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239 results for “Z-drugs”
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Research NotesOpen accessEvery word in the titleIndividualizing Periods of Commercial Exclusivity to Control Pricing for Drugs and BiologicsCallie M. Blase, Brandon K. Rouault, Maia B. Zoller et al.The pricing for immunologic agents and antibody-based therapeutics has increased precipitously in recent years. Among the key contributors to price hikes is the static practice of granting commercial exclusivity to innovator drugs and biologics. Herein, we present a mechanism for individualizing periods of commercial exclusivity to control pricing for drugs and biologics. …American Journal of Immunology, Vol. 15, Issue 1 · 13 Sep 2019 · 7,011 accessesView PDFCite
InvestigationOpen accessEvery word in the titleA Study of Prescribing Pattern of Drugs during Pregnancy and Lactation in the Secondary and Tertiary Care Hospitals of Bangladesh: A Cross Sectional StudyMohammad Mohasin Miah, Shakil Ahammad Mridha, Azad Md. Abu Rayhan, Afia FerdousUsing of prescribed drugs during pregnancy and lactation requires special attention because of having risk of the mothers as well as the health and life of her unborn child. Medicinal abuse usually happens due to lack of abundant information on the use of drugs during pregnancy and lactation. The main objective of this study was to assess the information about … …American Journal of Pharmacology and Toxicology, Vol. 12, Issue 4 · 5 Jan 2018 · 8,548 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleA Bayesian Adaptive Design for Combination of Three Drugs in Cancer Phase I Clinical TrialsMourad Tighiouart, Quanlin Li, Steven Piantadosi, Andre RogatkoWe describe a Bayesian adaptive design for early phase cancer trials of a combination of three agents. This is an extension of an earlier work by the authors by allowing all three agents to vary during the trial and by assigning different drug combinations to cohorts of three patients. The primary objective is to estimate the Maximum Tolerated Dose (MTD) … …Current Research in Biostatistics, Vol. 6, Issue 1 · 25 Aug 2016 · 8,421 accessesView PDFCite
Review ArticleOpen accessEvery word in the titleScope and Perspectives of New TB Drugs and VaccinesJaishree Meena, Laxman S. MeenaTuberculosis remains a major threatening infectious disease claiming millions of lives every year; hence increasing the global burden of TB disease. Co-infection with human immuno-deficiency virus and emergence of multi-drug resistant tuberculosis, extremely drug resistant tuberculosis and totally drug resistant tuberculosis enhances deadly effect of tuberculosis. To eliminate TB disease from human population several partnerships are working together like Stop … …American Journal of Infectious Diseases, Vol. 11, Issue 3 · 10 Sep 2015 · 7,943 accessesView PDFCite
EditorialOpen accessEvery word in the titleAntibacterial Quorum-Sensing Molecules as Long Lasting Antibacterial DrugsAnanya Pavuluri, Yan Zhang, Shanzhi WangAntibacterial quorum-sensing molecules are a new type of antibacterial reagent that blocks bacterial communications and dampens virulence. These molecules are proposed to tackle the roots of drug resistance and to be long lasting, although more research should be done toward the effectiveness and resistance of these drugs. …American Journal of Biochemistry and Biotechnology, Vol. 11, Issue 1 · 26 Jan 2015 · 6,925 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleEvaluation of Different Drugs in Down-Regulation of Efflux Pump Genes expression in Methicillin-Resistant Staphylococcus aureus StrainsManu Chaudhary, Santosh Kumar Patnaik, Anurag PayasiAntimicrobial resistance caused by efflux systems is not widely studied in Staphylococcus aureus. In the present study, prevalence of NorA and NorB efflux pumps was studied in thirteen Methicillin-Resistant Staphylococcus aureus (MRSA) strains using a pair of primers with Polymerase Chain Reaction (PCR). Antibiotic susceptibility study in NorA and NorB efflux positive isolates was carried out according to the Clinical … …American Journal of Infectious Diseases, Vol. 10, Issue 4 · 7 Jan 2015 · 7,451 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleDocking and Molecular Dynamics Simulations in Potential Drugs Discovery: An Application to Influenza Virus M2 ProteinMarine E. Bozdaganyan, Philipp S. Orekhov, Nicola L. Bragazzi et al.Molecular docking is a common method for searching new potential drugs. Improvement of the results of docking can be achieved by different ways-one of them is molecular dynamics simulations of protein-ligand complexes. As a model for our research we chose M2 membrane protein from influenza virus. M2 protein is a high selective tetrameric pH-gated proton channel. It was previously shown … …American Journal of Biochemistry and Biotechnology, Vol. 10, Issue 3 · 11 Nov 2014 · 8,669 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleTHE MODEL IN PREVENTING AND SOLVING DRUGS IN THE THAI-LAO BORDER VILLAGESWattana Puttichart, Saner Piromjitpong, Metta MettkarunjitA drug issue is a problem at both national and international levels. The root causes of the problems lie inside and outside the humans. To solve the problems in a sustainable way, it is essential to get cooperation from many parties. The research aimed to study the situations and prevention and solution of drugs in the border villages, to construct … …Journal of Social Sciences, Vol. 10, Issue 1 · 18 Apr 2014 · 7,494 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleA Brief Overview of the Coxib Drugs in the Veterinary FieldTae-Won Kim, Mario GiorgiTraditional Non-steroidal Anti-Inflammatory Drugs (NAIDs) have been widely used to deal with many inflammatory conditions in veterinary medicine. Nowadays however, as the quality of life of animals is improved, new drug options need to be explored. In this review, the authors report on recent trends and the application of the active ingredients labeled for veterinary purposes. …American Journal of Animal and Veterinary Sciences, Vol. 8, Issue 2 · 5 Jul 2013 · 13,852 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleOn the Hormetic Behaviour of Drugs Binding to Different Redox States of Amine Oxidase EnzymesDeepak Narang, G. Reid McDonald, David J. Smith et al.Classical monoamine oxidases and copper-containing semicarbazide-sensitive amine oxidases are drug targets for a variety of established and novel pharmaceuticals used to treat conditions such as depression, Parkinsonism and inflammatory disorders. Development of enzyme inhibitors, both historically and currently, assumes an underlying adherence of these enzymes to Michaelis-Menten kinetic principles. In this mini-review, we discuss historical data from several laboratories and … …American Journal of Pharmacology and Toxicology, Vol. 3, Issue 1 · 31 Mar 2008 · 6,928 accessesView PDFCite