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235 results for “drug use”
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Literature ReviewOpen accessIn the keywordsMycobacterium Abscessus Native Tricuspid Valve Endocarditis. Is a Six-Week Course of Combination Antibiotic Therapy Enough?Rabindra Ghimire, Dora Lebron, William Matthew Wooten et al.A 24-year-old Caucasian woman with a history of intravenous drug abuse and multiple hospital admissions for substance abuse related medical problems presented with pneumonia and was discharged home on oral antibiotics. Three days later, her blood culture grew acid fast bacilli, which was subsequently identified as M. abscessus subspecies abscessus. Transthoracic and transesophageal echocardiogram (TTE and TEE respectively) was suggestive … …American Journal of Infectious Diseases, Vol. 16, Issue 1 · 20 Feb 2020 · 7,285 accessesView PDFCite
Research ArticleOpen accessIn the abstractAssessing the Gender Dimensions of Drug Abuse Among Women and Girls in Maiduguri: Challenges and ImplicationsFredrick WilsonThis study examines the gender-specific dimensions of drug abuse among women and girls in Maiduguri, North East Nigeria, a region affected by insurgency, poverty, and restrictive socio-cultural norms. While national data indicate rising female substance use, interventions and research have largely overlooked women’s unique challenges. Drawing on in-depth interviews and focus group discussions, the study explores structural, emotional, and socio-cultural … …Journal of Social Sciences, Vol. 22, Issue 1 · 7 Sep 2026 · 816 accessesView PDFCite
Review ArticleOpen accessIn the abstractThe Impact of Di-2-Ethylhexyl Phthalate (DEHP) in Focus on the Reproductive System and Toxicity in Rat or Mammalian ModelVenkataramanaiah Poli, Srinivasulu Reddy MotireddyAbsalan, F., Saremy, S., Mansouri, E., Moghadam, M. T., Moghadam, A. R. E., & Razie, G. (2016). Effects of Mono-(2-Ethylhexyl) Phthalate and Di-(2-Ethylhexyl) Phthalate Administrations on Oocyte Meiotic Maturation, Apoptosis and Gene Quantification in Mouse Model. Cell Journal, 18(4), 503–513. https://doi.org/10.22074/cellj.2016.4717 Acevedo‐Rodriguez, A., Kauffman, A. S., Cherrington, B. D., Borges, C. S., Roepke, T. A., & Laconi, M. (2018). Emerging … …American Journal of Pharmacology and Toxicology, Vol. 19, Issue 1 · 6 Jun 2024 · 13,008 accessesView PDFCite
Research ArticleOpen accessIn the abstractOptic Neuropathy: Characteristic Pathology for Identifying Drugs with Potential to Cause Mitochondrial ToxicityConnor Dyer, Katlyn Droke, Ugne Zekonyte, Mariana RoscaDeleterious effects on mitochondria are known to be frequently caused by prescription drugs, however, there is no standard and specific testing by pharmaceutical companies on these effects on mitochondria during drug development. The objective of this study is to determine if cases of optic neuropathy are related to drug-induced mitochondrial toxicity in a way that could be used to predict … …American Journal of Pharmacology and Toxicology, Vol. 18, Issue 1 · 19 Jan 2024 · 8,567 accessesView PDFCite
Research ArticleOpen accessIn the abstractUnveiling the Potential of Dombeya buettneri K.Schum As a Drug Agent: Molecular Docking of Compounds With Enzymes Linked to Diabetes and Neurodegenerative DiseaseEsther Emem Nwanna, Samuel Chima Ugbaja et al.This study investigated the mechanisms of Dombeya buettneri (snowball leafy) extracts on diabetes, hypertension, and neurodegenerative diseases. It compared extracts obtained using steep water (a by-product of corn wet milling) and aqueous water. The extracts were analyzed for total phenol, total flavonoid content, antioxidant activities such as FRAP, ABTS, NO, DPPH, iron-induced lipid peroxidation assay, degradation of deoxyribose (Fenton’s reaction), … …OnLine Journal of Biological Sciences, Vol. 25, Issue 4 · 1 Feb 2026 · 2,031 accessesView PDFCite
Review ArticleOpen accessIn the abstractDrug Repositioning in Response to COVID-19 and other Challenging DiseasesHyellavala Joseph Fomnya, Saidu Ibrahim Ngulde, Sarah Malgwi Gana et al.Coronavirus disease is a highly contagious infection that is majorly associated with upper respiratory tract illnesses. The World Health Organization (WHO) label the novel coronavirus disease COVID-19 after an epidemic of the disease in Wuhan, Hubei province (China). Over 90 clinical trials, including drug repositioning, have been initiated to get COVID-19 treatment/management. Antibiotic resistance, drug tolerance, mutation, and adverse drug … …American Journal of Pharmacology and Toxicology, Vol. 17, Issue 1 · 28 Nov 2022 · 9,508 accessesView PDFCite
Review ArticleOpen accessIn the abstractDrug Interactions Pharmacology: A Narrative ReviewLívia Maria Barbosa Neves, Louryanne de Castro Silva, Mônica Thalia Brito de Melo et al.Thesimultaneous prescription of multiple drugs used in therapeutic schemes canresult in drug interactions, with desirable or undesirable effects. Thus, theobjective of this study was to describe the mechanisms involved in clinicallyrelevant drug interactions. This is a narrative review in which studiespublished in PUBMED and the VHL were searched in the following databases:MedLine, Lilacs, and Scielo. The search was performed in … …American Journal of Pharmacology and Toxicology, Vol. 17, Issue 1 · 25 Oct 2022 · 9,161 accessesView PDFCite
Research ArticleOpen accessIn the abstractIdentification of Microbe-Drug Association based on Weighted Profile and Collaborative Matrix FactorizationZhu Ling-Zhi, Guixiang Li, Chunhua Li, Jun WangPrevious studies have shown that diseases are associated with microbe. To explore a more effective treatment for these diseases, unknown microbe-drug associations must be identified. However, existing models to identify microbe-drug association are limited. In our article, a predictive model (WPCMF) is presented for identifying microbe-drug associations based on weighted profile and collaborative matrix factorization. In WPCMF, the Gaussian Interaction … …American Journal of Biochemistry and Biotechnology, Vol. 17, Issue 4 · 23 Jan 2022 · 5,741 accessesView PDFCite
Research ArticleOpen accessIn the abstractImplementation of Antimicrobial Stewardship Program During COVID-19 Era: Cost Effectiveness and Mortality RatesSafaa Alkhiami, Anass Qasem, Hussein Mohamed Hussein, Ali AbdallaThe growing spread of antimicrobial resistance is a major problem on a global level that has provoked several health and government organizations to call for action to counteract the problem. The frequent misuse of antibiotics is prevalent within hospital settings, especially during the COVID-19 era. The introduction of antibiotic stewardship initiatives has demonstrated the capability to decrease both unwarranted antibiotic … …American Journal of Infectious Diseases, Vol. 19, Issue 4 · 30 Jan 2024 · 6,292 accessesView PDFCite
Research ArticleOpen accessIn the abstractAssociation of Remdesivir with Poor Clinical Outcomes in COVID-19-A Single Center ExperienceRajat Ranka, Arjun, Prasan Kumar Panda et al.The need for an antiviral against COVID-19 prompted clinical trials worldwide and based on initial promising trends, remdesivir was widely used, including in India (compassionate use). Subsequent trials have been conflicting in their results and the utility of the drug has been widely debated. This is a record-based retrospective cohort study in a 1000-bedded government teaching hospital in North India. … …American Journal of Pharmacology and Toxicology, Vol. 17, Issue 1 · 3 Jun 2022 · 7,212 accessesView PDFCite