17 results for “alloxan”

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Research ArticleOpen accessIn the keywordsConcomitant Down Regulation of Glycolytic Enzymes, Upregulation of Gluconeogenic Enzymes and Potential Hepato-Nephro-Protective Effects Following the Chronic Administration of the Hypoglycemic, Insulinotropic Citrullus colocynthis Pulp ExtractMohammad Dallak, Nabil Bashir, Mohammad Abbas et al.Background Citrullus colocynthis pulp seedless extract has been demonstrated to have antihyperglycemic and insulinotropic effects. Problem statement: The mechanism(s) underlying the antihyperglycemic and insulinotropic effects have not been investigated to date. Approach: The influence of Citrullus colocynthis pulp extract administered orally was studied in alloxan diabetic white albino rats. Rats were divided into four groups, the first group was normal … …American Journal of Biochemistry and Biotechnology, Vol. 5, Issue 4 · 31 Dec 2009 · 7,898 accessesView PDF Cite

Research ArticleOpen accessIn the keywordsIn vivo, Acute, Normo-hypoglycemic, Antihyperglycemic, Insulinotropic Actions of Orally Administered Ethanol Extract of Citrullus colocynthis (L.) Schrab PulpMahmoud Al-Khateeb, Mohammad Dallak, Fahaid Al-Hashem et al.Problem statement: Citrullus colocynthis (L.) Schrab (cucurbitaceae family) (Handal) is a fruit commonly known as bitter apple or bitter cucumber. Traditionally, Citrullus colocynthis has been used for the treatment of diabetes. In particular, the acute effect and rout of administration of ethanol extract of the seedless pulp in vivo remains untested. We investigated the effect of different routs of administration … …American Journal of Biochemistry and Biotechnology, Vol. 5, Issue 3 · 30 Sep 2009 · 8,306 accessesView PDF Cite

Research ArticleOpen accessIn the keywordsInfluence of Quercetin on Diabetes-Induced Alteration in CYP3A Activity and Bioavailability of Pioglitazone in RatsSudhir Niranjan Umathe, Pankaj Vinod Dixit, Jignesh Manubhai Vaghasiya, Nishant Sudhir JainProblem statement: Quercetin-a common bioflavonoid, is present in herbal preparations consumed by diabetic patients along with routine anti-diabetic agents. We recently showed that quercetin increases the bioavailability of pioglitazone in non-diabetic rats. Thus, present study investigated whether this pharmacokinetic interaction is also evident in diabetic animals, especially because diabetic subjects have altered gastrointestinal (GI) function and CYP3A activity. Approach: The … …American Journal of Infectious Diseases, Vol. 5, Issue 2 · 30 Jun 2009 · 7,818 accessesView PDF Cite

Research ArticleOpen accessIn the keywordsBiochemical and Immunological Study on the Effects of Barley and its Components as Hypoglycemic Agents in Diabetic RatsMokhtar I. Yousef, Medhat Haroun, Mohamed H. El-Masry, Reham EA. AteiaThe present study was carried out to investigate the hypoglycemic effect of barley (Hordeum vulgare L) and some of its components such as amino acids (L-leucine and L-glutamine) and chromium picolinate on some biochemical and immunological parameters of alloxan induced diabetic rats. Alloxan-diabetic rats were treated with barley water (10% w/v) at a dose 10 ml Kg-1 b.wt., chromium picolinate … …American Journal of Biochemistry and Biotechnology, Vol. 2, Issue 1 · 31 Mar 2006 · 7,233 accessesView PDF Cite

Research ArticleOpen accessIn the abstractPeriodic Validation of High Antidiabetic Potentials of Unripe Plantain in Comparison with Glibenclamide and FansidarE. O. Jimmy, M. A. OkonProblem statement: The antidiabetic potentials of aqueous extract of musa paradisciaca (unripe plantain fruit) were investigated in alloxan induced diabetic rats. The extract at a dosage of 120 mg kg-1 produced a significant (p<0.001) reduction in glucose level by 85% on day 7, 78% on day 14, 64% on day 21 and 44% on day 28. Approach: The extract at … …American Journal of Pharmacology and Toxicology, Vol. 7, Issue 1 · 22 Mar 2012 · 7,997 accessesView PDF Cite

Research ArticleOpen accessIn the abstractProtective Effect of Enicostemma littorale Blume on Rat Model of Diabetic NeuropathyNiraj Mukundray Bhatt, Suparna Barua, Sarita GuptaProblem statement: Poor glycemic control and oxidative stress is implicated as a common pathway in the development of diabetic neuropathy. Approach: In the present study, we investigated the protective effects of Enicostemma littorale Blume (EL) (2.5 g kg-1), a hypoglycemic and antioxidant herbal medicine in alloxan-induced diabetic neuropathy in male Charles foster rats. Results: Tail flick latency in hot immersion … …American Journal of Infectious Diseases, Vol. 5, Issue 2 · 30 Jun 2009 · 7,838 accessesView PDF Cite

Research ArticleOpen accessIn the abstractDetermination of A.C. Impedance Spectroscopic and Cyclic Voltammetric Behavior of Some Heterocarbonyl Compounds in Both Aprotic and Aqueous MediaFarouk A. RashwanThe electrochemical behavior of eosin, isatin and alloxan in aqueous KNO3 and NaClO4 solutions on the Hanging Mercury Drop Electrode [HMDE] and in aprotic DMF and CH3CN on the Pt-disk electrode at 298 K was investigated using the Cyclic Voltammetry (CV) and the Electrochemical Impedance Techniques (EIS). In the CV experiment, the electroreduction of eosin in both aqueous and non-aqueous … …American Journal of Applied Sciences, Vol. 2, Issue 7 · 31 Jul 2005 · 6,665 accessesView PDF Cite