractinfusions are used in semen extenders to preserve animal sperm. In addition,CCW is important for in vitro productionof embryos. The purpose of this study was to investigate the use of coconutwater as an alternative bulking agent for boar semen after … …American Journal of Animal and Veterinary Sciences, Vol. 17, Issue 4 · 23 Nov 2022 · 7,040 accessesView PDFCite
Research ArticleOpen accessIn the abstractLevels of Trace and Other Selected Metals in Mixed Teff Grain SamplesAbraha Gebregewergis WeldehawariaTeff (Eragrostis tef (Zuccagni)) is a hugely important crop to Ethiopia both in terms of production and consumption. In terms of production, teff is the dominant cereal by area coverage and second only to maize in production and consumption. The principal use of teff grain for human food in Ethiopia is in the form of Injera, a soft porous thin … …American Journal of Agricultural and Biological Sciences, Vol. 17, Issue 1 · 19 Feb 2022 · 7,124 accessesView PDFCite
Research ArticleOpen accessIn the abstractTrace Elements in Fertilizers Used in PeruVíctor Gómez, Mauricio Molina-Roco, Elder Chichipe, Eli Morales RojasFertilizers provide essential nutrients for crops, however, they may also inadvertently provide trace elements that in certain concentrations represent a risk to the soil and the food chain. The objective of this research was to determine the concentrations of Cd, Pb, Cu, and Zn in the most common fertilizers used in Peruvian agriculture. Twenty-one products including inorganic, organic mineral, and … …OnLine Journal of Biological Sciences, Vol. 23, Issue 2 · 10 Apr 2023 · 6,440 accessesView PDFCite
Research ArticleOpen accessIn the abstractStudy the Effect of Extracted Low-Density Lipoprotein from Egg Yolk on the Cryopreservation of Nguni Bull SemenMduduzi M. Tshabalala, Masindi Lottus Mphaphathi, Khathutshedzo A. Nephawe et al.The mechanism on how Egg Yolk (EY) helps sperm to survive the low temperature outside the animal body during cryopreservation and thawing process is not yet known. It is usually believed that the Low-Density Lipoprotein (LDL) is the major component that provides protection. The present study was undertaken to assess the cryo-protective effect of different concentrations (6, 8, 10 and … …American Journal of Animal and Veterinary Sciences, Vol. 16, Issue 3 · 13 Sep 2021 · 6,915 accessesView PDFCite
Research ArticleOpen accessIn the abstractCorpus Luteum Morphology and Function After Timed Artificial Insemination (TAI) in Nelore Heifers Supplemented with Sunflower Seed in their DietsGabriel Molinari de Mattos, Beatriz de Moraes Ropelli, Claudia Maria Bertan Membrive et al.The dietary Polyunsaturated Fatty Acids (PUFA) supplementation, before the Timed Artificial Insemination (TAI) protocol, may contribute to a reduction in embryonic mortality. In this context, we hypothesized that dietary supplementation with sunflower seed, before the TAI protocol, will promote an increase in the ovulatory Follicle Diameter (FD), with a consequent increase in the Corpus Luteum Diameter (CLD) and the plasma … …American Journal of Animal and Veterinary Sciences, Vol. 16, Issue 3 · 12 Jul 2021 · 7,053 accessesView PDFCite
Research ArticleOpen accessIn the abstractStudies on Pharmacokinetics and Liver Microsome Metabolism of Nuciferine in Different Species of AnimalsDong Xiao-Chen, Liu Ming-Qi, Liu Jun et al.This study aimed to compare the characteristics of pharmacokinetics and liver microsome metabolism among different species of animals including rabbit, rat and mouse and healthy New Zealand white rabbits, SPF Sprague Dawley (SD) rats and ICR mice were given intraperitoneal injection of nuciferine at a dose of 50 mg per kg body weight. Blood samples were collected via caudal vein … …American Journal of Biochemistry and Biotechnology, Vol. 17, Issue 3 · 12 Aug 2021 · 6,468 accessesView PDFCite