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Research ArticleOpen accessEvery word in the titleA SHORT INTERFERING RNA MOLECULAR BEACON FOR THE ATTENUATION OF MYCOBACTERIAL INFECTIONRemo George, Kathy Nugent, Norman Bolus et al.The ability of the pathogen Mycobacterium Tuberculosis (MTB) to invade and survive within macrophages of granulomas is attributed to the product of the Mammalian Cell Entry (MCE) operon whose gene, mce4A, encodes a cholesterol transporter that transports host lipids into the bacterium that allows the bacterium to survive during chronic infection. Here, we proposed and tested the hypothesis that a … …American Journal of Biochemistry and Biotechnology, Vol. 10, Issue 1 · 4 Mar 2014 · 7,774 accessesView PDFCite
Review ArticleOpen accessIn the keywordsAdvances in Modern Biotechnological Tools for Sustainable Control of Plant Viral DiseasesNabela Akter, Ankita Saha, Md. Abdullah Al Sabbir, Md. Motaher HossainPlant viruses pose a major threat to global food production, causing yield losses across many staple and horticultural crops. Conventional breeding for resistance is typically slow and constrained by the number of available natural resistance genes. Recent breakthroughs in biotechnology have enabled the development of accurate, flexible, and environmentally friendly technologies to confer virus resistance. This review summarizes exciting developments … …OnLine Journal of Biological Sciences, Vol. 26, Issue 2 · 16 Jul 2026 · 726 accessesView PDFCite
Research ArticleOpen accessIn the keywordsExpression of Exosome-Derived MicroRNAs miR-21 and miR-135 are Differentially Regulated Among Dental Pulp Stem CellsMatthew Hunsaker, Brandon Richards, Adelle Fuller et al.Dental Pulp Stem Cells (DPSCs) are a type of mesenchymal stem cell that has the potential to differentiate into various types of cells and tissue. Previous research has demonstrated that DPSCs can be easily accessed and isolated from both permanent and deciduous teeth, such as wisdom teeth or third molars, although there is less information available about the mechanisms and … …Current Research in Medicine, Vol. 11, Issue 1 · 10 Jan 2023 · 10,533 accessesView PDFCite
Review ArticleOpen accessIn the keywordsDecoding Late Blight of Potato and Tomato: Insights into Pathogen Dynamics, Host Interactions and Emerging SolutionsHumayra Ferdus, Mahabuba Mostafa, Dodi Al Sharif, Md. Motaher HossainThe oomycete Phytophthora infestans is the source of late blight, a devastating disease that significantly impacts on tomato and potato cultivation worldwide, threatening food security and causing considerable economic losses. This review explores the epidemiological dynamics of late blight, focusing on the pathogen's life cycle, reproductive strategies, and molecular pathogenesis. Traditional management strategies, including cultural practices, host resistance, and biocontrol … …OnLine Journal of Biological Sciences, Vol. 25, Issue 4 · 5 Feb 2026 · 2,530 accessesView PDFCite
Letter to the EditorOpen accessIn the keywordsSofosbuvir May be a Potential Anti-SARS-CoV-2 RdRp DrugMohamed Nabil Ibrahim, Abdo Abdellah ElfikyThe Coronavirus Diseases 2019 (COVID-19) seriously affecting human health all over the world. More than 107 M people are reported positive for SARS-CoV-2, the virus causing COVID-19 pneumonia, from which +2.3 M died. Nucleotide Inhibitors (NI) have promising results in terms of its efficacy against different viral polymerases, including the Hepatitis C Virus (HCV) Non-Structural Protein 5 B (NS5B) RNA … …American Journal of Biochemistry and Biotechnology, Vol. 17, Issue 2 · 10 May 2021 · 6,568 accessesView PDFCite
Research ArticleOpen accessIn the keywordsEffects of ced-9 dsRNA on Caenorhabditis elegans and Meloidogyne incognitaRobert T. Gaeta, Abdellatif Bahaji, Glenda W. Polack, Alejandro Calderón-UrreaAbstract: Problem Statement: In metazoans Programmed Cell Death (PCD) is essential for proper development. Suppression of PCD is needed to guarantee cell survival and in the nematode Caenorhabditis elegans the regulation of PCD is accomplished by the function of the ced-9 gene. Approach: In this work the use of double stranded RNA (dsRNA) to knock-down ced-9 gene function was tested … …American Journal of Agricultural and Biological Sciences, Vol. 6, Issue 1 · 15 Dec 2010 · 9,452 accessesView PDFCite
Research ArticleOpen accessIn the keywordsInhibition of U6 snRNA Transcription by PTENStephanie Cabarcas, Kounosuke Watabe, Laura SchrammProblem statement: RNA polymerase III (RNA pol III) is responsible for transcribing many of the small structural RNA molecules involved in RNA processing and protein translation, thereby regulating the growth rate of a cell. RNA pol III transcribes both gene internal (tRNA) and gene external (U6 snRNA) promoters and proper initiation by RNA polymerase III requires the transcription initiation factor … …OnLine Journal of Biological Sciences, Vol. 10, Issue 3 · 30 Sep 2010 · 8,551 accessesView PDFCite
Research ArticleOpen accessIn the keywordsA Survey of Compute Intensive Algorithms for Ribo Nucleic Acids Structural DetectionRa’ed Al-Khatib, Rosni Abdullah, Nur’Aini Abdul RashidProblem statement: Finding an accurate RNA structural alignment from primary sequence due to it is time consuming and computationally NP-hard problem is a major bioinformatics challenge. According to our investigation majority of current researches were concerned on achieving faster execution time, improving space complexity and better cache management. Recently one research introduced cache-efficient Chip Multiprocessor (CMP) algorithms with good speed-up … …Journal of Computer Science, Vol. 5, Issue 10 · 31 Oct 2009 · 6,458 accessesView PDFCite
Research ArticleOpen accessIn the keywordsBiomedicine and Informatics Model of Alzheimer's DiseaseKang Cheng, Chang-Hua ZouIn a perspective of biomedicine and informatics, the mechanism of Alzheimer's, senile amnesia, or other aging-associated and cognitive impairment related diseases involve four important informative processing procedures: propagation, consolidation, retrieval and cognition, In this study, we systematically model the four procedures based on published experimental data. When modeling the propagation, we develop an equivalent circuit of biological membrane to describe … …American Journal of Biochemistry and Biotechnology, Vol. 3, Issue 3 · 28 May 2007 · 6,824 accessesView PDFCite
Research ArticleOpen accessIn the keywordsThe Meaning of a Redundant Codon: There is Protein Folding Information in Nucleic Acids in Addition to the Genetic CodeJan C. Biro, Josephine M.K. BiroAll the information necessary for protein folding is supposed to be present in the amino acid sequence. It is still not possible to provide specific ab initio structure predictions by bioinformatical methods. It is suspected that additional folding information is present in protein coding nucleic acid sequences, which is not represented by the known genetic code. Nucleic acid subsequences comprising … …American Journal of Biochemistry and Biotechnology, Vol. 2, Issue 1 · 31 Mar 2006 · 8,292 accessesView PDFCite