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45 articles for “over-expression”
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EditorialOpen accessIn the abstractIs Rerum® the New Coley's Vaccine?Marco RuggieroColey's Vaccine and Cancer Immunotherapy Dr. William B. Coley is credited for having been the first to translate the observation of an association between bacterial infections, high fever and cancer remission into a successful cancer treatment. However, it is worth noting that such an association dates back to at least one century before Coley's times; as Wiemann and Starnes from … …American Journal of Immunology, Vol. 13, Issue 2 · 31 May 2017 · 12,281 accessesView PDFCite
Research ArticleOpen accessIn the abstractIdentification and Characterization of Diacylglycerol Acyltransferase in Oleaginous Yeast Rhodosporidium toruloidesZhen Wang, Huaiyuan Zhang, Lina Zhao, Yuanda SongDiacylglycerol acyltransferase (DGAT), which catalyzes TAG formation from DAG and acyl-CoA, has been considered to play a vital role in TAG accumulation in oleaginous microorganisms. The genome of oleaginous yeast Rhodosporidium toruloides contains two putative DGAT genes, RtDGATa and RtDGATb, which shared little conserved amino acid coding sequence with each other. Phylogeny tree analysis showed that RtDGATa belonged to DGAT1 … …American Journal of Biochemistry and Biotechnology, Vol. 12, Issue 4 · 17 Oct 2016 · 7,387 accessesView PDFCite
Research ArticleOpen accessIn the abstractGene Expression Profiling of Toll-Like Receptor 4 and 5 in Peripheral Blood Mononuclear Cells of Patients with Systemic SclerosisSimin Almasi, Saeed Aslani, Hadi Poormoghim et al.The Toll-Like Receptor (TLR) family is appeared to be expressed in many cell types in the immune system and plays a role in the pathogenesis of various autoimmune diseases. The expression profile and role of TLRs in Systemic Sclerosis (SSc) have been partly explained. It is aimed through this investigation to evaluate the expression pattern of TLR 4 and 5 … …American Journal of Immunology, Vol. 12, Issue 1 · 17 Mar 2016 · 7,049 accessesView PDFCite
EditorialOpen accessIn the abstractRECENT TRENDS AND CHALLENGES OF ENERGY EFFICIENT AND SUSTAINABLE BUILDINGSChiara BedonAccording to several studies (e.g., the Intergovernmental Panel on Climate Change (IPCC, 2014), the US Energy Information Administration (US EIA, 2014), warming of the climate system is unequivocal and mainly derives from greenhouse gas emissions due to human activities. Global Carbon Dioxide (CO2) emissions from fossil fuels, for example, are estimated to be 29% higher in 2035 than they were … …American Journal of Engineering and Applied Sciences, Vol. 7, Issue 3 · 11 Sep 2014 · 8,497 accessesView PDFCite
Research ArticleOpen accessIn the abstractGENE IMPRINTING: ENGRAVING THE PATHOGENESIS OF HERIDETARY DISEASESSandeep Satapathy, Roshan Kumar Singh, Harikrishnan RajendranGene imprinting has conduited the scope of our understanding of phenotypic expression and its corelation with constituent genotype. It is an epigenetic process that involves DNA methylation and histone modulation to attain monoallelic gene expression without altering the genetic sequences. A distinctive model of non-mendelian genetics, imprinting extends the control over expression of traits and selection of the allele that … …American Journal of Immunology, Vol. 10, Issue 1 · 12 Feb 2014 · 7,682 accessesView PDFCite
Research ArticleOpen accessIn the abstractCo-Inhibitory Molecule Programmed Death-1 and its Ligands: A New Alternative Therapy for Human Immunodeficiency Virus Infection?A. Leon-Flores, P. Del Rio, G. Reyes-TeranChronic viral infections are characterized by the up-regulation of a set of immunomodulatory receptors. The over-expression of co-inhibitory molecules on T cells leads to a dysfunctional T cell response with an "exhausted" phenotype. Programmed Death-1 (PD-1) is a molecule that exerts an inhibitory signal on the T cell receptor when it binds to the PD-L1 or PD-L2 ligands present on … …American Journal of Infectious Diseases, Vol. 8, Issue 4 · 28 Dec 2012 · 6,962 accessesView PDFCite
Research ArticleOpen accessIn the abstractThe Transboundary Movement of Hazardous Waste: A Contribution to Improve the Present Technical-Judicial ModelGiancarlo Carosso, Cesare Luceri, Pierpaolo OresteThe expression &#34the transboundary movement of hazardous waste&#34 refers, from the technical point of view, to a series of phases that begin with the creation of a hazardous waste and includes its identification according to international, regional and national standards, its delivery to specialized companies and its movement from the exporting country to the importing country; these phases end with … …American Journal of Environmental Sciences, Vol. 8, Issue 4 · 13 Jul 2012 · 7,148 accessesView PDFCite
Research ArticleOpen accessIn the abstractRole of Progranulin Gene Expression as a Molecular Biomarker for Bladder CancerSalwa M. Abo El-khair, Mie A. Mohamed, Tamer E. AlkhiaryBladder cancer is the second most common cancer of the urinary system. Early diagnosis of this tumor and estimation of risk of future progression has a significant impact on prognosis. Although there are several molecular markers for the diagnosis and prognosis for this tumor, their accuracy is not ideal. Progranulin is a growth factor that may play a critical role … …American Journal of Biochemistry and Biotechnology, Vol. 8, Issue 2 · 22 Jun 2012 · 7,699 accessesView PDFCite
Research ArticleOpen accessIn the abstractA Cyanobacterium Synechocystis sp. PCC 6803 Glutaredoxin Gene (slr1562) Protects Escherichia coli against Abiotic StressesAhmed Gaber, Salah El-Din El-AssalProblem statement: Glutaredoxins (GRXs) are ubiquitous small heat stable glutathione-dependent oxidoreductase enzymes that play a crucial role in plant development and response to oxidative stress. Approach: Cyanobacterium Synechocystis strain PCC 6803 contains two genes (slr1562 and ssr2061) encoding glutaredoxins. In the present investigation the slr1562 gene (grxC) was isolated and characterized. Results: The results revealed that the amino acid sequence … …American Journal of Agricultural and Biological Sciences, Vol. 7, Issue 1 · 5 Mar 2012 · 7,582 accessesView PDFCite
Research ArticleOpen accessIn the abstractExpression of the CD44 Protein in the Heart Valves Affected with Rheumatic Heart DiseaseR. Vijayalakshmi, S. Nayar, K.M. CherianProblem statement: The primary aim was to study the expression of CD44 protein in the heart valves removed surgically for either stenosis or regurgitation and to study the morphology of valves using histochemical staining. Approach: We studied 107 valves which were collected from the International Centre for Cardio Thoracic and Vascular Diseases. Results: Aortic and mitral valves were obtained from … …American Journal of Infectious Diseases, Vol. 6, Issue 4 · 31 Dec 2010 · 7,406 accessesView PDFCite