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Research ArticleOpen accessEvery word in the titleThe Financial Behavior of Jordanian Pharmaceutical IndustryMamoun Yasien ShakatrehThe study aims to analyze the financial behavior of the Jordanian pharmaceutical industry companies listed in Amman Stock Exchange (ASE) during the period 2005-2015. The study examines the relationship between funding sources and the Return on Equity (ROE) in order to reach conclusions and to make recommendations to enhance the performance of the Jordanian pharmaceutical industry companies. The Generalized Least … …American Journal of Economics and Business Administration, Vol. 11, Issue 1 · 12 Nov 2018 · 8,287 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleATLCEP: A New Integrated Design that Encompasses the Safety and Efficacy Objectives of Phase I/II TrialsRevathi Ananthakrishnan, Stephanie Green, Mark Chang et al.Several designs, such as designs to find the optimal biological dose, the Eff-Tox design and seamless Phase I/II designs, have been proposed to evaluate both drug toxicity and efficacy as alternatives to the traditional paradigm of a stepwise drug development approach. Here, we first examine the effect of sample and cohort size on the accuracy of dose selection in early … …Current Research in Biostatistics, Vol. 7, Issue 2 · 7 Apr 2018 · 7,980 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleQuercetin Promotes the Expression of Genes Involved in Phagocytosis in Bovine NeutrophilsSuphakit Srikok, Sukij Nambut, Kanruethai Wongsawan, Phongsakorn ChuammitriThis study was conducted to explore the effect of Quercetin (QH) on phagocytosis of bovine neutrophils. Neutrophils were isolated from fifteen multiparous Holstein cows. We in vitro treated neutrophils with PBS or 50 µM of Quercetin (QH) or Cytochalasin B (CytB), as phagocytosis inhibitor, prior to monitoring phagocytosis of Escherichia coli by flow cytometry and microscopic examination. Additionally, the expressions … …American Journal of Animal and Veterinary Sciences, Vol. 12, Issue 2 · 2 Aug 2017 · 8,120 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleMulti-Phase Support Vector Regression Soft Sensor for Online Product Quality Prediction in Glutamate Fermentation ProcessRongjian Zheng, Feng PanGlutamate fermentation is inherently nonlinear, multi-phase and an aerobic fermentation process. As long measurement delays and expensive apparatus cost, on-line measurement of the product concentration is not necessarily available. The present fermentation process monitoring and quality prediction involve manual interpretation of highly informative, however, the concentrations of substrates, biomass and products are only low frequency off-line measurements. In this paper, … …American Journal of Biochemistry and Biotechnology, Vol. 13, Issue 2 · 6 Jun 2017 · 8,067 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleDirect Analysis of Six Pharmaceuticals using Online Solid Phase Extraction Liquid ChromatographySiti Norbayu Mohd Subari, Rozita Osman, Norashikin SaimIn this study, three parameters (sample volume, cleanup and elution step) in large volume injection online Solid Phase Extraction Liquid Chromatography with diode array detection (SPE-LC) were optimized for the determination of six pharmaceuticals in wastewater samples. Preconcentration and separation were carried out using 2 columns, Dionex Ion Pac AG14A and Acclaim Polar Advantage II. Response Surface Methodology (RSM) was … …American Journal of Applied Sciences, Vol. 14, Issue 5 · 31 Mar 2017 · 7,513 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleSelf Medication with Antibiotics among Medical and Pharmacy Students in North IndiaBiplab Pal, Krishna Murti, Ashok Kumar Gupta et al.Self medication practices among the medical and paramedical professionals have been reported in many countries, however, very limited research was done exclusively on antibiotic in North India. This study was designed to assess the prevalence and pattern of antibiotic usage for self diagnosed diseases among the medical and pharmacy students. This was a questionnaire based cross sectional study conducted among … …Current Research in Medicine, Vol. 7, Issue 2 · 30 Dec 2016 · 13,702 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleA Bayesian Adaptive Design for Combination of Three Drugs in Cancer Phase I Clinical TrialsMourad Tighiouart, Quanlin Li, Steven Piantadosi, Andre RogatkoWe describe a Bayesian adaptive design for early phase cancer trials of a combination of three agents. This is an extension of an earlier work by the authors by allowing all three agents to vary during the trial and by assigning different drug combinations to cohorts of three patients. The primary objective is to estimate the Maximum Tolerated Dose (MTD) … …Current Research in Biostatistics, Vol. 6, Issue 1 · 25 Aug 2016 · 8,421 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleDevelopment of Phage Display Technology: A Bibliometric AssessmentAlexander Ilyichev, Larisa Karpenko, Vadim Gureyev, Nikolay MazovThe paper presents results of bibliometric analysis of papers on phage display technology written in the past 30 years. More than 2000 Scopus-indexed papers have been published in 638 journals. 73.95% papers were published by 10 most productive countries out of 58: The USA, China, Great Britain, Germany, Japan, the Netherlands, Switzerland, Italy, France and Australia. Rapid growth in scholarly … …OnLine Journal of Biological Sciences, Vol. 16, Issue 1 · 11 Jan 2016 · 7,613 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleEffect of In Vitro Nitrogen Nutrition to Phalaenopsis deliciosa Seedling GrowthChieh Wean Choong, Chin Hao Lim, Zherui Xiong, Siew Mee ChoongIn a continuous effort to conserve Phalaenopsis species, the optimization of a previously designed defined medium was carried out to understand the effect of in vitro nitrogen nutrition on Phalaenopsis deliciosa Rchb.f. In order not to alter the nutrient balance, macronutrient level instead of solely Nitrogen (N) was adjusted. Seedlings were obtained from in vitro germination and randomly inoculated on … …OnLine Journal of Biological Sciences, Vol. 16, Issue 1 · 16 Dec 2015 · 7,824 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleInfluence of Two-Phase Liquid-Gas Flow on Permeate Flux through Ceramic MembranesTomáš Bakalár, Milan Búgel, Gabriel Müller, Štefan SaboThe impact of two-phase flow onto the flux of the permeate in microfiltration of two sorbents-Bentonite and Lewatit S1468-with and without adsorbed zinc, was examined. Two different types of membrane, single-and multi-channel, based on α-Al2O3, were used. In single-channel membrane application of aeration increased the permeate flux by 13 and 29% without adsorbed zinc and by 22 and 25% with … …American Journal of Applied Sciences, Vol. 12, Issue 12 · 10 Dec 2015 · 6,765 accessesView PDFCite