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47 articles for “drug interaction”
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Research ArticleOpen accessIn the abstractIn silico and in vitro Structural Analysis on the Interaction of Calmodulin and Calmodulin-Binding Motif of FKBP35 from Plasmodium knowlesiSazlinawatie Aladin, Cahyo Budiman et al.FK506-binding protein 35 (FKBP35) is a peptidyl-prolyl cis-trans isomerase found in Plasmodium knowlesi, a zoonotic malaria parasite responsible for concerning cases of malaria infection in East Malaysia. This protein contains a segment known as the calmodulin-binding motif (Pk-CBM), which is predicted to facilitate interaction with calmodulin from P. knowlesi (Pk-CaM). Although this interaction is considered promising for future antimalarial drug … …OnLine Journal of Biological Sciences, Vol. 25, Issue 2 · 10 Mar 2025 · 4,846 accessesView PDFCite
Research ArticleOpen accessIn the abstractUnveiling the Potential of Dombeya buettneri K.Schum As a Drug Agent: Molecular Docking of Compounds With Enzymes Linked to Diabetes and Neurodegenerative DiseaseEsther Emem Nwanna, Samuel Chima Ugbaja et al.This study investigated the mechanisms of Dombeya buettneri (snowball leafy) extracts on diabetes, hypertension, and neurodegenerative diseases. It compared extracts obtained using steep water (a by-product of corn wet milling) and aqueous water. The extracts were analyzed for total phenol, total flavonoid content, antioxidant activities such as FRAP, ABTS, NO, DPPH, iron-induced lipid peroxidation assay, degradation of deoxyribose (Fenton’s reaction), … …OnLine Journal of Biological Sciences, Vol. 25, Issue 4 · 1 Feb 2026 · 2,025 accessesView PDFCite
Research ArticleOpen accessIn the abstractImpact of Integrated Nursing and Digital Droplet PCR on Bullous Dermatoid Conditions: A Randomized Controlled TrialConghui ChenBullous skin disease is an autoimmune disease characterized by the formation of blisters on the skin or mucous membrane, which seriously impairs the quality of life and overall health. Similar to the research on biomolecules (mechanics of protein interaction), cells (including cell membrane elasticity, cell adhesion, cytoskeletal dynamics, response to mechanical stimulation, cell deformation and cell endoforce transfer) and tissue … …American Journal of Biochemistry and Biotechnology, Vol. 22, Issue 2 · 2 Jul 2026 · 985 accessesView PDFCite
Research ArticleOpen accessIn the abstractComputational Validation of Selected Compounds from the GC-MS Profile of Abies numidica Essential Oil and their Antibacterial EffectsAbdelouahab Dehimat, Boudjellal Fayssal, Salem Dounya et al.This work examined the chemical composition of the Algerian endemic tree Abies numidica (Pinaceae) and investigated the antibacterial potential of three major constituents of its essential oil-Santene, Linalyl acetate, and 2,6-Octadiene-2,6-dimethyl-as reported in previously published GC-MS data. Computational antibacterial screening was carried out by docking the selected compounds onto the bacterial proteins 5Z9N (Staphylococcus aureus) and 3AQC (Micrococcus luteus). Molecular … …Current Research in Bioinformatics, Vol. 10, Issue 1 · 24 Jan 2026 · 2,939 accessesView PDFCite
Review ArticleOpen accessIn the abstractThe Impact of Di-2-Ethylhexyl Phthalate (DEHP) in Focus on the Reproductive System and Toxicity in Rat or Mammalian ModelVenkataramanaiah Poli, Srinivasulu Reddy MotireddyAbsalan, F., Saremy, S., Mansouri, E., Moghadam, M. T., Moghadam, A. R. E., & Razie, G. (2016). Effects of Mono-(2-Ethylhexyl) Phthalate and Di-(2-Ethylhexyl) Phthalate Administrations on Oocyte Meiotic Maturation, Apoptosis and Gene Quantification in Mouse Model. Cell Journal, 18(4), 503–513. https://doi.org/10.22074/cellj.2016.4717 Acevedo‐Rodriguez, A., Kauffman, A. S., Cherrington, B. D., Borges, C. S., Roepke, T. A., & Laconi, M. (2018). Emerging … …American Journal of Pharmacology and Toxicology, Vol. 19, Issue 1 · 6 Jun 2024 · 12,990 accessesView PDFCite
Research ArticleOpen accessIn the abstractMechanism Analysis of Artemisinin and Artesunate as Lung Cancer Therapy Agents Through in Silico MethodDidik Harmoko, Vivitri Dewi Prasasty, Adi YulandiSeveral in vitro studies have focused on the ability of artemisinin and its derivatives to suppress lung cancer cells, but there are still many biological processes and mechanisms, such as the interactions between the active compounds (ligands) and receptors that are not well understood and require further research. Drug targeting for lung cancer will be more precise and the inhibition … …OnLine Journal of Biological Sciences, Vol. 24, Issue 3 · 15 Feb 2024 · 6,144 accessesView PDFCite
Research ArticleOpen accessIn the abstractKRLSMDA: Identifying Human miRNA–Disease Association Based on Similarity and Kronecker Regularized Least Squares MethodLingzhi Zhu, Weimin Gao, Guixiang Li et al.A growing number of studies have suggested that miRNAs (microRNAs) have associations with human diseases, the design and discovery of drug. But so far, we do not yet fully understand the molecular mechanism of miRNAs in the development of human diseases. Predicting miRNA-disease associations is helpful for understanding the molecular mechanism of miRNAs in the development of human diseases. However, … …American Journal of Biochemistry and Biotechnology, Vol. 17, Issue 1 · 15 Mar 2021 · 6,403 accessesView PDFCite
Research ArticleOpen accessIn the abstractThe Construction of Two and Three Dimensional Molecular Models for the miR-31 and Its Silencer as the Triple Negative Breast Cancer BiomarkersArli Aditya ParikesitThe Triple Negative Breast Cancer (TNBC) is considered as the most difficult Breast Cancer type to be medicated. So far, the acceptable medication and diagnostics measure are based upon the proteomics-world view, especially with utilizing the natural products and their derivatives as drug candidates. However, as the transcriptomics-studies are getting more advanced, the research on non-coding (nc)RNA is being considered … …OnLine Journal of Biological Sciences, Vol. 18, Issue 4 · 18 Oct 2018 · 7,772 accessesView PDFCite
Research ArticleOpen accessIn the abstractEssential Proteins Discovery Methods based on the Protein-Protein Interaction NetworksLingZhi Zhu, Junling Zhang, Lingya He et al.Essential proteins are closely related to biological survival or reproduction and have important application value in respect of the location of disease genes, disease diagnosis and treatment, drug design. In order to discovery essential proteins, the researchers have proposed experimental approaches, but these methods require laborious and time consuming. With the development of high-throughput sequencing techniques, plenty of computational methods … …American Journal of Biochemistry and Biotechnology, Vol. 13, Issue 4 · 1 Jan 2018 · 8,891 accessesView PDFCite
Research ArticleOpen accessIn the abstractDesigning of Disulfide Cyclic Peptide for Inhibiting Polymerase A and B1 (PAC-PB1N) in H1N1 Virus using Molecular Simulation ApproachUsman Sumo Friend Tambunan, Mochammad Arfin Fardiansyah Nasution, Arli Aditya Parikesit et al.The drug resistance A/H1N1 flu virus is emerging rapidly. Therefore, looking for potential therapy is very important. PB2, PB and PA are subunits of viral RNA-dependent RNA polymerase (RdRp). They play an important role in viral replication. The PA and PB1 binding sites can be considered as potential targets for the development of new influenza drugs. The peptide inhibitors can … …OnLine Journal of Biological Sciences, Vol. 16, Issue 3 · 24 Aug 2016 · 7,310 accessesView PDFCite