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45 results for “Interleukin-10”
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Research ArticleOpen accessIn the keywordsMountain Sheep: An Environmental Epidemiological Survey of Variation in Metal Exposure and Physiological Biomarkers Following Mine DevelopmentLawrence K. Duffy, Michael W. Oehler, R. Terry Bowyer, Vernon C. BleichProblem Statement: Anthropogenic activities, such as mining and industrial operations, are a major environmental source of metal exposure for wildlife. Quantitative data regarding biochemical effects of exposure to mineral extraction on mountain sheep, Ovis canadensis, are limited, although their habitats are becoming increasingly affected by expanded resource development. Decisions relating to environmental protection and wildlife conservation should be based on … …American Journal of Environmental Sciences, Vol. 5, Issue 3 · 30 Jun 2009 · 6,654 accessesView PDFCite
Research ArticleOpen accessIn the keywordsProduction and Roles of Glial Tissue Inhibitor of Metalloproteinases-1 in Human Immunodeficiency Virus-1-Associated Dementia Neuroinflammation: A ReviewC. Chao, A. GhorpadeProblem statement: Tissue Inhibitor of Metalloproteinases-1 (TIMP-1) and its cognate targets, the Matrix Metalloproteinases (MMPs), were differentially expressed in human brain samples with or without HIV-1 infection or HIV-1 Encephalitis (HIVE). Approach: A through literature review demonstrated that cell culture models of Central Nervous System (CNS) cell types had been used to illustrate the intricate temporal patterns of TIMP-1/MMP expression, … …American Journal of Infectious Diseases, Vol. 5, Issue 4 · 31 Dec 2009 · 6,953 accessesView PDFCite
Research ArticleOpen accessIn the abstractEffect of Metformin Treatment on Inflammatory Factors and Gut Microbial Diversity in Patients with Type II Diabetes MellitusLei Tong, Jingjing Zhang, Li Xiao Yue et al.With the persistent rise in the prevalence of Type 2 Diabetes Mellitus (T2DM), traditional treatment evaluations have primarily focused on glycemic control, often overlooking the multidimensional effects of medications. As a first-line therapeutic agent, the anti-inflammatory effects and gut microbiota regulation mechanisms of metformin remain incompletely elucidated. This prospective cohort study established a metformin treatment group and a T2DM control … …American Journal of Biochemistry and Biotechnology, Vol. 22, Issue 2 · 20 Jul 2026 · 774 accessesView PDFCite
Research ArticleOpen accessIn the abstractDihydroartemisinin Attenuates HBV-Induced Proliferation and Migration in LO2 cells via EMT Pathway ModulationYingde Nong, Caifang Ma, Wei Huang et al.Dihydroartemisinin (DHA), a derivative of artemisinin, possesses well-documented anti-inflammatory properties. This study investigated the inhibitory effects of DHA on hepatitis B virus (HBV)-induced cellular alterations in LO2 cells and elucidated underlying molecular mechanisms. Serum interleukin-6 (IL-6) levels were measured in HBV patients and analyzed for correlations with HBsAg, anti-HBs, and HBeAg. In vitro, LO2 cells were infected with clinical HBV … …American Journal of Biochemistry and Biotechnology, Vol. 21, Issue 3 · 8 Jan 2026 · 2,071 accessesView PDFCite
Research ArticleOpen accessIn the abstractMolecular Characterization and in Silico Analysis of Phytochemical Compounds from Plants with Immunomodulatory PotentialHermin Pancasakti Kusumaningrum, Rejeki Siti Ferniah, Siti Nur Jannah et al.The immune system works to protect the body against foreign antigens from microorganisms and abnormal cells. The use of herbal plants as immunomodulators are used to prevent disease attacks. TNFα and interleukin-6 are pro-inflammatory immune systems that cause disease in uncontrolled synthesis. Herbal plants as inhibitors of TNFα and interleukin-6 need to be identified molecularly to reduce the occurrence of … …OnLine Journal of Biological Sciences, Vol. 25, Issue 3 · 27 Nov 2025 · 1,954 accessesView PDFCite
Research ArticleOpen accessIn the abstractEvaluating the Hepatoprotective and Anti-Inflammatory Efficacy of Herbal Extracts for NAFLD PreventionHessah Mohammed Al-Muzafar, Kamal Adel AminNatural products may offer a safer approach for mitigating the increasing prevalence of Non-Alcoholic Fatty Liver Disease (NAFLD). This study aimed to evaluate the hepatoprotective and anti-inflammatory effects of a water-based extract of Moringa Oleifera leaf, Milk Thistle, and Cassia (MO-MT-CA) against High-Fat, High-Sugar Diet (HFSD)-induced fatty liver. The research focuses on assessing lipid profiles and inflammation as key markers … …OnLine Journal of Biological Sciences, Vol. 25, Issue 3 · 23 Nov 2025 · 1,968 accessesView PDFCite
Research ArticleOpen accessIn the abstractEffects of Atorvastatin on Oxidized Low-Density Lipoprotein-induced Proliferation, Apoptosis, and Matrix Metalloproteinase-9 Expression in Human MacrophagesBensheng Liu, Huifan Li, Yan Wang, Li ZhangAtorvastatin (ATV), an HMG-CoA reductase inhibitor, is utilized in the treatment of atherosclerotic diseases. Mononuclear Macrophages (MMs) are critical immune cells involved in atherosclerosis progression, participating in processes such as foam cell formation, cytokine secretion, and the development of fibrous cap and lipid core. To further elucidate the mechanism by which ATV exerts its therapeutic effects on atherosclerosis through the … …American Journal of Biochemistry and Biotechnology, Vol. 21, Issue 3 · 18 Nov 2025 · 2,133 accessesView PDFCite
Research ArticleOpen accessIn the abstractInflammatory Effects of Co-Exposure to Heavy Metals (Cd and Pb) and Respiratory Viruses (229E, OC43, and H3N2) on IL-6 and IL-8 Responses in U87 Glioblastoma CellsHyeokjun Yun, Qian-Wen Wang, Jae Kyung KimCo-exposure to heavy metals and viruses can pose threats to cellular health by increasing cytotoxicity and inflammatory cytokine expression. We aimed to elucidate the interactions between these factors inhuman glioblastoma cells (U87). U87 cells were exposed to influenza A virus (H3N2), coronaviruses OC43 and 229E, and heavy metals Cd and Pb. Cell viability and cytotoxicity were assessed through WST-8 and … …American Journal of Biochemistry and Biotechnology, Vol. 21, Issue 2 · 5 Jul 2025 · 5,505 accessesView PDFCite
Research ArticleOpen accessIn the abstractA Sled Dog Model for Positive Health Effects of Weight Management and ExerciseLaura Falkenstein, Scott Jerome et al.Obesity is a significant risk factor for metabolic syndrome and type II diabetes. Physical activity and/or dietary modification can reduce the incidence of obesity. Marginal fitness levels limit the efficacy of exercise training, and most humans choose from a wide range of dietary strategies to lose weight. Despite these limitations, exercise in the absence of weight loss may offer protective … …American Journal of Biochemistry and Biotechnology, Vol. 19, Issue 1 · 23 Feb 2023 · 6,151 accessesView PDFCite
Research ArticleOpen accessIn the abstractEarly Responses of Neural Cells (U87) to Particulate Matter Exposure: Cell Viability and Cytokine ConcentrationJae-Sik Jeon, Eun Ju Oh, Qian-Wen Wang, Jae Kyung KimParticulate Matter (PM) has a significant impact on human health and increases the risk of respiratory diseases. PM exposure is linked to various illnesses, including cardiovascular diseases, cancer, neurological diseases, and pregnancy complications, and contributes to both mortality and morbidity globally. PM can also influence the autonomic nervous system. The evidence suggests that the likelihood of developing lung cancer continually … …American Journal of Biochemistry and Biotechnology, Vol. 19, Issue 1 · 20 Feb 2023 · 5,450 accessesView PDFCite