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26 results for “Safety profile”
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HypothesisOpen accessIn the abstractCJ-023,423 (Grapiprant) a Potential Novel Active Compound with Antihyperalgetic Properties for Veterinary PatientsMario GiorgiCompanion animals are now living longer and so are more commonly manifesting age- and pain-related disease. Nonsteroidal anti-inflammatory drugs are the most used drug in osteoarthritis and inflammatory pain of various aetiologies. Despite their safety profiles have been amended from the COX-non selective to the COX-2 selective inhibitor class, some adverse effects are still of concern especially in long term … …American Journal of Animal and Veterinary Sciences, Vol. 10, Issue 2 · 14 May 2015 · 8,874 accessesView PDFCite
Research ArticleOpen accessIn the abstractGastroprotective Effect and Safety Assessment of Zanthoxylum Zanthoxyloides (Lam) Waterm Root Bark ExtractAlex Boye, George Asumeng Koffuor, Johnson Nyarko Boampong et al.Problem statement: Gastrointestinal ulcers account significantly for morbidity and mortality in Ghana. The study therefore investigated the gastroprotective effect of an ethanolic root bark extract of Zanthoxylum zanthxyloides and its safety for us. Approach: Gastric ulceration was induced in Sprague-Dawley rats with Indomethacin (25 mg kg-1, p.o) and was treated with 150, 250, or 500 mg kg-1 of the extract, … …American Journal of Pharmacology and Toxicology, Vol. 7, Issue 2 · 7 Aug 2012 · 8,495 accessesView PDFCite
Research ArticleOpen accessIn the abstractUncommon Toxicologic Profile at Toxic Doses of CPI-613 (an Agent Selectively Alters Tumor Energy Metabolism) in Rats and Minipigs Reflects Novel MechanismClaudia Maturo, King C. Lee, Robert Rodriguez, Robert ShorrProblem statement: CPI-613 is a novel anticancer agent and the toxicological profile has not been assessed. Accordingly, the objective of these studies was to thoroughly evaluate the Toxicokinetic (TK) effects of CPI-613 in rats and to compare the toxicological profile of rats to minipigs to determine if there were differences between the two animal species. Approach: These studies involved assessments … …American Journal of Pharmacology and Toxicology, Vol. 5, Issue 4 · 13 Jun 2011 · 9,582 accessesView PDFCite
Review ArticleOpen accessIn the abstractTrazodone: A Review of Its Pharmacological Properties and Its Off-Label Use in Dogs and CatsBunna Chea, Mario GiorgiTrazodone is approved by the Food and Drug Administration (FDA) for the treatment of depression and anxiety in humans, it can perform these functions due to its selective serotonin receptor antagonism and reuptake inhibition properties. Trazodone has not been approved for animals by the FDA but it is legally prescribed by veterinarians as an off-label drug for dogs and cats. … …American Journal of Animal and Veterinary Sciences, Vol. 12, Issue 4 · 31 Oct 2017 · 10,858 accessesView PDFCite
Research ArticleOpen accessIn the abstractDetermination of the Probiotic Potential and Metabolic Function of Lactobacillus Strains for Healthy Calf RearingRaya Myktybayeva, Serkan Özkaya, Elif Rabia Şanlı et al.This research investigstes the impact of probiotic supplementation on the growth performance, health status, and physiological traits in Holstein calves. A total of thirty calves were randomly divided into three experimental groups: a control group and two treatment groups receiving probiotics at doses of 1 g/10 kg and 1.5gt/10 kg live weight. Key indicators, including Live Weight (LW), Body Measurements … …OnLine Journal of Biological Sciences, Vol. 25, Issue 3 · 23 Jul 2025 · 3,626 accessesView PDFCite
Research ArticleOpen accessIn the abstractRISK-BENEFIT ANALYSIS AND RISK MINIMIZATION OF QUINAPRIL: A REVIEWAnjo Sunny, M. Arif Khan, Darpelly Mahesh et al.The purpose of this review is to give the readers an insight about the risks and benefits of ’quinapril’, a potent Angiotensin Converting Enzyme Inhibitor (ACEI). Quinapril is a highly effective novel drug indicated for treatment of congestive heart failure and hypertension. Despite of the fact that safety profile is quite well with low incidence of adverse effects, an attempt … …American Journal of Pharmacology and Toxicology, Vol. 9, Issue 1 · 12 Feb 2014 · 7,254 accessesView PDFCite
Research ArticleOpen accessIn the abstractRecent Clinical Advancement of the Effects of Parathyroid Analogues on Fracture Healing in Humans: A Review of LiteratureWen Wei Gerard Ee, Wen Liang Joel Lau, Harish Sivasubramanian, Diarmuid MurphyProblem statement: Numerous animal studies have shown that administration of Parathyroid Hormone (PTH) or a related analogue promotes callus formation and bone union. However, there has yet to be sufficient evidence in human subjects to justify the use of PTH or related analogues in promoting fracture healing. The purpose of this paper is to (1) review all literature involving the … …Current Research in Medicine, Vol. 3, Issue 2 · 27 Aug 2012 · 7,338 accessesView PDFCite
Research ArticleOpen accessIn the abstractAnalysis of Salmonella enteritidis Outer Membrane Proteins and Lipopolysaccharide Profiles with the Detection of Immune Dominant ProteinsA. Maripandi, Ali A. Al-SalamahProblem statement: Salmonella infection is a serious medical and veterinary problem world-wide and causes great concern in the human health and food safety. Salmonella enteritidis outer membrane proteins and lipopolysaccharide play important role in the virulence and immunological properties of bacteria. Prophylaxis of enterobacterial infection has proven difficult to achieve. Vaccination is an effective tool for the prevention of Salmonella … …American Journal of Immunology, Vol. 6, Issue 1 · 21 Jun 2010 · 9,147 accessesView PDFCite
Research ArticleOpen accessIn the abstractImpact of Takeoff Angle of Bucket Type Energy Dissipater on Scour HoleNor Azlina Alias, Thamer Ahmed Mohamed, Abdul Halim Ghazali, Megat Johari Megat Mohd. NoorScour holes formed downstream of bucket type energy dissipater may affect the safety and stability of the structure. In this study, a physical model is employed to study the impact of takeoff angle of bucket type energy dissipater on the scour hole. The area of longitudinal profile of the scour hole is used to evaluate the seriousness of the scour … …American Journal of Applied Sciences, Vol. 5, Issue 2 · 28 Feb 2008 · 8,380 accessesView PDFCite
Research ArticleOpen accessIn the abstractSubacute Toxicity of Crocus Sativus L. (Saffron) Stigma Ethanolic Extract in RatsDaryoush Mohajeri, Ghafour Mousavi, Mehran Mesgari et al.The medicinal properties attributed to Crocus sativus L. (saffron) are extensive. The safety of saffron is important in relation to its medicinal applications. This study was performed to elucidate the possible toxic effects of ethanolic extract of Crocus sativus L. stigma on liver, kidney and some hematological parameters in rats. Wistar rats were randomly assigned into four groups of eight … …American Journal of Pharmacology and Toxicology, Vol. 2, Issue 4 · 31 Dec 2007 · 8,562 accessesView PDFCite