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Research ArticleOpen accessIn the abstractEvaluation of the Renoprotective Effects of Valsartan in Methotrexate-Induced Acute Kidney Injury in RatsDina KutbiMethotrexate (MTX) is a widely used chemotherapeutic agent known for its nephrotoxic effects, which can lead to acute kidney injury in hospitalized patients. However, the mechanism by which MTX induces nephrotoxicity is not entirely clear, but it is believed to involve oxidative stress and direct toxic effects on renal tubules. Valsartan, an angiotensin II receptor blocker, has been shown to … …OnLine Journal of Biological Sciences, Vol. 24, Issue 3 · 4 May 2024 · 4,574 accessesView PDFCite
Research ArticleOpen accessIn the abstractDistribution of Alleles and Genotypes of ACE2 Gene Polymorphisms (rs2285666 and rs35803318) and Association with COVID-19 Among Populations in KazakhstanAnar Bisseneva, Konstantin Li, Gayane Pogossyan, Valeriya ProtasThere is still no definitive confirmation regarding the association between ACE2 gene polymorphisms and COVID-19. This study was conducted to analyze the distribution of alleles and genotypes of the ACE2 gene rs2285666 and rs35803318 two polymorphisms and their possible association with COVID-19 among two ethnic groups, namely, the Kazakhs and Eastern Slavs, residing within the same geographic area in the … …OnLine Journal of Biological Sciences, Vol. 24, Issue 1 · 31 Oct 2023 · 4,943 accessesView PDFCite
Short CommunicationsOpen accessIn the abstractCytotoxicity and Apoptosis-Induction Potential of Fraction F3 from Fruits of Bersama engleriana (Melanthaceae) against Human Cervical Cancer CellsMichèle Stella Majoumouo et al.Cervical cancer is one of the most life-threatening malignancies worldwide, despite intensive research for more efficacious chemotherapeutic agents. Recent efforts geared towards eradicating the scourge of cancer have embodied a major surge of interest in natural products as promising lead molecules in pharmaceutical development and therapeutic translation. Consequently, this study aimed to assess the cytotoxicity of a previously identified plant … …American Journal of Biochemistry and Biotechnology, Vol. 18, Issue 4 · 5 Dec 2022 · 5,294 accessesView PDFCite
Literature ReviewOpen accessIn the abstractOptimization of Extraction of Cannabinoids and Flavonoids Substances from Influence Cannabis sp. and their Biological Activities before and after DecarboxylationOlga Kronusová, Michala Piklová, Kristýna Šírová et al.Inflorescence of eight different varieties of Cannabis sp. (3 hemp varieties and 5 medical cannabis varieties) were subjected to extraction with n-hexane or ethanol as representatives of non-polar and polar solvents. Crude extracts were either used directly or after decarboxylation of cannabis acids for measurement of selected biological activities-cytotoxicity against carcinogenic line B16 (musculus skin melanoma cells), cytotoxicity against Human … …American Journal of Applied Sciences, Vol. 19, Issue 1 · 26 May 2022 · 6,741 accessesView PDFCite
Research ArticleOpen accessIn the abstractEffect of Cinnamomum cassia Stem-Bark Extracts on the Synthesis and Secretion of Insulin in RIN-m5F CellsAnanias Hodi Kgopa, Sebolaishi Doris Makhubela, Motetelo Alfred Mogale, Leshweni Jerry ShaiCinnamomum cassia (C. cassia) crude stem-bark extracts possess some hypoglycemic properties through inhibiting the uptake of glucose by the intestines and/or enhancing insulin sensitivity. To further investigate the mechanism through which the hypoglycemic effect is exerted, this research explored the influence of the extracts of the crude stem-bark of C. cassia, with various polarities, on particular aspects of glucose consumption … …OnLine Journal of Biological Sciences, Vol. 22, Issue 2 · 5 Apr 2022 · 5,788 accessesView PDFCite
Research ArticleOpen accessIn the abstractAnthelmintic Treatment in Growing Cattle: A Preliminary Study on the Effect of Ricobendazole on the Fecal MicrobiomePablo Rovira, Pablo LorenzoThere is limited information on the impact that anthelmintic treatments exert on the fecal microbiome of growing cattle. This study characterizes the composition and metabolic function of the cattle gut microbiome associated with different levels of parasite Fecal Egg Counts (FEC) and characterizes the fecal microbiome before and after ricobendazole-treatment. The hypothesis was that FEC levels and ricobendazole treatment (8 … …American Journal of Animal and Veterinary Sciences, Vol. 17, Issue 1 · 31 Mar 2022 · 6,344 accessesView PDFCite
Research ArticleOpen accessIn the abstractRelease of Endogenous Chondroitin Sulfate and Heparin as Consequence of Dysregulated Proteolysis in COVID-19Marco RuggieroInfection by severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2), the pathogen responsible for COVID-19, is associated with immune-mediated responses that lead to dysregulated activation of proteolytic enzymes; these contribute to damage to the endothelium, thrombosis, hypercoagulability and other hematologic complications that include thrombotic thrombocytopenia, a complication of severe COVID-19 as well as a potentially fatal adverse effect of COVID-19 vaccination. … …American Journal of Immunology, Vol. 17, Issue 1 · 29 Dec 2021 · 7,691 accessesView PDFCite
Research ArticleOpen accessIn the abstractMomordica balsamina Fruit Extracts Enhances Selected Aspects of the Insulin Synthesis/Secretion PathwayAnanias Hodi Kgopa, Leshweni Jerry Shai, Motetelo Alfred MogalePrevious studies have suggested that crude plant extracts of the anti-diabetic medicinal plant, Momordica balsamina (MB) may exert their anti-diabetic effect through either enhancement of insulin sensitivity or inhibition of intestinal glucose absorption. However, the effects of these MB extracts on insulin synthesis and secretion are not well documented in the literature. Therefore, a main purpose of the current research … …American Journal of Biochemistry and Biotechnology, Vol. 16, Issue 4 · 17 Dec 2020 · 7,003 accessesView PDFCite
Literature ReviewOpen accessIn the abstractFundamental Questions about γδT CellsMoulay Yassine Belghali, Saadia Ba-M’hamed, Mouna Khouchani, Brahim AdmouγδT cells is a minor subgroup of T lymphocytes expressing γδ-T Cell Receptor (TCR), with many subsets, dominated by Vδ2 and Vδ1. γδT cells recognize antigens independently of the context of MHC class I, MHC class II, or CD1 presenting molecules. However, this recognition requires the expression of the transmembrane Butyrophilin proteins by the presenting cells. Their activation is controlled … …OnLine Journal of Biological Sciences, Vol. 20, Issue 4 · 15 Dec 2020 · 6,384 accessesView PDFCite
Review ArticleOpen accessIn the abstractPlant Growth Promoting Rhizobacteria (PGPR): A Novel Agent for Sustainable Food ProductionOdoh Chuks Kenneth, Eze Chibuzor Nwadibe, Akpi Uchenna Kalu, Unah Victor UnahPlant Growth Promoting Rhizobacteria (PGPR) involves the use of large array of soil bacteria to improve yield, plant growth and sustainable food production. As free living and symbiotic rhizobacteria, PGPR exert its role by colonizing extracellular and/or intracellular rhizoenvironment in the quest for carbon source. In the past decades, focus has been on developing a biosafety agro base approach void … …American Journal of Agricultural and Biological Sciences, Vol. 14, Issue 1 · 19 Apr 2018 · 14,191 accessesView PDFCite