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281 articles for “Inhibitor”
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Research ArticleOpen accessEvery word in the titleMetabolic Abnormalities Associated with the Use of Protease Inhibitors and Non-nucleoside Reverse Transcriptase InhibitorsMadhu N. Rao, Grace A. Lee, Carl GrunfeldThe use of protease inhibitors and non-nucleoside reverse transcriptase inhibitors for the treatment of HIV infection and AIDS has been associated with multiple abnormalities in glucose and lipid metabolism. Specifically, these abnormalities include insulin resistance, increased triglycerides and increased LDL cholesterol levels. The metabolic disturbances are due to a combination of factors, including the direct effect of medications, restoration to … …American Journal of Infectious Diseases, Vol. 2, Issue 3 · 30 Sep 2006 · 6,936 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleOptimization of Ultrasonic-Assisted Total Flavonoids Extraction from Flower of Albizia Julibrissin Durazz. by Response Surface Methodology for Characterization of Chemical Profile and Evaluation of Antioxidant and Tyrosinase Inhibitory ActivitiesYijie Cheng, Yuwen Zhang, Hanzhang Sun et al.To investigate the flavonoids in flower of Albizia julibrissin (‘He Huan Hua’ in Chinese), the ultrasonic-assisted extraction of total flavonoids from ‘He Huan Hua’ was optimized by response surface methodology and the chemical profile was characterized by HPLC- QTOF-MS/MS. What’s more, the antioxidant and tyrosinase inhibitory activities of ‘He Huan Hua’ were also evaluated in this study. The extraction time, … …American Journal of Biochemistry and Biotechnology, Vol. 18, Issue 1 · 14 Mar 2022 · 6,733 accessesView PDFCite
Review ArticleOpen accessEvery word in the titleProton Pump Inhibitors in Veterinary MedicineOguzhan Yavuz, Handan Hilal ArslanInhibition of gastric acid secretion is necessary to treat many gastrointestinal diseases. Proton Pump Inhibitors (PPIs) are very effective drugs, used for gastric acid inhibition and therapy of important erosive and non-erosive gastrointestinal disorders in animals as well as humans. In this review, general properties of PPIs, their mode of action, pharmacokinetics, efficacy, adverse effects, drug interactions and clinical and … …American Journal of Animal and Veterinary Sciences, Vol. 12, Issue 3 · 5 Jul 2017 · 14,265 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleEffect of Inhibitory Substances on Microbiospora Isolated from Soil under Cultivation of Curcuma Longa L.A. P. Kamble, Prakash Thorat, S. W. KulkarniProblem statement: Soil Pollution is major problem because different types of pesticides are used to control plant pest. The residual component of pesticide diffuses into the soil. It is necessary to check whether actinomycetes degrade these components and control the soil pollution. Approach: In Ayurved system of medicine the rhizome portion of Curcuma longa L. was used as an anti-inflammatory … …OnLine Journal of Biological Sciences, Vol. 12, Issue 1 · 16 Mar 2012 · 7,819 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleThe Effects of Protease Inhibitors on Metabolic Complications and Lipodystrophy in Human Immunodeficiency Virus-Infected PatientsMohd Khaza, K. Laxmi Prasad, M. EstariProblem statement: Highly Active Antiretroviral Therapy (HAART)-associated metabolic complications include lipoatrophy (loss of Subcutaneous Adipose Tissue (SAT) and insulin resistance. The risk of Diabetes Mellitus (DM) in Human Immunodeficiency Virus (HIV)-infected patients receiving Highly Active Antiretroviral Therapy (HAART) especially protease inhibitors has not been well defined. Approach: We conducted an analysis in the Hospital of Rajeev Gandhi Institute of Medical … …Current Research in Medicine, Vol. 1, Issue 2 · 31 Oct 2010 · 6,934 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleThe Lipid-Lowering Efficacy of Switching Within Non-Nucleoside Reverse Transcriptase Inhibitors in HIV-Infected PatientsA.M. Bain, K.D. Payne, A.P. Rahman et al.The objective of present research is to evaluate the lipid lowering efficacy and safety of switching within non-nucleoside reverse transcriptase inhibitors (NNRTI) in HIV-infected patients. This is a multicenter, retrospective study utilizing a comprehensive electronic patient registry to identify all adult HIV-infected patients seen from October 1, 1998 through October 1, 2006, who substituted efavirenz for nevirapine (EFV→NVP) or vice-versa … …American Journal of Infectious Diseases, Vol. 4, Issue 2 · 30 Jun 2008 · 6,743 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleStudy of Ageratum conyzoides L. (Asteraceae) Phytochemical Composition as Quorum-sensing Inhibitors to Combat Antibiotic-resistant Bacterial InfectionsEli Compaoré, Lassané Ouedraogo, Ablassé Rouamba et al.The rise of antibiotic-resistant bacterial infections has intensified the search for plant-derived quorum-sensing (QS) inhibitors as alternative therapeutic strategies. Ageratum conyzoides L. has a long history of traditional use as an antimicrobial agent against multidrug-resistant pathogens, yet the phytochemical basis of its QS-inhibitory activity remains incompletely characterized. This study aimed to investigate the phytochemical composition of A. conyzoides and evaluate … …OnLine Journal of Biological Sciences, Vol. 26, Issue 1 · 3 Apr 2026 · 1,772 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleMolecular Dynamics Simulation of DENV RNA-Dependent RNA-Polymerase with Potential Inhibitor of Disulfide Cyclic PeptideUsman Sumo Friend Tambunan, Raima Syahidah Noors, Arli Aditya Parikesit et al.Problem statement: Our researches have proposed two ligands of disulfide cyclic polypeptide, which are CDEEC and CDGSC as potential inhibitor of DENV RNA-dependent RNApolymerase by molecular docking. Approach: Methodological approach was conducted to determine the best ligand to act as inhibitor. Molecular docking simulation was conducted without a solvent in which enzyme was made rigid and ligand was left free … …OnLine Journal of Biological Sciences, Vol. 11, Issue 2 · 30 Sep 2011 · 8,441 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleAnalysis of Resistance to Human Immunodeficiency Virus Protease Inhibitors Using Molecular Mechanics and Machine Learning StrategiesA. Harishchander, D. Alex Anand, Sanjib SenapatiProblem statement: Drug resistance is the most important factor, which influences the failure of current HIV therapies. So, the ability to predict the drug resistance of HIV-1 protease mutants will be useful in developing more effective and longer lasting treatment regimens. Approach: Drug resistance of HIV-1 protease is predicted with two current protease inhibitors (Indinavir and Saquinavir). The problem was … …Current Research in Medicine, Vol. 1, Issue 2 · 31 Oct 2010 · 7,204 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleCardiac Depression Produced by L-Arginine and Phosphodiestrase Inhibitor on Isolated Mammalian Rabbit Heart: Function of Cyclic Guanosine Monophosphate (cGMP)Hussein F. Sakr, Fahaid Al-Hashem, Mahmoud Al-Khateeb et al.Problem statement: Cyclic guanosine 3',5'-monophosphate cGMP is one the important second messengers that determines the cardiomyocyte activity and its role in healthy and diseased cardiac muscle is still controversial. We are reporting the effect of adding L-arginine, the NO donor that stimulates cGMP production and Sildenafil citrate (phosphodiestrase inhibitor) that inhibits cGMP hydrolyis on isolated rabbit’s heart to answer: Is … …American Journal of Pharmacology and Toxicology, Vol. 5, Issue 2 · 30 Jun 2010 · 8,182 accessesView PDFCite