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20 results for “Signal Pathway”
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Research ArticleOpen accessIn the abstractSignaling Pathways Involved In Dengue-2 Virus Infection Induced RANTES OverexpressionYing-Ray Lee, Huan-Yao Lei, Shun-Hua Chen et al.Dengue viruses participate in liver inflammation by inducting the expression of various chemokines including Regulated on Activation Normal T-cell Expressed and Secreted (RANTES). However, the underlying signaling remains unknown. Here, we reveal that Ras, Raf-1 and three mitogen-activated protein kinases (MAPKs) p38, extracellular signal-regulated kinase (Erk), and c-jun-NH2-terminal kinase (JNK) can be activated or phosphorylated in dengue-2 virus infected hepatocyte … …American Journal of Infectious Diseases, Vol. 4, Issue 1 · 31 Mar 2008 · 7,173 accessesView PDFCite
Research ArticleOpen accessIn the abstractBiochemical and Genetic Responses of Fungi to the Toxic Effect of Synthetic and Natural FungicidesMarÍa-Elena Báez-Flores, Rosalba Troncoso-Rojas, Martin-Ernesto Tiznado-HernándezThe objective of the present review is to analyze the molecular basis of fungicide resistance mechanism to both synthetic fungicides and the natural fungicides isothiocyanates. The review is focused mainly on Alternaria sp., but whenever available, similar studies in other fungi have been included. Fungal resistant strains to dicarboximide and phenylpyrrole fungicides have been found to contain mutations in one … …American Journal of Agricultural and Biological Sciences, Vol. 3, Issue 1 · 31 Mar 2008 · 8,118 accessesView PDFCite
Research ArticleOpen accessIn the abstractDynamically Reconfigurable Embedded Architecture-An Alternative To Application-Specific Digital Signal Processing ArchitecturesN. Ramadass, S. Natarajan, J. Raja Paul PerinbamEmerging trends in design of real-time digital signal processing systems indicate that in the future, a significant amount of performance improvement can be achieved using dynamically reconfigurable embedded architectures consisting of reconfigurable, general-purpose components. Although embedded real-time systems have long been prevailing in our society, no firm scientific base has been established yet to handle timing requirements in a systematic … …Journal of Computer Science, Vol. 3, Issue 10 · 31 Oct 2007 · 6,727 accessesView PDFCite
Research ArticleOpen accessIn the abstractTowards Identifying Immunogenic Targets in Visceral Leishmaniasis: Role of 17kDa and 63kDa PhosphoproteinsShubhankar K Singh, Sanjiva Bimal, Diwakar S. Dinesh et al.We observed predominant phosphorylation at Protein Kinase C (PKC-α) residue in seven immunoreactive proteins of virulent Leishmania donovani parasites. These phosphoproteins were tested for their ability to stimulate T-cells for secretion of Macrophage Migration Inhibition Factor (MIF) in comparision to crude soluble antigen in Visceral Leishmaniasis (VL) patients. Two of these phosphorylated L. donovani antigens led Leishmania to present these … …American Journal of Immunology, Vol. 1, Issue 3 · 30 Sep 2005 · 6,756 accessesView PDFCite
Research ArticleOpen accessIn the abstractEffects of a Topical Composition of GABA and Microbial Chondroitin Sulfate on Mental Calmness and Brain FunctionMarco RuggieroThis article describes a novel topical composition constituted by Gamma-Aminobutyric Acid (GABA) and microbial chondroitin sulfate. This composition, formulated by the author and manufactured in a certified facility in the United States of America, exhibits potential for non-invasive intervention in anxiety management, sleep quality enhancement and promotion of brain-related functions like meditation and nonlocal consciousness. The core component comprises GABA, … …American Journal of Immunology, Vol. 19, Issue 1 · 8 Mar 2024 · 11,673 accessesView PDFCite
Research ArticleOpen accessIn the abstractEFFECT OF ZINC OXIDE NANOPARTICLES ON NEUROBLASTOMA SH-SY5Y CELLSJinghui Zheng, Theresia Schnurr, Kriya Dunlap et al.The Arctic and sub-arctic regions are impacted by the growth of the global nanotechnology industry and the transport of chemicals to the North. New nanotechnology industries, such as neural prothesis, are bringing nanomaterials in direct contact with neurons and glial cells. Nanomaterials have unique chemical and physical properties that may lead to toxicological effects by interfering with normal cellular metabolism. … …American Journal of Biochemistry and Biotechnology, Vol. 10, Issue 2 · 4 Jul 2014 · 8,488 accessesView PDFCite
Research ArticleOpen accessIn the abstractNeuronal Functions of Protein Phosphatase 2AHung-Tat Leung, Ning WangReversible protein phosphorylation is a common and important form of protein posttranslational modification which determines the proteins’ activities, substrate specificity and inhibitions or degradations, depending on the specific amino acid residue, or combination of residues, being targeted. While protein phosphorylations by kinases have been well studied, the importance of protein dephosphorylation by phosphatases has emerged over the past two decades … …Neuroscience International, Vol. 4, Issue 2 · 1 Apr 2014 · 7,777 accessesView PDFCite
Research ArticleOpen accessIn the abstractStructural and Evolutionary Analysis of PARPs in D. discoideumA. Mehadvi Kawal, Hina A. Mir, Chethan Kumar Ramniklal et al.Problem statement: Dictyostelium discoideum, a unicellular eukaryote, exhibits multicellularity upon nutrient starvation, making it a better model for developmental studies and for the study of various signal transduction pathways. The most felicitous point of interest is that many of its genes show high degree of similarity to vertebrate genes. Poly (ADP-ribose) polymerase (PARP), a ubiquitous and abundant nuclear protein, has … …American Journal of Infectious Diseases, Vol. 7, Issue 3 · 3 Nov 2011 · 7,852 accessesView PDFCite
Research ArticleOpen accessIn the abstractBridging from Cells to Cognition in Autism Pathophysiology: Biological Pathways to Defective Brain Function and PlasticityMatthew P. Anderson, Brian S. Hooker, Martha R. HerbertWe review evidence to support a model where the disease process underlying autism may begin when an in utero or early postnatal environmental, infectious, seizure, or autoimmune insult triggers an immune response that increases reactive oxygen species (ROS) production in the brain that leads to DNA damage (nuclear and mitochondrial) and metabolic enzyme blockade and that these inflammatory and oxidative … …American Journal of Biochemistry and Biotechnology, Vol. 4, Issue 2 · 30 Jun 2008 · 17,455 accessesView PDFCite
Research ArticleOpen accessIn the abstractHormesis and Exercise: How the Cell Copes with Oxidative StressLi Li Ji, Zsolt Radak, Sataro GotoContraction-induced production of reactive oxygen and nitrogen species has been shown to cause oxidative stress to skeletal muscle, heart and other organs. As an adaptive response, muscle antioxidant defense systems are upregulated in response to exercise to restore intracellular prooxidantantioxidant homeostasis. Thus, both young and old animals and humans involved in regular exercise have shown reduced oxidative damage during acute … …American Journal of Pharmacology and Toxicology, Vol. 3, Issue 1 · 31 Mar 2008 · 7,817 accessesView PDFCite