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Research ArticleOpen accessEvery word in the titleLaser Therapy of Irradiated Traumatized Skeletal Muscles and State of Immune System in AnimalsNelly Bulyakova, Svetlana Zubkova, Valentina AzarovaProblems statement: This study was designed to examine the effect of laser therapy on regeneration of traumatized skeletal muscles and on dynamics of immune responses in thymus and bone marrow under ionizing radiation. Approach: After local X-ray radiation of both rat gastrocnemius muscles at a dose 20 Gy or after total γ-irradiation of animals at a semiletal dose 6 Gy, … …OnLine Journal of Biological Sciences, Vol. 11, Issue 2 · 27 Aug 2011 · 8,198 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleAAV-Based Targeting Gene TherapyWenfang Shi, Mingxia Yu, Qijun QianSince the first parvovirus serotype AAV2 was isolated from human and used as a vector for gene therapy application, there have been significant progresses in AAV vector development. AAV vectors have been extensively investigated in gene therapy for a broad application. AAV vectors have been considered as the first choice of vector due to efficient infectivity, stable expression and nonpathogenicity. … …American Journal of Immunology, Vol. 4, Issue 4 · 31 Dec 2008 · 6,960 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleStandard Versus Specific Therapy for Chronic Osteomyelitis TreatmentAngela Ingianni, Giorgio Lampis, Samuela Laconi et al.58 patients with chronic osteomyelitis were treated either with a standard therapy or with a specific targeted therapy based on the antibiogram assay. Standard therapy was performed by a 15-day course of a parenteral cephalosporin (usually ceftriaxone) in combination with an aminoglycoside (e.g. netilmicin), followed by oral therapy with a fluoroquinolone (generally ciprofloxacin) for 1 to 3 months; specific therapy … …American Journal of Infectious Diseases, Vol. 3, Issue 3 · 30 Sep 2007 · 6,874 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleSurvival Analysis of Data of HIV Infected Persons Receiving Antiretroviral Therapy Using a Model-Based Binary Tree ApproachSimon Tiendrébéogo, Blaise Somé, Séni Kouanda, Simplice Dossou-GbétéDiscrete-time approach is used in survival data analysis when only the time interval in which the event of interest has occurred is known or when this event occurs in a discrete - time scale. The work presented in this paper is motivated by the analysis of HIV/AIDS follow-up data collected in Burkina Faso during the 5-YEAR Global Fund program implemented … …Journal of Mathematics and Statistics, Vol. 15, Issue 1 · 24 Dec 2019 · 6,495 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleHigh Frequency of Stop Codons in the Human Immunodeficiency Virus-1 Protease Gene Frame in Human Immunodeficiency Virus+ Individuals with Below Detectable Levels of Plasma Viremia During Highly Active Antiretroviral TherapyMagdalena Czubala, Kabo Matlho, Maria Arriaga et al.We performed sequence analysis of HIV-1 proviral protease gene fragment (560 base pairs) amplified from ex-vivo peripheral blood mononuclear cells of 83 HIV+ individuals with Below Detectable Levels (BDL) (<20-40 RNA copies/ml plasma) and detectable levels of plasma HIV viremia while on HAART. Noteworthy was the systematic presence of stop codons identified only in the BDL group and not in … …American Journal of Infectious Diseases, Vol. 8, Issue 3 · 14 Nov 2012 · 8,073 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleLeukemia and TherapyN. B. Alitheen, S. K. Yeap, N. H. Faujan et al.Problem statement: Leukemia is a cancer which linked intimately with the immune system. It is a group of heterogenous neoplastic disorder of white blood cells characterized by the uncontrolled proliferation and block in differentiation of hematopoeitic cells. Generally, leukemia can be classified into myeloid or lymphoid referring to the type of abnormal cell found most in the blood. Approach: Many … …American Journal of Immunology, Vol. 7, Issue 4 · 27 Feb 2012 · 8,123 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleRapid Recovery of Peripheral Oxygen Saturation in Hypoxic COVID-19 Patients With Ivermectin/Doxycycline/Zinc Multidrug TherapySabine Hazan, Adriana C. Vidal, Eleftherios Gkioulekas et al.Several combination therapies for the early outpatient treatment of COVID-19 were proposed by independent research groups at the onset of the pandemic during 2020 and 2021. In this observational study, we report on the outcomes of an off-label triple combination therapy, consisting of ivermectin, doxycycline, and zinc, with adjunct vitamin C and D3 supplementation, which was used on high-risk COVID-19 … …American Journal of Infectious Diseases, Vol. 22, Issue 1 · 3 Jul 2026 · 3,374 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleNeurofeedback Therapy Meets Transformers: Rewiring Sleep Disorders Through AI-Driven EEG ModulationAmala Ann KA, Vaidhehi VSleep disorders such as insomnia, sleep Apnea, and hypersomnia significantly impair neurophysiological functioning, yet conventional treatments like Cognitive Behavioral Therapy for Insomnia (CBT-I) remain resource-intensive and difficult to personalize. This study introduces a novel AI-powered neurofeedback simulation framework designed to detect dysregulated EEG frequency band activity across sleep stages and simulate targeted interventions. A Transformer-based model serves as the core … …Journal of Computer Science, Vol. 22, Issue 2 · 3 Mar 2026 · 1,674 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleInteractivity in VR Therapy: Assessing Efficacy Across Acrophobia SeverityChiew Mei Chan, Soo See Chai, Kok Luong Goh, Sze Kiat SimVirtual Reality (VR) and Artificial Intelligence (AI) have gained popularity in medical treatments, including for acrophobia- a common but often untreated fear of heights. Traditional therapies are often expensive and complex, making VR therapy a convenient and safe alternative. This study evaluates the efficacy of an AI-augmented interactivity VR therapy for acrophobia, focusing on user satisfaction and treatment outcomes. Graded … …Journal of Computer Science, Vol. 21, Issue 5 · 16 Apr 2025 · 5,864 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleThe Effect of Gliflozin Therapy on TNF-α Secretion by Cultured Monocytes in Patients with DiabetesTatiana Vladimirovna Kirichenko, Leyla Azimovna Bochkareva et al.Currently it’s well established that chronic inflammation is a key pathogenetic mechanism in the development of Type 2 diabetes. The study aims to explore the inflammatory response of monocytes in diabetic patients compared to healthy subjects, focusing on TNF-α and to investigate the impact of SGLT2 inhibitors on monocyte inflammation. The study included 20 patients with newly diagnosed type 2 … …OnLine Journal of Biological Sciences, Vol. 24, Issue 3 · 15 Feb 2024 · 4,819 accessesView PDFCite