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36 articles for “Regulatory T Cell”
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EditorialOpen accessIn the abstractFocalize the Structure of Myd88 in TLR Signaling Pathway to Modulate Innate Immune Response: New Target for Old DiseasesShuai Xing, Ping ZhouAll diseases have their Achilles’ Heel to target and this is especially true for immunorelated diseases which must be treated by targeting the immune system somewhere and somehow correctly. In the most recent decade, immunologists recognized that the Toll-Like Receptor (TLR) signaling pathway in innate immune system plays a double-edged role in the pathogenesis of many notorious diseases. Although the … …American Journal of Immunology, Vol. 13, Issue 3 · 6 Sep 2017 · 7,865 accessesView PDFCite
Research ArticleOpen accessIn the abstractChronic Mental Stress Induces Reversible Reduction of Natural Killer Cells and CD56dim SubpopulationManar M. IsmailGenerally, studying to be a health care provider is a stressful and demanding field and the students have to face many stressors that may affect their general health status including the immune system. This work aimed at studying the effect of prolonged naturalistic life-stress exposure on the percentage of peripheral blood T-lymphocytes and Natural Killer (NK) cells in female laboratory … …American Journal of Immunology, Vol. 13, Issue 3 · 30 Aug 2017 · 7,794 accessesView PDFCite
EditorialOpen accessIn the abstractChasing the Fat Demon: Fat Chance, Buddy?David L. Katz, Joachim Storsberg, Christian SchmidtScience is an interesting profession. At times, one could get caught up in his or her own world of thoughts, perception, far away from reality, sometimes referred to as the proverbial ivory tower (Lederberg, 1972). Science for the sake of science is, per se, not without merit, with our fragmented understanding of a given issue providing ample justification for experimentation … …American Journal of Immunology, Vol. 13, Issue 2 · 29 May 2017 · 8,137 accessesView PDFCite
Research ArticleOpen accessIn the abstractHumoral and Cellular Effects of Stress-An Extensive Model SystemMazal Shimon-Hophy, Ramy R. AvtalionThe influence of stress on the immune system of the common carp (Cyprinus carpio) was studied by measuring leukocytes levels using flow cytometry and mRNA immune components by real time qPCR. Acute and chronic oxidative stresses were generated by different regimes of exposure of carp to environmental air. In acute stress, induced by single air exposure, the pro-inflammatory cytokines (IL1β, … …American Journal of Immunology, Vol. 13, Issue 2 · 18 Apr 2017 · 6,728 accessesView PDFCite
Review ArticleOpen accessIn the abstractThe Triple Immune Argument; Surveillance/Evasion/ Senescence and the Increased Incidence of Acute Myeloid Leukemia Observed with AgeManar M. IsmailAML originates from genetic insults of hematopoietic stem and progenitor cells (HSPCs/HSCs) that was identified earlier as leukemia stem cells (LSCs). In quiescent state, trafficking immune cells are crucial for eradication of aberrant clones and obtaining balance between proliferation and apoptosis to maintain HSCs pool. Regulatory T-cells shield the HSCs from the inflammatory reactions by suppressing T- and B- cells. … …American Journal of Immunology, Vol. 13, Issue 4 · 22 Dec 2017 · 7,807 accessesView PDFCite
EditorialOpen accessIn the abstractAre we Able to Harness the Immunomodulatory Power of Cytokines for Novel Autoimmune Disease Treatments?Giuseppe Nocentini, Graziella Migliorati, Carlo RiccardiSince the end of the 1970s, interleukin 2 (IL-2) has been known as a key player in T cell expansion/activation (Watson et al., 1980). In the late 1980s, some groups used IL-2 to stimulate the immune systems of tumour patients (Jacobs et al., 1986). The idea seemed brilliant and several attempts were made, but the results were disappointing (Lim et … …American Journal of Pharmacology and Toxicology, Vol. 10, Issue 2 · 22 Oct 2015 · 7,629 accessesView PDFCite
Research ArticleOpen accessIn the abstractThe Hypoxia-Inducible Factor-1α Signaling Pathway and its Relation to Cancer and ImmunologyBruno R.B. Pires, Andre L. Mencalha, Gerson M. Ferreira et al.Hypoxia-Inducible Factor 1 (HIF-1) is a transcription factor that is present in all metazoans from early embryonic development throughout adult life. It plays a major roles in the different stress responses that are triggered by low Oxygen (O2) levels and its expression is associated with cell survival. HIF-1 is a heterodimer protein that comprises the subunits HIF-1α and HIF-1β. The … …American Journal of Immunology, Vol. 10, Issue 4 · 17 Jan 2015 · 8,485 accessesView PDFCite
EditorialOpen accessIn the abstractGLUTATHIONE: A POSSIBLE LINK TO AUTOPHAGY IN SYSTEMIC LUPUS ERYTHEMATOSUSDilip Shah, Swapan K. NathIncreased free radical formation and altered redox state are of fundamental importance in the pathogenesis of autoimmune diseases including Systemic Lupus Erythematos (SLE). Free radicals are mainly derived from oxygen (Reactive Oxygen Species/ROS) and nitrogen (Reactive Nitrogen Species/RNS) at mitochondria, cellular membranes and the endoplasmic reticulum membrane as physiological responses to a variety of internal and external stress (Shah et … …American Journal of Immunology, Vol. 10, Issue 3 · 3 Sep 2014 · 12,777 accessesView PDFCite
Research ArticleOpen accessIn the abstractMelanoma-Associated Suppression of the Dendritic Cell Lines DC2.4 and JawsiiKristian Michael Hargadon, Yonathan Tarekegne Ararso, Osric Anthony Forrest, Chad Mason HarteDendritic cells function as potent regulators of both innate and adaptive immunity to tumors and the regulatory activities of these cells are tightly linked to their maturation and activation status. Despite the critical role played by dendritic cells in the induction of anti-tumor immune responses, the number of dendritic cells that can be isolated from experimental animals is limiting and … …American Journal of Immunology, Vol. 8, Issue 4 · 3 Nov 2012 · 9,567 accessesView PDFCite
Research ArticleOpen accessIn the abstractStructural and Evolutionary Analysis of PARPs in D. discoideumA. Mehadvi Kawal, Hina A. Mir, Chethan Kumar Ramniklal et al.Problem statement: Dictyostelium discoideum, a unicellular eukaryote, exhibits multicellularity upon nutrient starvation, making it a better model for developmental studies and for the study of various signal transduction pathways. The most felicitous point of interest is that many of its genes show high degree of similarity to vertebrate genes. Poly (ADP-ribose) polymerase (PARP), a ubiquitous and abundant nuclear protein, has … …American Journal of Infectious Diseases, Vol. 7, Issue 3 · 3 Nov 2011 · 7,855 accessesView PDFCite