Sign inSubmit
Tips: “quotes” for a phrase · author:Lee · a DOI goes straight to its article

82 articles for “Underlying Mechanism”
Set a search alert
Also matching:2 special issues
Research ArticleOpen accessIn the abstractEpigenetic Regulation of Extracellular Matrix Remodeling in Skin Aging: Mechanisms and InteractionsJiguang Yang, Yusong Shi, Xiaoqing YanSkin aging results from complex interactions between genetic factors, environmental stressors, and epigenetic modifications that regulate extracellular matrix (ECM) remodeling. Accumulation of senescent cells impairs tissue regeneration through mechanisms including telomere shortening, reactive oxygen species accumulation, and ultraviolet (UV) radiation exposure. While epigenetic pathways regulate skin homeostasis, regeneration, and senescence, the specific epigenetic changes occurring during UV exposure, chronological aging, … …American Journal of Biochemistry and Biotechnology, Vol. 21, Issue 4 · 15 Feb 2026 · 1,461 accessesView PDFCite
Research ArticleOpen accessIn the abstractDihydroartemisinin Attenuates HBV-Induced Proliferation and Migration in LO2 cells via EMT Pathway ModulationYingde Nong, Caifang Ma, Wei Huang et al.Dihydroartemisinin (DHA), a derivative of artemisinin, possesses well-documented anti-inflammatory properties. This study investigated the inhibitory effects of DHA on hepatitis B virus (HBV)-induced cellular alterations in LO2 cells and elucidated underlying molecular mechanisms. Serum interleukin-6 (IL-6) levels were measured in HBV patients and analyzed for correlations with HBsAg, anti-HBs, and HBeAg. In vitro, LO2 cells were infected with clinical HBV … …American Journal of Biochemistry and Biotechnology, Vol. 21, Issue 3 · 8 Jan 2026 · 2,079 accessesView PDFCite
Research ArticleOpen accessIn the abstractBlood-Circulating Type 2 Follicular Helper T Cells in Pediatric Allergy PatientsMasaaki Hamada, Yoshihiko Sakurai, Tomohiro TakedaPediatric allergic diseases are primarily caused by an IgE-dependent immunological reaction. Despite studies reporting the involvement of T follicular Helper (TfH) cells, especially type 2 TfH cells, in class-switching to IgE production in B cells, TfH subset skewing in peripheral blood in pediatric allergy patients remains to be elucidated. This study aimed to investigate the possible involvement of type 2 … …American Journal of Immunology, Vol. 16, Issue 1 · 18 Jun 2020 · 7,506 accessesView PDFCite
Research ArticleOpen accessIn the abstractONCODIAG Select and Test (ST) Algorithm: An Approximate Clinical Reasoning Model for Diagnosing and Monitoring Breast CancerO.N. Oyelade, A.A. Obiniyi, S.B. JunaiduClinical reasoning involves coordinated thinking strategies targeted at gathering and analyzing relevant information to arrive at a high-quality clinical solution to patients' medical problems. The correctness and proper choice of clinical reasoning approach chosen by a clinician or machine affect the accuracy and acceptability of the diagnosis; moreover, another challenge that usually surfaces during clinical reasoning is the burden of … …Current Research in Bioinformatics, Vol. 9, Issue 1 · 22 Feb 2020 · 8,942 accessesView PDFCite
Research ArticleOpen accessIn the abstractTelomere Length and Gut Microbiota: Integrating Advanced Glycation End Products (Ages) With Artificial Intelligence for Understanding Premature AgingDiniwati Mukhtar, Hanifah HafsariPremature aging is characterized by an accelerated decline in biological functions, increasing the risk of chronic diseases. This review explores the interconnected roles of three critical biomarkers: Telomere Length, gut microbiota composition, and Advanced Glycation End Products (AGEs). These biomarkers exhibit bidirectional relationships, influencing one another and contributing to the aging process. Understanding their interplay provides valuable insights into the … …OnLine Journal of Biological Sciences, Vol. 25, Issue 3 · 3 Sep 2025 · 5,623 accessesView PDFCite
Review ArticleOpen accessIn the abstractSalt Tolerance and Cultivation Challenges of Jojoba (Simmondsia chinensis): A ReviewHeba Allah Adel MohassebJojoba is considered to be salt tolerant, but little is known about the extent of its tolerance and the relative influence on ion uptake and ethylene production and other factors are affecting the mode of actions of jojoba salt tolerant. According to many research has done before including our article about the glyoxalase I gene from jojoba which exhibits moderate … …OnLine Journal of Biological Sciences, Vol. 25, Issue 2 · 12 Jun 2025 · 3,323 accessesView PDFCite
Research ArticleOpen accessIn the abstractAdding Duckweed (Lemna minor) to Local Duck Diet: Determined Based on the Performance and Heavy MetalConcentration in their MeatSyamsuhaidi, Dwi Kusuma Purnamasari, Ryan Aryadin Putra, Uhud AbdullahAn experiment was conducted to determine whether addingduckweed fertilized with bioslurry to the diet corresponds to duckperformance and heavy metal concentration in their meat. The study wasdesigned using a completely randomized design. The treatments weredifferent levels of adding duckweed as a diet component, as follows: Basalfeed (control, no duckweed, TC), basal feed +2.5% duckweed (TL1), basalfeed +5% duckweed (TL2), basal … …American Journal of Animal and Veterinary Sciences, Vol. 20, Issue 1 · 13 May 2025 · 5,847 accessesView PDFCite
EditorialOpen accessIn the abstractEditorial Commentary: Challenge of Non–AIDS-Defining Cancers (NADCs), Focusing on Trans Activation Response Element (TAR) RNA Embedding ExosomesLechuang Chen, Ge JinGlobally, 37.9 million people were living with HIV at the end of 2018 (Organization, 2018). Cancer is a major cause of mortality and morbidity in AIDS patients and chronically HIV-infected people. With the aid of combination Antiretroviral Therapy (ART), people living with HIV (PLWH) have a longer life span. However, because the virus is not completely eradicated, PLWH under antiretroviral … …American Journal of Immunology, Vol. 15, Issue 1 · 28 Nov 2019 · 6,662 accessesView PDFCite
Research ArticleOpen accessIn the abstractAnalysis of the Utility of MPT64, Drug Susceptibility Testing and Tuberculosis/Nontuberculous Mycobacteria Reverse Transcription Polymerase Chain Reaction for Tuberculosis Diagnosis and Efficiency Compared with Traditional CultureHo Keun Choi, Ga Yeon Kim, Tae Soung Kim, Jae Kyung KimDefining the molecular mechanisms underlying the dormant state of Mycobacterium tuberculosis (MTB) is essential for developing more effective treatments for tuberculosis (TB) infection. We investigated the positivity and resistance rates of TB tests on 6,174 samples referred to a single hospital. Of these, 342 cases (5.5%) were confirmed as positive by acid-fast bacilli staining, 243 cases (71.1%) were detected as … …American Journal of Biochemistry and Biotechnology, Vol. 20, Issue 4 · 5 Dec 2024 · 4,211 accessesView PDFCite
Research ArticleOpen accessIn the abstractInvestigation of the Contribution of Late Embryogenesis Abundant (LEA) K Peptide in Enhancing the Expression of Lipase from Sphingobacterium sp.: In vitro and in Silico StudiesIbrahim Muhammad et al.Sphingobacterium sp. AB3 lipase is a psychrophilic enzyme with optimal lipolytic activity at pH 7 and 15°C. The cold-adapted properties of the lipase render it suitable for various low-temperature industrial applications such as biodiesel production, detergent formulation, and non-thermal food processing. Recent studies have shown that co-expression of LEA K peptide with AB3 lipase resulted in enhanced protein expression in … …American Journal of Biochemistry and Biotechnology, Vol. 20, Issue 4 · 21 Nov 2024 · 4,572 accessesView PDFCite