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21 results for “autoimmune system”
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Research ArticleOpen accessIn the abstractGene Expression Profiling of Toll-Like Receptor 4 and 5 in Peripheral Blood Mononuclear Cells of Patients with Systemic SclerosisSimin Almasi, Saeed Aslani, Hadi Poormoghim et al.The Toll-Like Receptor (TLR) family is appeared to be expressed in many cell types in the immune system and plays a role in the pathogenesis of various autoimmune diseases. The expression profile and role of TLRs in Systemic Sclerosis (SSc) have been partly explained. It is aimed through this investigation to evaluate the expression pattern of TLR 4 and 5 … …American Journal of Immunology, Vol. 12, Issue 1 · 17 Mar 2016 · 7,049 accessesView PDFCite
EditorialOpen accessIn the abstractAre we Able to Harness the Immunomodulatory Power of Cytokines for Novel Autoimmune Disease Treatments?Giuseppe Nocentini, Graziella Migliorati, Carlo RiccardiSince the end of the 1970s, interleukin 2 (IL-2) has been known as a key player in T cell expansion/activation (Watson et al., 1980). In the late 1980s, some groups used IL-2 to stimulate the immune systems of tumour patients (Jacobs et al., 1986). The idea seemed brilliant and several attempts were made, but the results were disappointing (Lim et … …American Journal of Pharmacology and Toxicology, Vol. 10, Issue 2 · 22 Oct 2015 · 7,625 accessesView PDFCite
Research ArticleOpen accessIn the abstractRole of Galphaq Containing Protein in Immune RegulationYuan Liu, Lu Gan, Guixiu ShiG proteins, one of the most important transmembrane signal transducers, contain four subfamilies. Gαq is the α subunit of Gq protein subfamily. The Gαq containing protein initially attracted attention for its physiological significance is in cardiovascular system. In recent years, its role in immune regulation has been indicated. Studies domenstrated that Gαq plays crucial role in regulating both innate and … …American Journal of Immunology, Vol. 8, Issue 4 · 18 Oct 2012 · 7,417 accessesView PDFCite
Research ArticleOpen accessIn the abstractBridging from Cells to Cognition in Autism Pathophysiology: Biological Pathways to Defective Brain Function and PlasticityMatthew P. Anderson, Brian S. Hooker, Martha R. HerbertWe review evidence to support a model where the disease process underlying autism may begin when an in utero or early postnatal environmental, infectious, seizure, or autoimmune insult triggers an immune response that increases reactive oxygen species (ROS) production in the brain that leads to DNA damage (nuclear and mitochondrial) and metabolic enzyme blockade and that these inflammatory and oxidative … …American Journal of Biochemistry and Biotechnology, Vol. 4, Issue 2 · 30 Jun 2008 · 17,455 accessesView PDFCite
Research ArticleOpen accessIn the abstractImmunomodulatory Treatment of Infertility in Men with Elevated Antisperm AntibodiesIvan Bubanovic, Slobodan Kojic, Stevo Najman, Zlatibor AndjelkovicPossible causes of subfertility or infertility in men are still poorly defined, but one important category may be elevated level of antisperm antibodies (ASA) caused by infective and/or autoimmune diseases, as well as injuries of male reproductive system. In this study, blood sera from 45 infertile men of different age with ASA positive ELISA test were examined for the serum … …American Journal of Immunology, Vol. 1, Issue 4 · 31 Dec 2005 · 8,839 accessesView PDFCite
EditorialOpen accessIn the abstractGLUTATHIONE: A POSSIBLE LINK TO AUTOPHAGY IN SYSTEMIC LUPUS ERYTHEMATOSUSDilip Shah, Swapan K. NathIncreased free radical formation and altered redox state are of fundamental importance in the pathogenesis of autoimmune diseases including Systemic Lupus Erythematos (SLE). Free radicals are mainly derived from oxygen (Reactive Oxygen Species/ROS) and nitrogen (Reactive Nitrogen Species/RNS) at mitochondria, cellular membranes and the endoplasmic reticulum membrane as physiological responses to a variety of internal and external stress (Shah et … …American Journal of Immunology, Vol. 10, Issue 3 · 3 Sep 2014 · 12,773 accessesView PDFCite
Research ArticleOpen accessIn the abstractRelationship between Fetuin-A and Systemic Lupus Erythematosus as a Predictor Marker for AtherosclerosisOsama F. Mosa, Ibrahim H. Mohamad, Magdi M. SalamaProblem statement: Associations between serum levels of fetuin-A, C3 complement, calcium × phosphate product and calcification risk index and lipid profile in SLE patients were established. However, the mechanism of accelerated atherosclerosis accompanied with SLE remains elusive. We therefore turned to investigate the association between Fetuin-A, disease activity and accelerated atherosclerosis in patients with SLE. Approach: Serum blood samples were … …Current Research in Medicine, Vol. 3, Issue 2 · 15 Sep 2012 · 7,777 accessesView PDFCite
Research ArticleOpen accessIn the abstractMicrobial Translocation and B Cell Dysfunction in Human Immunodeficiency Virus DiseaseWei JiangThe gut mucosal barrier disrupted in HIV disease, resulting in increased systemic exposure to microbial products such as Lipo Polys Accharide (LPS). The association of enhanced microbial translocation and B cell dysfunction in HIV disease is not fully understood. High dose and short term exposure of microbial Toll-Like Receptor (TLR) agonists were used as vaccine adjuvants, however, low dose and … …American Journal of Immunology, Vol. 8, Issue 2 · 30 Jun 2012 · 7,409 accessesView PDFCite
Research ArticleOpen accessIn the abstractAnti-β2 Glycoprotein-I Antibody in Acute Myocardial InfarctionMohammad Shojaei, Abdolreza Sotoodeh Jahromi, Hamideh Ebadat et al.Problem statement: Ischemic cardiac manifestations have been reported in a various percentage of patients with anti-phospholipid antibodies. Data concerning the relation between anti- Phospholipid (aPL) antibodies and myocardial infarction in subjects without evidence of overt autoimmune disease are conflicting. Anti-beta2 glycoprotein-I (anti-beta2-GPI) antibody is detected in various diseases like rheumatoid arthritis, systemic lupus erythematosus and anti-phospholipid antibody syndrome. The study … …American Journal of Applied Sciences, Vol. 8, Issue 8 · 18 Jul 2011 · 7,051 accessesView PDFCite